Abstract: A method of wet spinning poly (3,4-ethylenedioxythiopene):poly (styrenesulfonate) or PEDOT:PSS fibers produces PEDOT:PSS fibers having a unique combination of electrical conductivity, thermal conductivity and Young's modulus properties.
Type:
Grant
Filed:
November 21, 2019
Date of Patent:
November 23, 2021
Assignee:
University of Kentucky Research Foundation
Abstract: Provided are method for treating age-related macular degeneration (AGE), and/or preventing the occurrence or progression thereof in a subject in need thereof. In some embodiments, the methods include administering to the subject in need thereof a composition that has an effective amount of an inhibitor of reverse transcriptase (RTase) activity. Also provided are methods for protecting retinal pigmented epithelium (RPE) cells, retinal photoreceptor cells, and/or choroidal cells; methods for treating geographic atrophy of the eye, and/or for preventing occurrence or progression thereof; and pharmaceutical compositions for treating AGE and/or GA and/or for preventing the occurrence or progression thereof; and/or for protecting RPE cells, retinal photoreceptor cells, and/or choroidal cells.
Type:
Application
Filed:
October 9, 2019
Publication date:
November 11, 2021
Applicants:
University of Virginia Patent Foundation, University of Kentucky Research Foundation
Inventors:
Jayakrishna Ambati, Bradley David Unti Gelfand, Nagaraj Kerur, Shinichi Fukuda, Kameshwari Ambati, Benjamin Fowler
Abstract: Provided herein are a glucan kinase polypeptide, an isolated polynucleotide, and a method for processing starch. The glucan kinase polypeptide comprises an isolated polypeptide including a sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO:22, fragments thereof, variants thereof, and combinations thereof. The isolated polynucleotide comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 21, a fragment thereof, a variant thereof, and a combination thereof. The method for processing starch comprises providing a glucan dikinase; exposing a starch to the glucan dikinase; and collecting the starch that has been exposed to the glucan dikinase.
Type:
Grant
Filed:
March 29, 2018
Date of Patent:
October 26, 2021
Assignee:
University of Kentucky Research Foundation
Abstract: The present invention concerns a process of selective precipitation for the purpose of recovering rare earth elements from acidic media derived from coal and coal byproducts via two main steps of sequential precipitation and selective precipitation. An intermediary step of re-precipitation can be included to further increase RRE concentrations, as well as improve contaminant metal removal.
Type:
Grant
Filed:
November 9, 2018
Date of Patent:
October 26, 2021
Assignee:
University of Kentucky Research Foundation
Abstract: A system and method is provided for producing linear and branched hydrocarbons and in particular triterpenes in plant cells. The system and method includes a transformed plant cell with an isolated nucleic acid encoding a farnesyl diphosphate synthase (FPS) and with an isolated nucleic acid encoding a triterpene synthase.
Type:
Grant
Filed:
October 3, 2012
Date of Patent:
October 19, 2021
Assignee:
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.
Type:
Grant
Filed:
July 15, 2019
Date of Patent:
October 12, 2021
Assignees:
North Carolina State University, University of Kentucky Research Foundation
Inventors:
Ralph E. Dewey, Balazs Siminszky, Steven W. Bowen, Lily Gavilano
Abstract: A nanoscale conductor/semiconductor/insulator device includes a substrate with a lattice and a plurality of nanotubes in crystallographic alignment with the lattice at an interface between the plurality of nanotubes and the substrate. Another such device includes a substrate, meandering tracks in the substrate and a plurality of nanotubes adhering to cut-atomic-step edges of the meandering tracks. Methods of making the nanoscale conductor/semiconductor/insulator devices are also disclosed.
Type:
Grant
Filed:
August 30, 2019
Date of Patent:
October 5, 2021
Assignee:
University of Kentucky Research Foundation
Inventors:
Mohsen Nasseri, Armin Ansary, Mathias J. Boland, Douglas R. Strachan
Abstract: The invention herein concerns a catalyst of gold particles on a layered double hydroxide (LDH) that assists in oxidation of alcohols in lignins. In some embodiments, the LDH comprises lithium and aluminum metals. Also considered are methods of using the catalyst to oxidize lignins and methods of preparing the catalyst.
Type:
Grant
Filed:
December 28, 2018
Date of Patent:
September 21, 2021
Assignee:
University of Kentucky Research Foundation
Inventors:
Mark Crocker, Yang Vanessa Song, Justin Mobley
Abstract: Methods for determining the presence of pathologic amylin in a subject with diabetes or pre-diabetes are provided herein. The method includes obtaining a skin sample from a subject and determining if there is pathologic amylin present in the skin sample.
Type:
Grant
Filed:
April 26, 2019
Date of Patent:
August 31, 2021
Assignee:
University of Kentucky Research Foundation
Abstract: A method of treating pain is disclosed, which involves administering an effective amount of lapatinib or a pharmaceutically-acceptable salt thereof to a subject in need of treatment for pain.
Type:
Grant
Filed:
November 6, 2019
Date of Patent:
August 31, 2021
Assignee:
University of Kentucky Research Foundation
Abstract: A method of killing bacteria and an antibiotic kit are provided herein. The method includes treating the bacteria with a DNA condensation-inducing compound; and subsequently treating the bacteria with an Eis inhibitor. The kit includes a DNA condensation-inducing compound packaged together with an Eis inhibitor.
Type:
Grant
Filed:
July 22, 2019
Date of Patent:
August 31, 2021
Assignees:
University of Kentucky Research Foundation, Academisch Medisch Centrum
Inventors:
Sylvie Garneau-Tsodikova, Nicole Neeltje van der Wel
Abstract: Electrodes for rechargeable batteries that include silicon and a binder are provided. Binders for use with silicon electrodes are provided, including polysiloxane binders that can be prepared prior to preparation of the electrode, or provided as monomers to be cure-polymerized at the time of the curing of the electrode.
Type:
Grant
Filed:
July 18, 2017
Date of Patent:
August 17, 2021
Assignee:
University of Kentucky Research Foundation
Inventors:
Susan A. Odom, Darius A Shariaty, Yang-Tse Cheng
Abstract: The presently-disclosed subject matter relates to RNA-based composition and method to treat breast cancer in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure and composition containing a multiple branched RNA nanoparticle, a breast cancer targeting module, and an effective amount of a breast cancer therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanoparticle composition to treat breast cancer in a subject having or at risk of having breast cancer.
Type:
Grant
Filed:
March 9, 2016
Date of Patent:
August 10, 2021
Assignee:
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Inventors:
Peixuan Guo, Dan Shu, Yi Shu, Hui Li, Farzin Haque
Abstract: The present invention is directed towards an artificial RNA nanostructure comprising multiple external strands of RNA, each external strand comprising about 40-50 nucleotides; one internal strand of RNA comprising more than about 50 nucleotides; the internal strands and external strands assembled to form a triangle nanostructure, a square nanostructure, or a polygon nanostructure and a pRNA three-way junction (3WJ) motif at each vertex of the nanostructure. Such nanostructure can be provided in a composition together with an adjuvant for use in inducing the production of high affinity neutralizing antibodies or inhibitory antibodies, inducing the production of cytokines, inducing an immune response in a subject, or a combination thereof.
Type:
Grant
Filed:
February 1, 2019
Date of Patent:
July 13, 2021
Assignee:
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Inventors:
Peixuan Guo, Hui Li, Emil Khisamutdinov, Daniel Jasinski
Abstract: Non-toxigenic fungal strains, and methods of making and use thereof, are provided and have utility as endophytes in forage crops, and as strains that can outcompete toxigenic strains in forage and food crops.
Type:
Grant
Filed:
June 1, 2017
Date of Patent:
June 1, 2021
Assignee:
University of Kentucky Research Foundation
Inventors:
Christopher L. Schardl, Simona Florea, Mark L. Farman
Abstract: A method is described for the identification of multi-subunit biocomplex drug targets. The method includes identifying a target that performs a biological function, wherein the target comprises one or more subunits, wherein a minimum number of the one or more subunits is inactivated to inhibit the biological function. The method includes selecting a drug that binds specifically to each subunit of the one or more subunits with a target probability. The method describes a relationship between inhibition efficiency of the drug and total number of the one or more subunits using a binomial distribution, wherein the inhibition efficiency comprises a probability that the delivered drug blocks the biological function. The method includes confirming empirically the relationship using an experimental target. The method includes administering the drug to the target to treat a multi-drug resistant disease, wherein the target comprises a biological complex in a mammalian subject.
Type:
Grant
Filed:
May 6, 2016
Date of Patent:
April 13, 2021
Assignee:
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
Abstract: Compounds for use as electrolyte in a non-aqueous redox battery are provided, including an N-substituted phenothiazine compound according to the formula: R? is alkyl and R is selected from alkyl, aryl, alkylaryl, alkoxyaryl, alkylcarboxyl, arylcarbonyl, haloalkyl, perfluoroalkyl, glycol, polyether, haloaryl, a negative electrolyte, a polymerizable unit, and a polymer.
Type:
Grant
Filed:
August 22, 2017
Date of Patent:
March 23, 2021
Assignee:
University of Kentucky Research Foundation
Inventors:
Susan A. Odom, Aman Preet Kaur, Matthew D. Casselman, N. Harsha Attanayake
Abstract: Novel devices and methods of capturing, controlling and preventing infestation of insects using microfabricated surfaces are provided. In particular, a mechanism of insect capture inspired by the microstructures of the leaf surfaces of plants and the key features of those surfaces with respect to the capture and control of pests have been determined and engineered into a variety of microfabricated surfaces capable of reproducing the effectiveness of these physical capture methods.
Type:
Grant
Filed:
September 24, 2018
Date of Patent:
July 27, 2021
Assignees:
The Regents of the University of California, The University of Kentucky Research Foundation
Inventors:
Catherine Loudon, Robert Corn, Megan Szyndler, Kenneth F. Haynes, Michael F. Potter