Abstract: Method of inhibiting a protein-protein interaction between Von Hippel-Lindau tumor-suppressor protein and hypoxia-inducible factor 1-alpha useful in the treatment of angiogenesis-related diseases and promoting wound healing.

Abstract: Disclosed are a parallel multi-converter and a capacity design method therefor. A first output current model and a second output current model are generated by respectively acquiring electrical parameters of an inductive voltage source converter and a capacitive voltage source converter, and the first output current model and the second output current model are integrated under the same output current condition, so that it may be ensured that the inductive voltage source converter and the capacitive voltage source converter have the same current generating ability; meanwhile, a coupling inductance relationship between the inductive voltage source converter and the capacitive voltage source converter is combined to further obtain the optimal capacity value of the inductive voltage source converter and the optimal capacity value of the capacitive voltage source converter. Therefore, the L-VSC and the LC-VSC have the same current generating ability, and the multi-converter has lower total voltage capacity.

Abstract: The present disclosure discloses a fiber Bragg grating displacement sensor with positive and negative bidirectional measurement and free from vibration, which falls within the technical fields of fiber sensing and measurement monitoring, and aims to solve the problem that the measuring range of the existing fiber Bragg grating displacement sensor is positive, and the free end of the cantilever beam will generate vibration deformation, resulting in inaccurate displacement measurement. The sensor of the present disclosure has a positive and negative two-way displacement measurement range through the arrangement of a bidirectional measuring mechanism. In the measurement process, the cantilever beam of the vibration-avoiding mechanism is in an initial state of zero deformation, resulting in upper and lower bending deformation, so as to avoid the fatigue and failure problems caused by the cantilever beam and the fiber Bragg grating due to constant force.

Abstract: Disclosed are an attitude estimation method, a terminal, a system and a computer-readable storage medium. For the problem of attitude and sensor bias estimation, a cascade solution method is provided. The first part of the cascade is a Kalman filter applied to an LTV system, and the second part of the cascade is a nonlinear attitude observer built in SO(3). In the estimation process, only one constant inertial reference vector needs to be measured explicitly in body-fixed coordinates, and the complexity of the attitude estimation algorithm is greatly simplified by exploiting the geometric relationship between the inertial reference vector and the Earth angular velocity vector. At the same time, the time-varying characteristics of the implemented Kalman filter help to avoid the tedious empirical gain adjustment process that often relies on sets of piecewise constant gains, to improve the convergence speed of the algorithm.

Abstract: A novel piezo-driven cell injection system with force feedback overcomes the unsatisfied force interaction between the pipette needle and embryos in conventional position control. By integrating semiconductor strain-gage sensors for detecting the cell penetration force and the micropipette relative position in real time, the developed cell microinjection system features high operation speed, confident success rate, and high survival rate. The effectiveness of the developed cell injection system is experimentally verified by penetrating zebrafish embryos. The injection of 100 embryos are conducted with separate position control and force control. Results indicate that the force control enables a survival rate of 86%, which is higher than the survival rate of 82% produced by the position control in the same control environment. The experimental results quantitatively demonstrate the superiority of force control over conventional position control for the first time.

Abstract: Disclosed is a method for preparing supramolecular cell-based carrier, which relates to the technical fields of supramolecular chemistry, supramolecular materials and cell preparations. Host-guest interactions mediated supramolecular cell-based carriers can achieve targeted delivery based on cell physiological functions, and have high biocompatibility, physiological barrier permeability, and targeting delivery efficiency. It does not require covalent bond modification on the cell surface, and has no effect on the physiological functions of transporting cells. The preparation method of supramolecular cell-based carrier provided by the present application has the advantages of simple and fast construction process, mild conditions and universal applicability, and the method has bio-orthogonality. In addition, a drug loading system is also provided, which can realize drug loading for targeted therapy.

Abstract: The present disclosure provides a system comprising a SPECT or PET device; a CT device; and a computer comprising memory and a processor in communication with the memory, the memory comprising a computer application program for a method of performing dosimetric analysis of an organ. The computer application program is executable by the processor to perform the method. The method comprising receiving single photon emission computed tomography (SPECT) or positron emission tomography (PET) images at time instances, the SPECT or PET images relating to the organ. The method then receives a computed tomography (CT) image at one of the time instances, the CT image relating to the organ. Virtual CT images are then generated at the other time instances based on the received SPECT or PET images and the CT image. An absorbed dose of ionising radiation on the organ can then be measured based on the received SPECT or PET images, the received CT image, and the generated virtual CT images.

Abstract: Provided is an apparatus, system and method for on-chip microfluids dispensing. The apparatus comprising a substrate; a plurality of first electrodes arranged one next to another on the substrate; a dielectric layer above and enclosing the plurality of first electrodes; and a second electrode on the substrate, wherein each of the plurality of first electrodes is in electric communication with a respective first driving signal input; wherein the second electrode is in electric communication with a second driving signal input; wherein the plurality of first electrodes define a continuous fluid path along a longitudinal direction for retaining microfluids, and wherein the second electrode is arranged within the continuous fluid path and defines a jetting position and an adjacent mixing position within the continuous fluid path.

Abstract: The present disclosure provides a control system of a buck converter, relating to the field of Internet of Things. The control system of a buck converter provided in an embodiment of the present disclosure includes a first control module, a second control module, and a mode selector. The first control module is turned on and the second control module is turned off through an analog current sensor in the mode selector when an IoT device switches from a transmission mode to a sleep mode or a standby mode, so that the first control module outputs a first voltage pulse to the driving and level shifter module, wherein a frequency of the first voltage pulse is determined by a frequency of a first clock in the first control module, and a width of the first voltage pulse is determined by a frequency of a second clock in the first control module.

Abstract: Provided is a digital microfluidic device for quick polymerase chain reaction. The digital microfluidic device includes an enclosed chamber for holding droplets comprising PCR mixtures. The chamber has an upper layer and a lower layer, which provide a top heater and a bottom heater contained in a thermal electrode respectively to form dual heaters. The lower layer further has an array of electrodes and a dielectric layer, e.g. Norland Optical adhesive 61, coating thereon. Such arrangement of the digital microfluidic device allows quick and homogeneous heating of droplets to lower the heating voltage, shorten the reaction time, and prevent the dielectric layer from breakdown during the thermal cycle.

Abstract: The present disclosure discloses use of mesenchymal stem cells in preparation of a formulation for promoting fat transplantation, relating to the field of biotechnologies. The inventors found through research that compared with MSCs derived from somatic cells, MSCs derived from human pluripotent stem cells have more stable quality, are not affected by donor's physical quality, disease and treatment process, and can promote fat transplantation by enhancing tissue remodeling, angiogenesis and adipose cell survival and decreasing tissue fibrosis.

Abstract: The present disclosure discloses use of scutellarin in a medicament and a modulator for preventing or treating diseases, a medicament, and a modulator, which is related to the technical field of medicine. The present disclosure discloses use of scutellarin in the preparation of a medicament for preventing or treating a disease caused or mediated by interaction between TNF and TNFR2. The research in the present disclosure has shown that scutellarin is capable of selectively inhibiting TNF-induced death of WEHI-13VAR cells and significantly inhibiting TNF-induced proliferation of Tregs, accompanied with down-regulation of TNFR2 and Foxp3 expression in Tregs. This indicates that scutellarin can be used to treat or prevent relevant diseases caused or mediated by the interaction between TNF and TNFR2, and the present disclosure provides a new idea or means for preventing or treating relevant diseases caused or mediated by the interaction between TNF and TNFR2.

Abstract: An exemplary embodiment of the present invention is a wireless power transmission circuit that provides power to a load of variable resistance with an alternating current (AC) power source induced at a secondary coil in a secondary side of the circuit by a primary coil in a primary side of the said circuit. The wireless power transmission circuit includes a switch-controlled capacitor (SCC) and a semi-active rectifier (SAR). The SCC connects to the AC power source. The SCC includes a first capacitor connected in parallel with two electrically controllable switches in series. The SAR connects to output of the SCC for rectifying the output of the SCC, wherein the SAR comprises a bridge circuit that includes two electrically controllable switches. A control angle of the SCC and a conduction angle of the SAR are regulated to provide a load impedance that matches the impedance of the coils.

Abstract: A method of differentiating pluripotent stem cells into mesenchymal stem cells, a culture medium used in the method of differentiating pluripotent stem cells into mesenchymal stem cells and a method of performing tissue and organ regeneration by using the mesenchymal stem cells obtained by differentiation using the method of differentiating pluripotent stem cells into mesenchymal stem cells are provided. The method of differentiating pluripotent stem cells into mesenchymal stem cells comprises differentiating, completely under 3D suspension conditions, pluripotent stem cells into trophoblast-like cells using BMP4 and A8301, and then differentiating the trophoblast-like cells into mesenchymal stem cells. Neither of two differentiation processes needs passaging or replacement of a culture container.

Abstract: Angiotensin II (AngII) has been strongly implicated in hypertension and its complications. Evidence suggests the mechanisms by which angiotensin II (AngII) elevates blood pressure and enhances cardiovascular remodeling and damage may be distinct. In vascular smooth muscle cells, a metaloproteinase ADAM17 mediates epidermal growth factor receptor (EGER) transactivation, which may be responsible for cardiovascular remodeling but not hypertension induced by AngII. Treatment with a human cross-reactive ADAM17 inhibitory antibody (A9B8) also prevented cardiovascular, remodeling and ER stress but not hypertension in C57Bl/6 mice infused with AngII. In vitro data further supported these findings. In conclusion, vascular ADAM17 mediates AngII-induced cardiovascular remodeling via EGFR activation independent of blood pressure regulation. ADAM17 presents a unique therapeutic target for antibodies such as A9B8 for the prevention of hypertensive complications.

Abstract: Disclosed are compositions and methods for treatment of a disease or disorder of the eye and adnexa of the eye, including dry eye disease and Sjögren's syndrome, by administering a composition comprising an indole and a flavonoid either as an admixture or as a synthetic heterodimer thereof.

Abstract: Various embodiments of the present technology generally relate to a single monolithic IC to perform simultaneous optogenetic neural inhibition and extracellular electrophysiological recording in-vivo. Some embodiments include a low input capacitance (e.g., 9.7 pF) amplifier particularly tailored for the use of high-impedance electrodes to conduct single neuron extracellular recording integrated with programmable high current drivers for optogenetic stimulation or inhibition on the same IC chip. Some embodiments use a noise model to guide the IC design process to obtain parameters for optimal signal-to-noise ratio. The performance of the IC chip was demonstrated on an anesthetized gerbil expressed with inhibitory optogenetic protein (Halorhodopsin). Spontaneous action potentials from the fifth nerve of the brainstem were recorded by the amplifier and were subsequently inhibited by laser illumination.

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of tumor amongst all human cancers due to late diagnosis and resistant to treatment with chemotherapy and radiation. Preclinical and clinical studies have revealed that ErbB family for example epidermal growth factor receptor (EGFR) is a validated molecular target for pancreatic cancer prevention and therapy. The ErbB signaling cascade is regulated by a member of the ADAM (a disintegrin and metalloprotease) family, namely ADAM17, by enzymatic cleavage of precursor ligands into soluble cytokines and growth factors. Mouse genetic studies have demonstrated that ADAM17 is required for PDAC development. In this study, we evaluated the anti-tumor effects of A9(B8) IgG—the first specific ‘human and mouse cross-reactive’ ADAM17 inhibitory antibody on pancreatic malignant transformation. We found that inhibition of ADAM17 with A9(B8) IgG efficiently suppressed the shedding of ADAM17 substrates both in vivo and in vitro.

Abstract: Multi-mode resonator is usually used to design broadband bandpass filters and the cross-shape resonator (CSR) is one of its typical types. The possibility of utilizing cross-shape multi-mode resonators is explored as a signal controller for superconducting qubits that are coplanar to the resonator. The multi-mode qubit-resonator coupling facilitates the design of future quantum information processor.

Abstract: The present disclosure discloses use of scutellarin in a medicament and a modulator for preventing or treating diseases, a medicament, and a modulator, which is related to the technical field of medicine. The present disclosure discloses use of scutellarin in the preparation of a medicament for preventing or treating a disease caused or mediated by interaction between TNF and TNFR2. The research in the present disclosure has shown that scutellarin is capable of selectively inhibiting TNF-induced death of WEHI-13VAR cells and significantly inhibiting TNF-induced proliferation of Tregs, accompanied with down-regulation of TNFR2 and Foxp3 expression in Tregs. This indicates that scutellarin can be used to treat or prevent relevant diseases caused or mediated by the interaction between TNF and TNFR2, and the present disclosure provides a new idea or means for preventing or treating relevant diseases caused or mediated by the interaction between TNF and TNFR2.