Abstract: Glycosylated antitumor ether lipids (GAELs) are effective cytotoxic agents against cancer stem cells. Furthermore, combining GAELs which kill cells by a caspase-independent pathway with agents that kill cells by apoptosis will lead to elimination of the differentiated tumor cells and the undifferentiated cancer stem cells leading to an elimination of the tumor and preventing recurrence.

Abstract: Although Fiber Reinforced Polymers (FRPs), as alternatives for the corrosive steel reinforcement in concrete structures, have shown promising performance under gravity loads, their performance under reversal cyclic loading is still one of the main concerns. The linear behavior of FRP reinforcement has a two-sided effect on the seismic performance of FRP-reinforced concrete (RC) moment-resisting frames. Although the linear nature of FRP reinforcement could be advantageous in terms of limiting the residual damage after an earthquake event, it lowers the energy dissipation of the structure which can compromise its seismic performance. Disclosed herein is the addition of steel plates at selected locations in moment-resisting frames to improve seismic performance of FRP-RC structures while still being able to take advantage of its linear behaviour (minimal residual damage after earthquake). The effectiveness of the proposed solution was tested both experimentally and analytically.

Abstract: A method for electromagnetic imaging of containers receives uncalibrated first data corresponding to signals of a first plurality of different frequencies associated with an antenna array residing in a container having contents. The method estimates of a second data based on a computer model and simulation of signals of a second plurality of different frequencies associated with the antenna array, the second plurality of different frequencies including a subset of the first plurality of different frequencies. The method compares magnitudes, without corresponding phase comparisons, of the first and second data at each frequency of the second plurality of different frequencies. The method updates the second data based on the comparing. The method provides information about the contents within the container based on the updated second data.

Abstract: Provided herein are plants that reduce growth of a fungal pathogen, increase resistance of the plant to a fungal pathogen, or a combination thereof. The plant includes a polynucleotide that reduces expression of a coding region present in a fungal pathogen, such as Sclerotinia sclerotiorum or Botrytis cinerea. The polynucleotide can be present on the surface of the plant, expressed by a plant, or a combination thereof. Also provided are methods of making and methods of using the plants.

Abstract: The present disclosure relates to a compound that has biocidal activity or is a precursor of a compound with biocidal activity. The compound comprises an N-halamine precursor, at least one quaternary ammonium and at least one coating-incorporation group (CIG). In some embodiments of the present disclosure, the compound may be incorporated into a coating formulation. The coating formulation comprises the compound and at least one further component. In some embodiments of the present disclosure, the CIG reacts with the further component of the coating formulation to incorporate the compound into the coating formulation. In some embodiments, the coating formulation comprises a polymer. In some embodiments, the CIG of the compound reacts with the further component to incorporate the compound into the polymer of the coating formulation. The coating formulation may be used to coat a substrate. The coated substrate may demonstrate biocidal activity or the potential for increased biocidal activity.

Abstract: A single-rod hydrostatic actuator or pump-controlled actuator, comprises a hydrostatic pump connected in a closed circuit to a single-rod hydraulic cylinder where the cylinder velocity is directly controlled by the pump flow, without the need of intermediary valves. Due to the absence of throttling losses, the efficiency of hydrostatic actuators is considerably superior to the efficiency of conventional valve-controlled circuits. However, because of the differential areas at the cap and rod sides of the cylinder, the flows coming into and out of the cylinder do not match. Several attempts have been made to this date to produce a stable, robust and reliable circuit that can be used in everyday applications but no circuit has ever been conceived to reach the high standards of reliability and robustness required by industry. The current invention solves the problem of the differential flows with a design that is reliable, oscillation-free and robust.

Abstract: A modified surface with at least one cationic center and at least one compound. The surface can be modified by various methods. The result of these methods is that the cationic center and the compound are connected to the modified surface. The cationic center and the compound are connected to the modified surface so that both of the cationic center and the compound are available upon the modified surface to react with other chemicals or microorganisms that come into contact with or near to the modified surface. The availability of the cationic center and the compound cause the modified surface to have a functionality that it would not otherwise have. The number of molecules of the cationic center relative to the number of molecules of the at least one compound may influence the functionality of the modified surface.

Abstract: Bacteria-responsive core-shell nanofibers and a process for the preparation thereof are described. The nanofibers release of an antibacterial agent in response to the presence of bacteria. The core of the nanofiber comprises a biocompatible polymer together with an antibacterial agent such as a quaternary ammonium compound, for example benzyl dimethyl tetradecyl ammonium chloride (BTAC). Surrounding the core is shell comprised of a bacterially degradable polymer, which is susceptible to break-down by bacterial enzymes such as lipase, or to acidic pH conditions. The shell may comprise, for example, polycaprolactone (PCL) and poly(ethylene succinate) (PES). The nanofibers may be incorporated into wound dressings.

Abstract: Pump-controlled hydraulic circuits are more efficient than valve-controlled circuits, as they eliminate the energy losses due to flow throttling in valves and require less cooling effort. Presently existing pump-controlled solutions for single rod cylinders encounter an undesirable performance during certain operating conditions. Novel circuit designs employ use of different charge pressures on a pair of pilot-operated charging-control valves or different piston areas and/or spring constants on a shuttle-type charging control valve to shift a critical loading region in a load-force/actuator-velocity plane to a lower load force range, thereby reducing the undesired oscillations experienced in the response of the typical critical loading region.

Abstract: Detection of intravascular plaque in OCT images is carried out by obtaining images of vascular tissue from a vascular component by OCT either in a static mode of a single image or in a dynamic mode where the images are obtained by scanning. The method acts by dividing the OCT image into different regular regions, calculating different texture features for each of the above regions with a reduced set of less than a full set of the 26 Haralick textural features, using a clustering algorithm to segment the image defined by its texture features calculated above into different regions and transforming the segmented image back from its representation using texture features to its space-domain representation. The method uses three or four texture features where the reduced sets can be f1, f 2, and f14 (ASM at 0°, Inertia at 0° and ASM at 90°).

Abstract: The present disclosure relates to using a compound as a reactant in one or more chemical reactions for making intermediate compounds or reaction-product compounds that includes at least one cyclic N-halamine precursor group and at least one cationic center. The compound has the general formula (1): Wherein Z is either N or Y and when Z is N then R1 and R2 are each independently selected from a group of methyl, ethyl or n-propyl. When Z is Y then R1 and R2 are both nil and Y is selected from Cl, Br and I. The reaction-product compound may have biocidal activity and/or it may have increased biocidal activity following one or more chemical-modification reactions.

Abstract: A low cost and efficient damage detection method is developed by introducing a new piezoelectric composite coating combined with a self-powered wireless signal transmission module. The new piezoelectric composite coating composed with a piezoelectric layer, an electrical conductive layer and an insulator, is designed as the sensor and to be easily applied on rough surfaces of engineering structures, such as concrete and the welded joint area. An energy harvesting circuit and an automatic electronic switch controlled by the piezoelectric coating sensor are designed to power and control the wireless signal transmitter sending warning signals of the damage occurrence. Methodology is explained in detail, and successful detection of the occurrence of crack propagation on a beam structure has been realized through experimental testing.

Abstract: A method for synthesizing a reagent complex includes a step of ball-milling a mixture that includes: a powder of a zero-valent element; a hydride molecule; and a nitrile ligand. The method produces a reagent complex having a formula Q0.Xy.Lz, where Q0 is the zero-valent element, X is the hydride molecule, and L is the nitrile ligand. A process for synthesizing nanoparticles composed of the zero-valent element includes a step of adding solvent to the reagent complex. Crystal texture of the nanoparticles is modulated by appropriate selection of the molar ratio nitrile ligand in the reagent complex.

Abstract: Low cost and low power LED lamps exhibit current harmonic contents due to their nonlinear characteristics. A large scale lighting network requires tens to hundreds LED lamp installations, the resultant harmonic currents pollute the grid seriously. Furthermore, light intensity fluctuations are becoming a concern nowadays to many users, as a safety and a health problems. This phenomenon is mainly caused by heavy loads as they lead to voltage fluctuations and deteriorating in PQ and hence visual flickering in LED lamps. A single phase transformer-less unified power quality conditioner (UPQC) topology is provided with its controls to mitigate all PQ problems in a network.

Abstract: Exemplary methods and systems may image an object of interest using one or more waveguide assemblies including gated elements. The gated elements may be configurable in a transmission state, a reception state, or a passive state. The exemplary methods and systems may deliver electromagnetic energy (e.g., microwave energy) to an object of interest using a gated element of a waveguide assembly configured in a transmission state and sample scattered field using a gated element of another waveguide assembly configured in the reception state while the remainder of gated elements are configured in the passive state.

Abstract: A new tri-electrode topology reduces the control voltage requirement for electrostatic actuators. Conventional parallel plate actuators are dual-electrode systems, formed by the MEMS structure and the drive electrode. By placing a perforated intermediate electrode between these elements, a tri-electrode configuration is formed. This topology enables a low voltage on the intermediate electrode to modulate the electrostatic force of the higher voltage drive electrode, whose voltage remains fixed. Results presented show that in comparison to conventional parallel plate electrostatic actuators, the intermediate electrode's modulating voltage can be as low as 20% of normal, while still providing the full actuation stroke.

Abstract: A novel methodology for computing the medial axis/skeleton of a discrete binary object using a ‘divide and conquer’ algorithm, in which any 3D object is first sliced into a series of 2D images in X, Y and Z directions. Then, a geometric (Voronoi) algorithm is applied on each 2D image to extract the respective medial axis. This information is then combined to reconstruct the medial axis of the original 3D object using an intersection technique. An optional 3D interpolation step to achieve continuous connected skeletons uses Delaunay triangles and a spherical search to establish the nearest neighboring points in 3D space to interpolate between. Test results show that the proposed 3D Voronoi and optional interpolation algorithms are able to accurately and efficiently extract medial axes for complex 3D objects as well. Finally, an axis-smoothing algorithm using the same Delaunay triangle and spherical test is operable to remove unwanted noise from the extracted medial axis.

Abstract: Provided herein are FDC-SP polypeptides and methods of using such polypeptides. Methods include, but are not limited to, altering IgA concentration in a subject, treating a subject having signs of a disorder that includes excessive IgA production, identifying a compound that decreases the concentration of IgA in an animal, and identifying a compound that treats a condition associated with increased levels of IgA. Also provided herein is an animal that has decreased expression of an endogenous FDC-SP coding sequence. The animal may develop pathophysiological features of IgA nephropathy, and/or may display increased IgA in serum, saliva, bronchoalveolar lavage fluid, or a combination thereof; increased IgA expressing B lymphocytes in circulation, lymphoid tissue, or a combination thereof; or increased IgA production in vitro by isolated B lymphocytes.

Abstract: Embodiments herein include variants of ?-hexosaminidase that are useful for hydrolyzing GM2 ganglioside, polynucleotides encoding the same, and related methods. In various embodiments, a variant ?-hexosaminidase subunit is included wherein the variant ?-hexosaminidase subunit forms a homodimer under physiological conditions and wherein the variant ?-hexosaminidase subunit associates with GM2 activator protein to hydrolyze GM2 ganglioside. In some embodiments, an isolated or recombinant polynucleotide encoding such a variant ?-hexosaminidase subunit is included. In some embodiments, a method of treating a subject exhibiting an abnormal cellular accumulation of GM2 ganglioside is included wherein the method includes administering a composition including a protein variant of ?-hexosaminidase or a polynucleotide encoding the same. Other embodiments are included herein.

Abstract: A bidirectional bridgeless buck-boost power converter circuit is provided that can function as both a voltage source inverter (VSI) circuit to transform direct current (DC) voltage to alternating current (AC) voltage and as a power factor corrector (PFC) circuit to transform AC voltage to DC voltage. The disclosed converter fully utilizes inductors to form a CL filter and buck-boost converter energy storage element. Thus, low inductance chokes are used in the converter, which leads to a higher power density and is more cost-effective. Further, the bridgeless configuration minimizes conduction losses of semiconductors, and coupled with the use of low inductance chokes this improves system efficiency.