Patents Assigned to University of Georgia Research Foundation
  • Patent number: 11274329
    Abstract: Provided herein are plant/plant pathogen volatile compound electrochemical sensors, plant/plant pathogen volatile detection systems, and methods for detecting stress-induced plant volatile compounds and/or a plant-pathogen emitted volatile compounds.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: March 15, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Ramaraja P. Ramasamy, Yi Fang
  • Patent number: 11268041
    Abstract: The present application provides charcoal briquettes infused with a flammable composition including fusel oil and/or one or more dehydration products of fusel oil and the flammable compositions including one or more dehydration products of fusel oil.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: March 8, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Ryan B. Adolphson, Daniel P. Geller, Levi T. Mills, Marcus Leonard Smith, Fredrick W. Huszagh, II
  • Patent number: 11246965
    Abstract: Compositions, devices, grafts and methods for reducing or preventing anti-neointima following cardiovascular injuries and interventions are disclosed. The compositions, devices, and grafts typically include an effective amount of a CTP synthase 1 inhibitor to reduce proliferation of vascular smooth muscle cells, without substantial reducing the proliferation of endothelial cells. Methods of reducing neointima formation, accelerating re-endothelialization, and reducing restenosis in a subject using the compositions, devices, and grafts are also disclosed.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: February 15, 2022
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Shiyou Chen, Rui Tang
  • Publication number: 20220023410
    Abstract: Crimean-Congo hemorrhagic fever (CCHF) virus replicon particles (VRP) are described. These VRP are capable of undergoing a single round of virus replication, but are unable to produce new particles or spread to neighboring cells due to the lack of the glycoprotein-encoding M genome segment. In some instances, the VRP contain one or more mutations in the viral ovarian tumor domain protease encoded by the L genome segment or heterologous antigens within its S genome segment. The VRP are shown to elicit a protective immune response against lethal CCHF virus challenge in an animal model.
    Type: Application
    Filed: December 13, 2019
    Publication date: January 27, 2022
    Applicants: University of Georgia Research Foundation, Inc., THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Eric Bergeron, Scott D. Pegan, Stephen R. Welch, Florine E.M. Scholte, Christina F. Spiropoulou, Stuart T. Nichol, Jessica R. Spengler
  • Patent number: 11229690
    Abstract: The present invention provides genetically engineered strains of the Bordetella species to include one or more mutations preventing expression of the gene encoding the Bordetella Sigma Regulator (also referred to as “bsr,” “btrS,” and “brpL”), compositions and vaccines thereof, and the use of such engineered strains in methods to protect against Bordetella spp, including but not limited to Bordetella bronchiseptica, B. pertussis, B. parapertussis, B. homelsii, or B. avium. In some aspects, the present invention provides the Bordetella bronchiseptica strain RB50?bsr, compositions and vaccines thereof, and the use of Bordetella bronchiseptica strain RB50?fer in methods to protect against Bordetella spp, including but not limited to Bordetella bronchiseptica, B. pertussis, B. parapertussis, B. homelsii, or B. avium.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: January 25, 2022
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Eric T. Harvill, Monica Cartelle Gestal
  • Patent number: 11220516
    Abstract: The present disclosure provides for modified antibiotic compounds, methods of making modified antibiotic compounds, methods of use, products including modified antibiotic compounds, and the like. The modified antibiotic compound comprises a nitric oxide release agent covalently attached to an antibiotic molecule, such as S-nitroso-N-acetylpenicillamine covalently attached to ampicillin.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: January 11, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Hitesh Handa, Sean P. Hopkins, Priyadarshini Singha, Christina Danielle Workman
  • Publication number: 20220001001
    Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from Dengue virus that are immunogenic and elicit a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against Dengue virus subtypes following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, immunogenic compositions, vaccines, subviral particles (SVPs), and virus-like particles (VLPs) comprising Dengue virus proteins or encoding polynucleotides. Methods of generating an immune response in a subject by administering the immunogens, vaccines, SVPs, VLPs, or immunogenic compositions thereof are provided. In particular, the immunogens comprise a Dengue virus protein, or an antibody binding portion thereof.
    Type: Application
    Filed: July 12, 2019
    Publication date: January 6, 2022
    Applicant: University of Georgia Research Foundation
    Inventors: James Daniel Allen, Maria Teresa Arevalo, Ted Milburn Ross, Naoko Uno, Terianne Maiko Wong
  • Patent number: 11207989
    Abstract: Various examples are provided related to wireless charging of electric vehicles. In one example, a wireless charging system includes a transmitter pad including a primary coil supplied by a power source, and alignment control circuitry configured to determine an alignment condition of the transmitter pad with respect to a receiver pad of an electric vehicle. In another example, a wireless charging system includes a receiver pad including a secondary coil; and alignment processing circuitry configured to determine an alignment condition of the receiver pad with respect to a transmitter pad comprising a primary coil supplied by a power source. In another example, a method includes measuring output voltages of a plurality of auxiliary coils mounted on a secondary coil located over a primary coil of the wireless charging system and determining a lateral misalignment between the primary and secondary coils using the output voltages.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: December 28, 2021
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Yabiao Gao, Aleff A. Oliveira, Tsz-Ho Tse
  • Patent number: 11197449
    Abstract: Herein provided is a new runner-type peanut variety designated ‘Georgia-18RU’ as well as the seeds, plants and derivatives of the new peanut variety ‘Georgia-18RU’. Also provided are tissue cultures of the new peanut variety ‘Georgia-18RU’ and the plants regenerated therefrom. Methods for producing peanut plants by crossing the new peanut variety ‘Georgia-18RU’ with itself or another peanut variety (such as another runner-type peanut variety) and plants produced by such methods are also provided. ‘Georgia-18RU’ is a unique runner-type peanut cultivar having a combination of high level of tomato spotted wilt virus (TSWV) resistance and leaf scorch resistance caused by Leptosphaerulina crassiasca (Séchet) Jackson and Bell, and high yield. ‘Georgia-18RU’ provides a medium maturity runner-type peanut cultivar with a prominent main stem, medium green foliage, medium-large runner seed size, and pink seedcoat color.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: December 14, 2021
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventor: William D. Branch
  • Publication number: 20210379180
    Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from H3 influenza virus that are immunogenic and are capable of eliciting a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against H3 vims following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, vaccines, virus-like particles (VLPs) and compositions comprising the immunogens and vaccines. Methods of generating an immune response in a subject by administering the immunogens, vaccines, VLPs, or compositions thereof are provided. In particular, the immunogens comprise the hemagglutinin (HA) protein of H3 influenza vims strains.
    Type: Application
    Filed: July 12, 2019
    Publication date: December 9, 2021
    Applicant: University of Georgia Research Foundation
    Inventors: James Daniel Allen, Ted Milburn Ross, Terianne Maiko Wong
  • Patent number: 11193127
    Abstract: Provided herein is a programmable RNA-activated DNA endonuclease activity associated with a Cmr complex. In one embodiment, the enzyme is a general double-stranded DNA endonuclease. Also provided is a programmable RNA endonuclease activity associated with a Cmr complex. In one embodiment, a Cmr2 protein present in a Cmr complex includes a mutation that reduces RNA-activated DNAse activity of the Cmr complex. In one embodiment, a Cmr4 protein present in a Cmr complex includes a mutation that reduces the RNase activity of the Cmr complex. Compositions including components of a Cmr complex and a CRISPR-RNA, and an optional activating RNA, are provided. Also provided are methods for using the compositions, and genetically engineered cells that include components of a Cmr complex and a CRISPR-RNA, and an optional activating RNA.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: December 7, 2021
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Rebecca M. Terns, Michael P. Terns, Joshua R. Elmore
  • Publication number: 20210371516
    Abstract: Provided herein are antibodies and related polypeptides that bind specifically to CEACAM6. The antibodies and/or polypeptides can be configured as bispecific T cell engagers. The antibodies and/or polypeptides can also be configured as chimeric antigen receptors. Also provided are methods of detection and treatment of cancer, for example, pancreatic cancer, using the antibodies and related polypeptides herein.
    Type: Application
    Filed: February 27, 2018
    Publication date: December 2, 2021
    Applicants: CAERUS THERAPEUTICS, INC., UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: J. Michael PIERCE, Cohava GELBER
  • Patent number: 11174466
    Abstract: The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: November 16, 2021
    Assignees: Commonwealth Scientific and Industrial Research Organisation, University of Georgia Research Foundation, Inc.
    Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
  • Patent number: 11161926
    Abstract: Articles having anti-fogging characteristics, coating compositions providing anti-fogging characteristics, and methods for applying coating compositions with anti-fogging characteristics are described. The coating compositions give a surface or article an anti-fogging characteristic. Articles having such anti-fogging characteristics include those having optical clarity, such as eyewear.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: November 2, 2021
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Jason J. Locklin, Qiaohong Liu
  • Publication number: 20210327533
    Abstract: Provided herein are methods for generating a non-naturally occurring, broadly reactive, pan-epitopic antigen derived from a pathogen, such as a virus, bacterium, and the like, that is immunogenic and is capable of eliciting a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against the pathogen following introduction into a subject. Also provided is a non-naturally occurring immunogen generated using the methods, and vaccines and compositions comprising the immunogen. Methods of generating an immune response in a subject by administering the immunogen, vaccine, or composition are provided. In particular, the immunogen comprises the hemagglutinin (HA) or neuraminidase (NA) protein of influenza virus strains.
    Type: Application
    Filed: July 12, 2019
    Publication date: October 21, 2021
    Applicant: University of Georgia Research Foundation
    Inventors: James Daniel Allen, Ted Milburn Ross, Terianne Maiko Wong, Anne Gaelle Bebin Blackwell, Ivette Ariela Nunez, Zachary Beau Reneer, Ying Huang
  • Patent number: PP33754
    Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-1797’, characterized by a combination of early season flowering and ripening, large berries with good color and flavor, high quality fruit production in conventional production areas, and a chilling requirement of about 200-300 hours below about 45° F.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: December 21, 2021
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Patent number: PP33755
    Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-1493’, characterized by a combination of early season flowering and ripening, large berries with good color and flavor, high quality fruit production in conventional production areas, and a chilling requirement of about 350-450 hours below about 45° F.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: December 21, 2021
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Patent number: PP33782
    Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-1872’, characterized by a combination of early season flowering and ripening, large berries with good flavor and firmness, high quality fruit production in conventional production areas, and a low chilling requirement of about 150-200 hours below about 45° F.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: December 28, 2021
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Patent number: PP33868
    Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-920’, characterized by a combination of early-to-mid season ripening; large berries with good scar and flavor and high fruit quality; moderately vigorous growth suited to home gardens, soft pink flowers at opening, bronze coloring to newly emerging foliage, berries transitioning from pink hued to sky-blue during ripening; and a chilling requirement of about 500-550 hours below about 45° F.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: January 18, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Patent number: PP33869
    Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-889’, characterized by a combination of later season flowering and ripening; large berries with unique, vibrant light blue color and good flavor and firmness; vigorous growth; compact form; attractive fall foliage color; and a chilling requirement of about 500-600 hours below about 45° F.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: January 18, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith