Patents Assigned to University of Copenhagen
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Publication number: 20240148798Abstract: Described is a method for the treatment or prevention of GI tract dysbiosis in a subject, said method including administering an effective amount of a non-viable Methylococcus capsulatus or a lysate of Methylococcus capsulatus to said subject. The invention further provides a method for the treatment or prevention of a disease or condition selected from small intestine bacterial overgrowth (SIBO), small intestine fungal overgrowth syndrome (SIFO), GI tract cancers, breast cancer, neurological disorders, malnutrition, chronic fatigue syndrome, autism, cardiovascular diseases and GI tract infections in a subject with GI tract dysbiosis, said method including administering an effective amount of a non-viable Methylococcus capsulatus or a lysate of Methylococcus capsulatus to said subject. A non-viable Methylococcus capsulatus or a lysate of Methylococcus capsulatus for use in said methods is further provided.Type: ApplicationFiled: January 16, 2024Publication date: May 9, 2024Applicants: Norges Miljo-Og BIovitenskapelige Universitet (NMBU), Sykehuset Ostfold HF, University of CopenhagenInventors: Tor Lea, Charlotte Kleiveland, Karsten Kristiansen, Benjamin Anderschou Holbech Jensen, Jacob Bak Holm, Ida Sogaard Larsen, Morten Jacobsen
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Patent number: 11958032Abstract: The invention regards a composite for environmental remediation, comprising: —one or more green rust compound(s) or green rust precursor(s), and—one or more biochar(s).Type: GrantFiled: December 4, 2018Date of Patent: April 16, 2024Assignee: University of CopenhagenInventors: Jing Ai, Weizhao Yin, Hans Christian Bruun Hansen
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Patent number: 11950516Abstract: The present disclosure relates to a method for manufacturing of specially designed substrates for growth of nanostructures and patterned growth on said nanostructures. The present disclosure further relates to nanostructures, in particular hybrid semiconductor nanostructures with patterned growth of superconducting material for use in quantum devices. The presently disclosed method can be utilized for in-situ manufacturing of quantum devices that have not been contaminated by ex-situ processes.Type: GrantFiled: March 25, 2019Date of Patent: April 2, 2024Assignee: University of CopenhagenInventors: Thomas Sand Jespersen, Jesper Nygård, Damon Carrad, Martin Bjergfelt
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Patent number: 11911418Abstract: Described is a method for the treatment or prevention of GI tract dysbiosis in a subject, said method including administering an effective amount of a non-viable Methylococcus capsulatus or a lysate of Methylococcus capsulatus to said subject. The invention further provides a method for the treatment or prevention of a disease or condition selected from small intestine bacterial overgrowth (SIBO), small intestine fungal overgrowth syndrome (SIFO), GI tract cancers, breast cancer, neurological disorders, malnutrition, chronic fatigue syndrome, autism, cardiovascular diseases and GI tract infections in a subject with GI tract dysbiosis, said method including administering an effective amount of a non-viable Methylococcus capsulatus or a lysate of Methylococcus capsulatus to said subject. A non-viable Methylococcus capsulatus or a lysate of Methylococcus capsulatus for use in said methods is further provided.Type: GrantFiled: April 12, 2022Date of Patent: February 27, 2024Assignees: Norges Miljo-Og Blovitenskapelige Universitet (NMBU), Sykehuset Ostfold HF, University of CopenhagenInventors: Tor Lea, Charlotte Kleiveland, Karsten Kristiansen, Benjamin Anderschou Holbech Jensen, Jacob Bak Holm, Ida Sogaard Larsen, Morten Jacobsen
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Publication number: 20240052000Abstract: The present invention relates to mutated bacterial host cells, said host cells producing a polypeptide of interest and having at least one disrupted flagellum gene, and to nucleic acid constructs and vectors encoding at least one flagellum polypeptide with reduced or eliminated activity as well as to methods of producing one or more polypeptide of interest in said host cells.Type: ApplicationFiled: December 15, 2021Publication date: February 15, 2024Applicants: Novozymes A/S, University of CopenhagenInventors: Thomas Krogh Kallehauge, Annaleigh Ohrt Fehler, Adrian Sven Geissler, Jan Gorodkin, Jeppe Vinther
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Patent number: 11819552Abstract: The present invention relates to conjugates targeting uPARAP, in particular antibody-drug conjugates (ADCs) comprising monoclonal antibodies directed against the N-terminal region of uPARAP, and their use in delivery of active agents to cells and tissues expressing uPARAP. The invention further relates to the use of said ADCs in the treatment of diseases involving uPARAP expressing cells, such as cancer.Type: GrantFiled: February 3, 2021Date of Patent: November 21, 2023Assignees: Rigshospitalet, University of CopenhagenInventors: Christoffer Nielsen, Niels Behrendt, Lars Henning Engelholm
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Patent number: 11813327Abstract: The present invention relates to a vaccine comprising a nucleic acid construct such as a DNA construct especially a nucleic acid construct comprising sequences encoding invariant chain operatively linked to antigenic protein or peptide encoding sequences. The present vaccine stimulates an enhanced immune response.Type: GrantFiled: October 18, 2021Date of Patent: November 14, 2023Assignee: UNIVERSITY OF COPENHAGENInventors: Peter Johannes Holst, Cyrielle Elyette Fougeroux
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Patent number: 11793752Abstract: An aqueous gel composition comprising a) water, at least one polysaccharide and at least one high molecular weight polyethylene oxide, wherein the water content is at least 90% by weight of the composition, and b) a local anaesthetic agent or an analgesic agent, for use as a local anaesthetic or analgesic. The aqueous gel shows transparency, lubricity, stringiness, elongation, extensiveness, and cohesiveness while being devoid of taste and smell and non-tacky or non-sticky.Type: GrantFiled: January 13, 2021Date of Patent: October 24, 2023Assignee: University of CopenhagenInventors: Daniel Bar-Shalom, Jette Jacobsen, Kasper Dalby, Anne Marie Lynge Pedersen, Peter Vilmann
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Publication number: 20230277600Abstract: The present application relates to alleviating adverse effects of oligodendrocyte loss, astrocyte loss, or white matter loss, including age-related oligodendrocyte loss, age-related astrocyte loss, or age-related white matter loss, in the brain of a subject. The present application also relates to rejuvenating a glial progenitor cell or a progeny thereof, or to enhancing the development potential of a glial progenitor cell or a progeny thereof.Type: ApplicationFiled: October 19, 2022Publication date: September 7, 2023Applicants: University of Rochester, University of CopenhagenInventors: Steven A. Goldman, Ricardo da Costa Barbedo Vieira
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Publication number: 20230270140Abstract: A betalain pigment composition from red beet plants including pre-harvest foliar spraying of an ethylene-generating compound and the use of the obtained betalain pigment composition for coloring of an edible productType: ApplicationFiled: May 10, 2023Publication date: August 31, 2023Applicants: CHR. HANSEN NATURAL COLORS A/S, UNIVERSITY OF COPENHAGENInventors: Gregorio Barba ESPIN, Henrik Vlk LUETKEN, Bjarne JOERNSGAARD, Renate Petra Brigitte MUELLER, Tsaneta DZHANFEZOVA, Stephan GLIED, Bjoern MADSEN
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Patent number: 11725037Abstract: Provided herewith are peptide dual agonists of at least the GIPR (glucose-dependent insulinotropic polypeptide receptor) and the GLP2R (glucagon-like peptide-2 receptor), and their use for treatment of bone disorders such as osteoporosis.Type: GrantFiled: August 31, 2020Date of Patent: August 15, 2023Assignee: University of CopenhagenInventors: Bolette Hartmann, Maria Buur Nordskov Gabe, Lærke Smidt Gasbjerg, Mette Marie Rosenkilde, Jens Juul Holst
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Publication number: 20230241118Abstract: The present application relates to alleviating adverse effects of oligodendrocyte loss, astrocyte loss, or white matter loss, including age-related oligodendrocyte loss, age-related astrocyte loss, or age-related white matter loss, in the brain of a subject. The present application also relates to rejuvenating a glial progenitor cell or a progeny thereof, or to enhancing the development potential of a glial progenitor cell or a progeny thereof.Type: ApplicationFiled: October 19, 2022Publication date: August 3, 2023Applicants: University of Rochester, University of CopenhagenInventors: Steven A. Goldman, Ricardo da Costa Barbedo Vieira
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Patent number: 11708569Abstract: The present invention relates to lysosomal enzymes modified by use of cell based methods, a compositions comprising a modified lysosomal enzyme, as well as methods for producing a modified lysosomal enzyme and therapeutic use of such modified lysosomal enzyme. In particular, the present disclosure relates to a modified lysosomal enzyme which has low Man6P and low exposed Mannose and high sialic acid content of alpha2,3 type enabling long circulation time and improved uptake into difficult-to-reach organs like heart, kidney and brain.Type: GrantFiled: August 29, 2019Date of Patent: July 25, 2023Assignees: University of Copenhagen, GLYCODISPLAY APSInventors: Claus Kristensen, Weihua Tian, Henrik Clausen, Zhang Yang, Sergey Vakhrushev
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Publication number: 20230211307Abstract: The present disclosure provides methods, devices, systems and kits for producing polymeric microbeads, including lanthanide-encoded microbeads. Among others, the present disclosure provides methods, systems and kits for producing functionalized microbeads that include on their surfaces amphipathic moieties with free reactive groups that remain free and can be used for covalently coupling molecules or moieties of inters to the microbeads.Type: ApplicationFiled: June 10, 2021Publication date: July 6, 2023Applicants: Chan Zuckerberg Biohub, Inc., The Board of Trustees of the Leland Stanford Junior University, University of CopenhagenInventors: Yinnian Feng, Adam K. White, Jamin B. Hein, Polly M. Fordyce
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Patent number: 11690389Abstract: A method for obtaining a betalain pigment composition from red beet plants comprising pre-harvest foliar spraying of an ethylene-generating compound and the use of the obtained betalain pigment composition for coloring of an edible product.Type: GrantFiled: September 21, 2018Date of Patent: July 4, 2023Assignees: UNIVERSITY OF COPENHAGEN, OTERRA A/SInventors: Gregorio Barba Espin, Henrik Vik Luetken, Bjarne Joernsgaard, Renate Petra Brigitte Mueller, Tsaneta Dzhanfezova, Stephan Glied, Bjoern Madsen
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Patent number: 11680250Abstract: The present disclosure relates to a light-driven system which is able to chemically modify an organic substrate with high efficiency and in a cost-effective manner. Also provided are methods for chemically modifying an organic substrate using the present systems and methods for manufacturing such systems.Type: GrantFiled: July 14, 2016Date of Patent: June 20, 2023Assignee: University of CopenhagenInventors: Claus Felby, David Cannella, Klaus Benedikt Möllers
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Patent number: 11613736Abstract: The present invention relates to a method for isolating bona fide pancreatic progenitor cells and to cell populations enriched for bona fide pancreatic progenitor cells.Type: GrantFiled: October 15, 2019Date of Patent: March 28, 2023Assignee: University of CopenhagenInventors: Jacqueline Ameri, Henrik Semb
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Patent number: 11572399Abstract: Disclosed are glucose-dependent insulinotropic peptide (GIP)-derived peptide analogues GIPS-30 and GIP3-30 which are antagonists of the GIP receptor and comprises at least one fatty acid molecule to increase half-life while maintaining antagonistic properties.Type: GrantFiled: May 31, 2018Date of Patent: February 7, 2023Assignee: UNIVERSITY OF COPENHAGENInventors: Mette Marie Rosenkilde, Jens Juul Holst, Lærke Smidt Gasbjerg, Alexander Hovard Sparre-Ulrich, Maria Buur Nordskov Gabe
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Patent number: 11554261Abstract: The present disclosure relates to a system for generating a predefined electrical signal in an MR scanner for use in electrical stimulation of a subject during MRI or functional MRI of said subject, wherein said MR scanner is located inside a shielded MRI room. The system comprises a control unit to be located outside the MRI room for generating an electrical signal and an electrical to optical converter to be located outside the MRI room for converting said electrical signal to a corresponding optical signal. An optical transmitting element, such as an optical fiber, is used for transmitting the optical signal into the MRI room, and an optical to electrical converter is used for converting the optical signal to said predefined electrical signal for electrical stimulation of the subject during magnetic resonance imaging. The optical to electrical converter is configured for being located inside the MRI room and for operation during magnetic resonance imaging.Type: GrantFiled: October 5, 2018Date of Patent: January 17, 2023Assignees: Roskilde/Køge Hospital, Rigshospitalet, University Of CopenhagenInventors: Anders Ohlhues Baandrup, Louise Møller Jørgensen, Carsten Thomsen
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Patent number: 11556045Abstract: A device for generating individual photons with energy E includes quantum emitters, having at least one determined transition with the energy E from an energy level N* to a lower energy level N1. The emitters are near a propagation path running from first to second regions. The device also includes at least one light source to output light, for propagation along the path. The light has the energy E for resonant excitation of the energy level N*. The emitters are arranged so that optionally exactly Z emitters are illuminated, forming an optical thickness ?>0 for the light along the path. The number Z lies in a range of Z0±10% and Z0 is a number at which a maximum destructive interference in the second region occurs between a two-photon component of the light scattered on the ZO emitters and a two-photon component of the non-scattered light.Type: GrantFiled: September 20, 2019Date of Patent: January 17, 2023Assignees: Humboldt-Universitaet zu Berlin, University of CopenhagenInventors: Philipp Schneeweiss, Juergen Volz, Arno Rauschenbeutel, Sahand Mahmoodian, Anders Søndberg Sørensen