Patents Assigned to University of Massachusetts, Amherst Campus
  • Cloning using donor nuclei from differentiated fetal and adult cells
    Publication number: 20050108785
    Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated cell nuclei into enucleated oocytes of the same species as the donor cell is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring, and for production of isogenic CICM cells, including human isogenic embryonic or stem cells. Production of genetically engineered or transgenic mammalian embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
    Type: Application
    Filed: September 2, 2004
    Publication date: May 19, 2005
    Applicant: University of Massachusetts, Amherst Campus
    Inventors: Steven Stice, Jose Cibelli, James Robl, Paul Golueke, F. de Leon, D. Jerry
  • Cloning using donor nuclei from differentiated fetal and adult cells
    Publication number: 20020010949
    Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated cell nuclei into enucleated oocytes of the same species as the donor cell is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring, and for production of isogenic CICM cells, including human isogenic embryonic or stem cells. Production of genetically engineered or transgenic mammalian embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
    Type: Application
    Filed: April 10, 2001
    Publication date: January 24, 2002
    Applicant: University of Massachusetts, Amherst Campus
    Inventors: Steven L. Stice, Jose Cibelli, James Robl, Paul Golueke, F. Abel Ponce de Leon, D. Joseph Jerry
  • CICM cells and non-human mammalian embryos prepared by nuclear transfer of a proliferating differentiated cell or its nucleus
    Patent number: 6235970
    Abstract: An improved method of nuclear transfer involving the transplantation of donor differentiated cell nuclei into enucleated oocytes of the same species as the donor cell is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring, and for production of isogenic CICM cells, including human isogenic embryonic or stem cells. Production of genetically engineered or transgenic mammalian embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: May 22, 2001
    Assignee: University of Massachusetts, Amherst Campus
    Inventors: Steven L. Stice, Jose Cibelli, James Robl, Paul Golueke, F. Abel Ponce de Leon, D. Joseph Jerry