Abstract: A system for auto-anastomosing a region of the body using magnetic members that may be individually delivered to different locations in the body. The magnetic members have a polar alignment that generates an attractive force to compress tissue in the region between them. The tissue in the region necroses as a result of the compressive force such that tissue surrounding the necrosed tissue heals together to form an anastomosis. A cutting member may be coupled to either the first or second magnetic member to create a temporary opening in the tissue.

Abstract: The invention provides methods for treating neurological disorders, which involve administering therapeutic agents to the thalamus by convection enhanced delivery.

Abstract: Methods and apparatus for incrementally manipulating an internal body member of a patient are disclosed. The apparatus has a magnetic implant adapted to be received on a location of the body member, a platform external to the patient, and a magnetic member coupled to the platform, wherein the magnetic member generates a magnetic force between the implant and the platform to incrementally manipulate the body member. The implant and external magnetic member are preferably rare earth magnets or an array of rare earth magnets, and are configured to generate an attractive or repulsive force between the implant and the platform to reposition, reorient, deform, or lengthen the body member.

Abstract: Methods of preparing monoclonal antibodies that differentially bind to a single conformer of a protein of interest are described. Passive immunization using these antibodies as well as use of conformer-specific antibodies as diagnostic reagents for the purpose of stratification of patient populations with regards to disease outcome, drug efficacy or drug sensitivity is also disclosed as well as active immunization with the protein conformer. In the screening techniques, detection can be for example by tissue immunostaining, western blotting or solution IP. A specific mab termed 7VC which shows conformation specificity to CtmPrP, a prion protein conformer that triggers neurodegeneration under specific assay conditions of pH and copper concentration, is described. A second specific antibody termed 19B10 shows conformation specificity for NtmPrP, a prion protein conformer that downregulates total PrP expression and effects cell differentiation.

Abstract: A system and method are provided for developing a database of body surface ECG P-wave maps for classification and localization of left-sided atrial arrhythmias. The system and method include generating and receiving P-wave data in a subject by left atrial pacing or receiving P-wave data in a subject during spontaneously occurring or induced left atrial arrhythmias; computing (e.g. potential or integral) maps of the P-wave data; classifying the maps specific to a left atrial ectopic origin; verifying the classification procedure; averaging the classified maps into mean maps; and storing and accessing the mean maps in the database. The mean maps of the P-wave data in the database can be used to automatically classify and localize P-wave data from a patient obtained during a left atrial arrhythmia such as atrial tachycardia, focal atrial fibrillation, or orthodromic atrioventricular reentrant tachycardia.

Abstract: The invention described herein provides computer-implemented methods and systems for alleviating an abnormal behavior, such as a behavior associated with a fear, abnormal activity, or obsession. It has been found that behaviorally abnormal self-sustaining behaviors may be unlearned or diminished through directed forms of computer-implemented interaction. The computer-implemented interaction is generally directed to reduce the neurological representations of inputs and actions associated with the abnormal behavior. The interaction will typically comprise strategically and repeatedly presenting computer-implemented stimuli including context related to the abnormal behavior. The computer-implemented stimuli are then repeatedly presented and altered over time in a manner that alleviates the abnormal behavior. For example, the content of the computer-implemented stimuli may change to gradually vary in their ability to trigger an episode in the person.