Abstract: Systems and devices for detecting and characterizing stratified fluid and/or aerosol particles and droplets, and methods of use thereof to, for example, diagnose and prognose respiratory diseases and disorders are provided. The systems typically include optoelectronic sensors for detecting foreign particles like bacteria and pollutants in the air (i.e., the aerosol) based on light scattering. Information collected in this way can be used to, for example, detect or identify respiratory maladies and determine the effectiveness of methods of treatment thereof.

Abstract: Monoclonal antibodies and antigen binding fragments that specifically bind pneumococcal proteins, specifically pneumococcal histidine triad protein (PhtD) and pneumococcal surface protein A (PspA), are provided. Also disclosed are nucleic acid molecules encoding the antibody, antigen binding fragment, a VH or VL of the antibody, or a multipiece antibody including the VH and/or VL, vectors including these nucleic acid molecules, and host cells transfected with these vectors. Methods of inhibiting, treating, and detecting a Streptococcus pneumoniae infection are also provided.

Abstract: In an embodiment, the invention is directed to prodrug compounds of L-BHDU according to the chemical structure I: Where R1 is a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group; R2 is H, a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group; R1a is independently a C6-C30 alkyl group, often a C12-C22 alkyl group, often a C14-C20 alkyl group or a C16-C18 alkyl group, often a C16 or C18 alkyl group; R2a is independently a C1-C12 alkyl group, often a C2-C6 alkyl group, a C3-C4 alkyl group, an isopropyl, t-butyl or sec-butyl group, or an isopropyl or t-butyl group; Each j is independently 1-6, 1-3, often 1 or 2; Each k is 0 or 1; Each n is independently 1-6, 1-4, 2-4 or 2 or 3; or A pharmaceutically acceptable salt, solute or polymorph thereof. Additional embodiments are directed to pharmaceutical compositions based upon the disclosed chemical compounds and methods of treating or reducing the likelihood of VZV, HSV-1 or HSV-2 infections.

Abstract: Provided herein are non-naturally occurring, broadly reactive antigens derived from influenza viruses that are immunogenic and capable of eliciting a broadly reactive immune response, e.g., a broadly reactive neutralizing antibody response, directed against influenza virus antigens following introduction into a subject. Also provided are non-naturally, broadly reactive immunogens, vaccines, virus particles, virus-like particles (VLPs) and compositions comprising the immunogens and vaccines. Methods of generating an immune response in a human or non-human subject by administering the immunogens, vaccines, VLPs, or compositions thereof are provided. In particular, the immunogens comprise broadly reactive hemagglutinin (HA) protein antigens or soluble HA protein antigens of influenza virus strains, such as H1 or H3.

Abstract: Compositions and methods for improving embryo development, treating idiopathic male factor infertility, and enabling infertile/sub-fertile/sterile men to father their own genetic offspring are provided. Typically, the methods include administering into a male or female gamete or fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein to improve development of an embryo resulting from fertilization of the female gamete by a male gamete. The compound can be administered into the gamete or embryo before, during, or after fertilization. The compound can be administered by an injection such as intracytoplasmic injection. The compound and the male gamete can be administered in combination by intracytoplasmic sperm injection. Methods of making male gametes, and methods of modifying the genome of a male gamete or embryo using an effective amount of a gene editing composition to correct a gene mutation or anomaly in the genome thereof are also provided.

Abstract: Disclosed are various embodiments for an anomaly detection system for detecting and identifying anomalies in electrical devices based on an energy profile associated with the electrical devices. Energy profile data associated with electrical devices or components in a power network can be obtained using an energy meter. The energy profile data can be analyzed to determine one or more conditions of the electrical devices. An anomaly of the electrical devices can be determined based on the energy profile data and conditions. Further, a root cause of the anomaly can be determined.

Abstract: In one embodiment, an assessment system includes an electrical stimulation device configured to generate current, stimulation electrodes configured to apply the current generated by the electrical stimulation device to a neck of a subject at a location that results in stimulation of a phrenic nerve of the subject, a movement sensor configured to sense movement of an upper abdomen of the subject caused by twitching of a diaphragm of the subject responsive to the stimulation of the phrenic nerve, and a controller configured to receive data sensed by the movement sensor, analyze the received data to evaluate the activity of the diaphragm, and generate an assessment of the subject's respiratory function or phrenic nerve.

Abstract: In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

Abstract: Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can by therapeutic and/or prophylactic. The amount of probenecid or a pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.

Abstract: Nitric oxide-releasing materials, methods of making nitric oxide-releasing materials, and uses of nitric oxide-releasing materials are provided. The nitric oxide-releasing materials include a mesoporous silica core and an outer surface having a plurality of nitric oxide donors. In an exemplary aspects, the nitric oxide-releasing material includes a mesoporous diatomaceous earth core, and an outer surface having a plurality of S-nitroso-N-acetyl-penicillamine groups covalently attached thereto. Uses of the nitric oxide-releasing materials can include coatings for medical devices such as catheters, grafts, and stents; wound gauzes; acne medications; and antiseptic mouthwashes; among others.

Abstract: Compounds, compositions, and methods are provided for covalently linking an antibody or an antibody fragment to a cargo molecule, such as a therapeutic or a diagnostic agent, using a combination of enzymatic glycan remodeling and click chemistry. The method allows a cargo molecule to be selectively and efficiently attached post-translationally to an antibody or an antibody fragment. Also provided are antibody drug conjugates, methods of making, and uses thereof.

Abstract: The present disclosure provides devices, kits, and methods for focusing/enriching and/or separating/sorting submicron size particles, including biological entities such as exosomes and other submicron size extracellular vesicles. Devices, kits, and methods of the present disclosure utilize ferrohydrodynamic manipulation to focus populations of submicron particles into a stream for enrichment and/or further sort various sub-populations of submicron particles based on size differences.

Abstract: A heat attenuated infectious bronchitis virus (IBV) isolate of PDRC DMV/1639 deposited at the ATCC under Patent Designation PTA-126757 and progeny and derivatives thereof and compositions thereof are presented. Methods for administering the isolates and compositions as vaccines to prevent virulent IBV infection in birds of the order Galliformes are also presented.

Abstract: Methods and compositions disclosed herein generally relate to genes involved in plant reproduction and methods of using the same.

Abstract: Disclosed herein are oligosaccharides and intermediates useful for the production thereof. The compounds are useful as analytical standards and as intermediates for the preparation of more complex oligosaccharide and N-glycan products. The compounds may be prepared in high purity using the selective stop/go synthetic methods disclosed herein.

Abstract: As disclosed herein, stapled peptides targeting the interaction interface between proteins that maintain the integrity of Wiskott-Aldrich syndrome protein family member 3 (WASF3) leads to destabilization of WASF3 and suppression of invasion. Disclosed are stapled peptides that inhibit the binding of Cytoplasmic FMR1-interacting protein 1 (CYFIP1) to either WASF3 or NCK-associated protein (NCKAP1). Also disclosed are methods for treating or suppressing invasion and metastasis of a cancer in a subject that involve administering to the subject a therapeutically effective amount of a stapled peptide disclosed herein.

Abstract: Various examples of a system for peanut sorting and grading are disclosed herein. The system for grading peanut maturity, can include: a sample feeder configured to supply individual peanuts to an imaging area; a sorting board comprising a plurality of chutes and a plurality of gates, each chute of the plurality of chutes designated for a grade of peanut; and program instructions to obtain the digital image of the individual peanut; determine the grade of the individual peanut; and sort the individual peanut based on the grade of the individual peanut. A method for grading peanut maturity, can include feeding an individual peanut to an imaging area; obtaining a digital image of the individual peanut; determining a grade of the individual peanut based on an average color; and sorting the individual peanut in a chute of a sorting board based on the grade of the individual peanut.

Abstract: A new and distinct cultivar of Thuja plant named ‘RutThu4’, characterized by its compact, globose growth, similar in shape but larger in size and with a faster growth rate than some other Thuja occidentalis cultivars. ‘RutThu4’ also has disease resistance when grown in USDA Zone 8a, and has demonstrated both heat tolerance as well as cold hardiness to about ?34° F. in trials conducted in Minnesota.

Abstract: A new and distinct cultivar of Distylium plant named ‘DISmd-15-18’, characterized by its compact, mounding and evergreen growth habit, and its ovate-elliptical shaped leaves, that are dark green once mature and blueish-purple in color when young. The inventor believes it could be used as a foundation plant in the southern United States.

Abstract: A new and distinct cultivar of Centipedegrass named ‘Tift TC458’ is provided. The new and distinct variety has excellent turf quality, increased seed head production, and increased nematode resistance as compared to similar commercial centipedegrass. The sexually and asexually reproduced diploid variety is reliably propagated both vegetatively and by seed.