Abstract: The present invention relates to a method for improving the production of an influenza virus, and in particular influenza vaccine seeds, or a vaccine directed against an influenza virus, characterized in that the production is carried out in the presence of an inhibitor of the interaction between the Mdm2 protein and the p53 protein.

Abstract: The invention provides compounds according to formula (I): (wherein X, Y, Z1 R1, R2, R3, Ar and Ar? are as defined herein), and physiologically acceptable salts, solvates, esters or amides thereof, pharmaceutical compositions comprising these compounds and the compounds for use in medicine, for example for the treatment or prophylaxis of diseases involving cell proliferation, such as cancer, and for the treatment or prophylaxis of other diseases.

Abstract: The present invention concerns compounds derived from the anaesthetic propofol that are useful as analgesics and methods of using the same. The compounds act as co-activators of strychnine-sensitive glycine receptors and may have greater activity at those glycine receptors than at GABAA.

Abstract: A STED microscope for producing a 3D image. The microscope has an excitation laser source for providing an excitation laser beam and a depletion laser source for providing stimulated emission depletion laser beam. The excitation beam is capable of exciting fluorescent markers in a sample placed in the sample region and the depletion beam is capable of inducing stimulated emission in the fluorescent marker in the sample in a region around the excitation beam to restrict the size of the region within which the fluorescent markers are excited and wherein the depletion laser source goes through an optical element which creates a cone refractive pattern which induces stimulated emission in the fluorescent marker in the sample. The shape of the light hollow of the cone refractive pattern varies at different distances from the source. This depth profile can be used to distinguish between positions at varying depths within a sample to create a 3D image.

Abstract: The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.

Abstract: The present invention relates to agents capable of binding sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) and their use in the treatment of cell proliferation and differentiation disorders. Furthermore, the present invention provides associated pharmaceutical formulations and methods.

Abstract: Disclosed is a device adapted to measure intraocular pressure comprising: a corneal contact lens having a pressure sensor mounted in a recess or cavity in the contact lens, and wherein the contact lens has a back surface which is formed so as to protrude in a desired portion beyond the profile of the adjacent part of the lens and thus to press against the cornea, which protruding portion experiences a reactive deformation which is detected directly or indirectly by the pressure sensor.

Abstract: The present invention relates to agents capable of binding sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) and their use in the treatment of cell proliferation and differentiation disorders. Furthermore, the present invention provides associated pharmaceutical formulations and methods.

Abstract: A system for arranging searchable items, such as digital images or multimedia icons for presentation on a graphical user interface. The system has an optimizer module which minimizes a cost function for arranging items in a layout space and is applied to one or more predetermined characteristics of the items. The optimizer module also creates a mixture distribution by considering each item as having a spatial distribution in the layout space and controls the entropy of the mixture distribution in order to maximize the extent to which each item occupies a separate position in the layout space. A Renderer module then renders the layouts to generate a display.

Abstract: Non-human animals which overexpress PPARd or which express transgenic PPARd are useful as models for inflammatory skin conditions such as psoriasis. Test substances can be screened to assess their suitability for the treatment of inflammatory skin conditions such as psoriasis. Methyl 3-({[2-(methoxy)-4-phenyl]amino}sulfonyl)-2-thiophenecarboxylate can be administered topically for the prevention or treatment of psoriasis.

Abstract: A method and apparatus for metalizing a substrate by heating and applying a voltage across an ion exchange substrate to embed metallic ions from a metallic layer within the ion exchange substrate by a process of ion exchange. The resultant as-diffused substrate has metallic ions are distributed substantially homogeneously across the substrate. This may be metalized by applying a pulsed laser beam to a surface of the as-diffused substrate at or near a concentration of metallic ions such that the energy of the laser causes the conversion of the metallic ions in the as-diffused substrate into metal atoms at or near the point at which the laser pulse is incident upon the as-diffused substrate thereby creating a metalized substrate with a surface pattern defined by the movement of the laser beam across the surface of the as-diffused substrate.

Abstract: The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions involving sirtuin function.

Abstract: A surgical tissue anchor comprising a plurality of jaws suitable for clamping onto tissue, clamp component(s) operable to bias the jaws in a closed position and attachment structure operable for attachment of the anchor to one or more tethers for retracting the clamped tissue. The one or more tethers are guided to the desired region using a surgical guide.

Abstract: The present invention provides methods for enhancing the synthesis of isotope labelled native proteins in specific biological pathways for the purpose of protein quantification and qualification. The invention provides reference samples for use in various mass-spectrometry-based methods of protein analysis.

Abstract: The invention relates to morpholino-derivatives according to Formula (I) or stereoisomers or pharmaceutically acceptable salts or solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, m and n are as defined in the specification. The compounds are antagonists, reverse agonists or agonists of G-protein coupled receptors, such as dopamine D4 and 5HT1a. The inventions also relates to pharmaceutical compositions comprising the compounds and methods involving the compounds and compositions. The compounds and compositions of the invention may in particular be used in the treatment of diseases and disorders, such as neurological and neurodegenerative diseases; or as lead compounds for the design and selection of further therapeutic compounds.

Abstract: The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.

Abstract: The present invention relates to a multi-functional protease inhibitor, which may be conjugated to various molecules. The present invention also relates to uses of the protease inhibitor and conjugates thereof.

Abstract: The present invention relates to a biomarker for Parkinson's disease. The biomarker and products associated with the biomarker may be used to assist diagnosis or to assess onset and/or development of Parkinson's disease. The invention also relates to use of the biomarker in clinical screening, assessment of prognosis, evaluation of drug treatments, drug screening or drug development in the field of Parkinson's disease and Parkinson's disease related disorders.

Abstract: The present invention relates to the identification of loss-of-function mutations in the filaggrin gene and their use in diagnosing ichthyosis vulgaris and/or susceptibility to other diseases including atopic dermatitis (eczema), asthma, psoriasis and allergies (including food allergy).

Abstract: The described invention relates to compounds (I) which modulate cell migration, and find use in, for example, wound healing, cancer progression and angiogenesis. All definitions as in claim 1.