Publication number: 20230285405
Abstract: In aspects, the invention provides a method of treating or preventing a nidovirus or picornavirus infection in a subject, the method comprising administering to a subject in need thereof an effective amount of an active agent of butamben, butylparaben, conivaptan, amphotericin B, pentoxyverine, lapatinib, vilazodone, imatinib (STI571), benztropine, raloxifene, solifenacin, retapamulin, bafetinib (INNO-406), imipramine, trimipramine, tolterodine, clomipramine, velpatasvir, cediranib (AZD2171), azelastine, desloratadine, nortriptyline, propafenone, mebeverine, elbasvir, cepharanthine, flupenthixol dihydrochloride, or a pharmaceutically acceptable salt thereof.
Type:
Application
Filed:
August 6, 2021
Publication date:
September 14, 2023
Applicant:
The University of Chicago
Inventors:
Savas Tay, Glenn Randall, Nir Drayman, Siquan Chen
Patent number: 11753408
Abstract: Disclosed are compounds of formula (I) and formula (II): wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.
Type:
Grant
Filed:
April 22, 2021
Date of Patent:
September 12, 2023
Assignees:
The United States of America, as represented by the Secretary, Department of Health and Human Services, Loyola University of Chicago
Inventors:
Wenwei Huang, Hao Li, Wei Sun, Xiuli Huang, Paresma R. Patel, Hangmao Sun, Wei Zheng, Xiao Lu, Philip E. Sanderson, Myunghoon Kim, Meghan J. Orr, Gregory J. Tawa, Kim C. Williamson