Abstract: The invention relates to methods of increasing photosynthetic capacity in plants by modulating the cryptochrome 1 (CRY1)-directed signalling pathway. In certain embodiments, the invention relates to removing constraints on maximal photosynthetic capacity by reducing or abolishing SPA gene expression and/or activity. The invention further relates to plants having increased photosynthetic capacity, identifying plants with increased photosynthetic capacity and methods of producing food or feed products.

Abstract: Certain aspects of the present invention relate to modified hemoglobin proteins comprising at least one modification (e.g., at the thiol group of an exogenous amino acid residue) for homogenous conjugation of one or more polymeric moieties e.g. polyethylene glycol or derivatives thereof. Also included herein are methods of using such modified proteins and compositions comprising such proteins, e.g. in therapy.

Abstract: Aspects of the present disclosure relate to genetically altered plants with enhanced biomass including genetic alterations that stimulate RubP regeneration and electron transport. In particular, the present disclosure relates to genetically altered plants with enhanced biomass through overexpression of CB proteins (e.g., FBPase/SBPase or SBPase), and overexpression of photosynthetic electron transport proteins (e.g., cytochrome c6 and Rieske FeS).

Abstract: A visual stress assessment device is provided comprising a plurality of coloured light sources, each adapted to produce light of a predetermined hue, and a white light source. The white light source and the coloured light sources each comprise a plurality of light emitting diodes. A chamber is provided having an interior comprising a viewable region configured to provide a sample for inducing visual stress, wherein said viewable region is arranged to be illuminated by the white light source and the coloured light sources. A controller is configured to selectively operate the white light source and coloured light sources such that only one or both of a first of the coloured light sources and a second of the coloured light sources are operated simultaneously with the white light source, whereby their respective emitted light is observable in the viewable region by a user at a predetermined hue and saturation.

Abstract: The present invention relates to a method for diagnosing, evaluating the prognosis of a cancer patient and evaluating the aggressiveness of a cancer. The methods comprise detecting the phosphorylation status of a Scribble protein, a fragment or variant thereof, wherein the phosphorylation status is indicative of cancer, prognosis and the aggressiveness of a cancer. In one embodiment the cancer is breast cancer.

Abstract: A method and apparatus are disclosed for determining behaviour of a plurality of candidate objects in a multi-candidate object scene. The method comprises the steps of frame-by-frame, extracting behaviour features from video data associated with a scene, providing the behaviour features to an input of a recognition module comprising an interval Type 2 Fuzzy Logic (IT2FLS) based recognition model and classifying candidate object behaviour for a plurality of candidate objects in a current frame by selecting a candidate behaviour model having a highest output degree for each candidate object.

Abstract: The present invention relates to a method for diagnosing, evaluating the prognosis of a cancer patient and evaluating the aggressiveness of a cancer. The methods comprise detecting the phosphorylation status of a Scribble protein, a fragment or variant thereof, wherein the phosphorylation status is indicative of cancer, prognosis and the aggressiveness of a cancer. In one embodiment the cancer is breast cancer.

Abstract: The present invention relates to a method for diagnosing, evaluating the prognosis of a cancer patient and evaluating the aggressiveness of a cancer. The methods comprise detecting the phosphorylation status of a Scribble protein, a fragment or variant thereof, wherein the phosphorylation status is indicative of cancer, prognosis and the aggressiveness of a cancer. In one embodiment the cancer is breast cancer.

Abstract: The present invention relates to a method for diagnosing, evaluating the prognosis of a cancer patient and evaluating the aggressiveness of a cancer. The methods comprise detecting the phosphorylation status of a Scribble protein, a fragment or variant thereof, wherein the phosphorylation status is indicative of cancer, prognosis and the aggressiveness of a cancer. In one embodiment the cancer is breast cancer.

Abstract: The present invention relates to a modified porphyrin-based oxygen-carrying protein, such as haemoglobin, which has been found, in its unmodified state to have a low affinity site of electron transfer and a high affinity electron transfer between a reductant and ferryl haem iron via one or more protein amino acids. The invention provides such proteins that comprise a modification to enhance this pathway.

Abstract: An integrated circuit assembly having monitoring circuitry for observing the internal signals of the system so that its properties are captured. The system properties are manipulated so that they can be used as a pseudo random number and or as the basis number for an encryption key. The monitoring circuitry having: manipulation circuitry to transform monitored data and combine it with previously manipulated values; and registers to store previously manipulated values; and counters to count events; and condition detection circuitry for detecting when a signal is at a specific value or range of values. Optionally the monitoring circuitry which has the functionality for capturing system properties may be combined with other monitoring circuitry, which has the functionality required by a debug support circuit. The monitoring circuitry avoids replication of resources by sharing parts of specific monitoring circuits like counters.

Abstract: A detector for electromagnetic radiation in the range 80 GHz to 4 THz comprises a laser light source (115) an optical modulator (13) arranged to modulate light from the laser light source (11) and a filter system (17) for selecting a defined range of frequencies of the modulated light. The optical modulator is an electroabsorption modulator (13) with an antenna (15) which is sensitive to electromagnetic radiation in the range 80 GHz to 4 THz. The signal received by the antenna (15) modulates the electric field across the electroabsorption modulator (13), whereby to modulate the light from the laser light source (11).

Abstract: A process provides for an electrochemical deposition by forming a solution of ions of at least one metal (A) capable of forming a hydrogen bronze and ions of at least one metal (B) from Group VIII of the periodic table, and causing electrochemical deposition from the solution onto a cathodic substrate.

Abstract: A headphone assembly for an active noise cancellation system has a rigid moulded plastics shell having a rigid baffle dividing the shell interior into a front volume and a closed rear volume, both of which may be filled with an acoustic foam. The baffle has a central opening in which is mounted a headphone transducer, and a seal cushion is disposed around the mouth of the shell, to effect an air-tight seal against the user's head. The headphone transducer has two effective sound radiating surfaces of different sizes, and may be constructed as a form of orthodynamic drive unit. In the latter case, the orthodynamic drive unit diaphragm may have two separate coils of different radial extents.

Abstract: In a non-destructive method for the detection of surface cracks in metals, an eddy current is induced in the surface region of a workpiece under test, at a frequency sufficiently high to generate an alternating magnetic field solely in the skin region of the workpiece. That alternating surface magnetic field is interrogated by means of a relatively small electro-magnetic induction sensor, having regard to the overall area of the induced magnetic field. The sensor provides a voltage output which is analysed, preferably in real time, to yield an indication sensor. Also described is a probe for performing such a method.

Abstract: A method of and an apparatus for rapidly determining the polarization state of an incoming beam of light, such as from a fibre optic. The incoming beam is passed through a beam expander and then four separate portions of that beam are passed simultaneously through four Stokes filters respectively, arranged in a common plane. The four filtered beam portions are directed by respective lenses on to four detectors providing electrical signals indicative of the intensity of the respective filtered beams. From these four signals, the Stokes parameters may be deduced. The method allows very rapid assessments of the polarization state of an incoming beam to be achieved, and a bandwidth of several tens of KHz is attainable.