Abstract: Methods for modulating eye damage associated with a disease or disorder, and/or damage incident to trauma including but not limited to trauma associated with ocular surgery are provided. In some embodiments, the methods include administering an effective amount of a modulator of a migration inhibitory factor (MIF) polypeptide biological activity to a subject. Also provided are methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of an ocular disease, and methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of scarring and/or other consequence of wound healing incident to ocular surgery, as well as modulating the survival, function, and/or differentiation of engrafted cells that can be employed as part of tissue engineering procedures to correct structural, functional, and/or cellular defects of the eye.
Type:
Grant
Filed:
May 20, 2011
Date of Patent:
October 13, 2015
Assignee:
University of Lousiville Research Foundation, Inc.
Inventors:
Tongalp H. Tezel, Henry J. Kaplan, Robert A. Mitchell, John O. Trent
Abstract: The presently-disclosed subject matter provides sensors and methods for detecting volatile organic compounds (VOCs) by determining the conductivity of a chemiresistant film upon exposure to VOCs, including for example chemiresistant films comprised of surfactant-coated metal alloy nanoparticles.
Type:
Grant
Filed:
July 26, 2008
Date of Patent:
April 10, 2012
Assignee:
University of Lousiville Research Foundation, Inc.
Inventors:
Francis P. Zamborini, Francisco J. Ibanez