Patents Assigned to University of Michigan
  • Patent number: 11987737
    Abstract: A metamaterial shell architected on a core particle (comprising organic or inorganic material) so as to form a novel class of structurally hierarchical particle that has degrees of freedom in design parameters stemming from effective optical response of the metamaterial shell and from the electromagnetic modes in the core to elicit optical behaviours that are not easily achievable and designable in particles having simpler or smoother geometries.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: May 21, 2024
    Assignees: California Institute of Technology, The Regents of the University of Michigan
    Inventors: Alireza Marandi, Joon Hwan Bang, Saman Jahani, Nicholas Kotov, Douglas G. Montjoy
  • Patent number: 11986352
    Abstract: A method of estimating lung motion includes collecting multiple ultrasound image data captured at one or more locations of a sample region of tissue. The method further includes comparing the multiple ultrasound image data and determining temporal correlation coefficients between each of the multiple ultrasound image data. The method still further includes displaying an image of the sample region of the tissue with the temporal correlation coefficients identified, thereby indicating lung motion. In further methods, the determined temporal correlation coefficients are used to determine an amount of decorrelation, which can be used to determine strain of the tissue over the sample region and to calculate lung displacements and lung shape changes representing ventilation.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: May 21, 2024
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jonathan M. Rubin, James D. Hamilton, Oliver D. Kripfgans, J. Brian Fowlkes
  • Patent number: 11986993
    Abstract: The disclosure relates to methods of forming three-dimensional (3D) polymeric articles and additive manufacturing apparatuses for the same. The methods include providing a polymeric solution comprising a polymer dissolved in a solvent; providing a non-solvent, wherein the solvent is miscible in the non-solvent, and the polymer is insoluble in the non-solvent; and injecting the polymeric solution into the non-solvent in a pre-determined 3D pattern to provide a 3D polymeric article.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: May 21, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Henry A. Sodano, Ruowen Tu, Ethan Cassidy Sprague
  • Patent number: 11984208
    Abstract: Methods comprising an integrated, multiscale artificial intelligence-based system that reconstructs drug-specific pharmacogenomic networks and their constituent functional sub-networks are described. The system uses features of the functional topology of the three-dimensional architecture of drug-modulated spatial contacts in chromatin space. Discovery of a drug pharmacogenomic network is made through the selection of candidate SNPs by imputation, determination of the predicted causality of the SNPs using machine learning and deep learning, use of the causal SNPs to probe the spatial genome as determined by chromosome conformation capture analysis, combining targeted genes controlled by the same cell and tissue-specific enhancers, and reconstruction of the pharmacogenomic network using diverse data sources and metrics based on the results of genome-wide association studies.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: May 14, 2024
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Brian D. Athey, Gerald A. Higgins, Alex Ade, Alexandr Kalinin, Narathip Reamaroon, James S. Burns
  • Patent number: 11981603
    Abstract: Printable cementitious compositions for additive manufacturing are provided, that have a fresh state and a hardened state. In fresh state, the composition is flowable and extrudable in the additive manufacturing process. In the hardened state, the composition exhibits strain hardening. In one variation, the strain hardening is represented by a uniaxial tensile strength of ?about 2.5 MPa, a tensile strain capacity of ?about 1%, and a compressive strength at 100 hours of ?about 20 MPa. In other variations, the composition includes Portland cement, a calcium aluminate cement, a fine aggregate, water, a high range water reducing agent (HRWRA), and a polymeric fiber, as well as one or more optional components selected from: fly ash, silica flour, microsilica, attapulgite nanoclay, and/or hydroxypropylmethyl cellulose (HPMC). Methods of additive manufacturing with such compositions are also provided.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: May 14, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Daniel G. Soltan, Victor C. Li
  • Patent number: 11981700
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: May 14, 2024
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Patent number: 11985888
    Abstract: An organic light emitting device (OLED) comprises an anode; a cathode; and a light emitting layer, disposed between the anode and the cathode; wherein the light emitting layer comprises at least one luminescent compound; and wherein the transition dipole moment of the at least one luminescent compound is oriented parallel to the surface of the light emitting layer. A method of fabricating a light emitting layer, comprises the steps of providing a substrate; depositing less than 2 nm of a template material on the substrate; and depositing a composition comprising at least one light emitting compound on the template material.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: May 14, 2024
    Assignee: The Regents of the University of Michigan
    Inventors: Stephen R. Forrest, Jongchan Kim
  • Patent number: 11974757
    Abstract: An anti-hemorrhage device, and an anti-hemorrhage kit, includes a rigid platform and a compression device adjustably secured to the rigid platform. The kit also includes a gastroesophageal aortic occlusion device.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: May 7, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jeffrey Stephen Plott, Kevin R. Ward
  • Publication number: 20240143164
    Abstract: A system is presented for detecting gestures. The system is comprised of: a contact microphone and a signal processor. The contact microphone is attached to a surface of interest of an objection and is configured to measure surface acoustic waves traveling along the surface of interest. The signal processor is interfaced with the contact microphone and is configured to receive a signal from the contact microphone, where the signal is indicative of surface acoustic waves traveling along the surface of interest. The signal processor operates to identify a gesture made by a person on the surface of interest using the signal.
    Type: Application
    Filed: October 31, 2023
    Publication date: May 2, 2024
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Yasha IRAVANTCHI, Alanson SAMPLE
  • Patent number: 11970684
    Abstract: The disclosure relates to bioreactors, for example for biological treatment and, more specifically to bioreactor insert apparatus including biofilms and related methods. The bioreactor insert apparatus provides a means for circulation of reaction medium within the bioreactor, a biofilm support, and biological treatment of an inlet feed to die reactor/insert apparatus. The bioreactor insert apparatus has a high relative surface area for biofilm attachment and is capable of generating complex flow patterns and increasing treatment efficiency/biological conversion activity in a biologically-active reactor. The high surface area structure incorporates multiple biofilm support structures such as meshes at inlet and outlet portions of the structure. The biofilm support structures and biofilms thereon can increase overall reaction rate of the bioreactor and/or perform some solid/liquid separation in the treatment of the wastewater or other influent.
    Type: Grant
    Filed: January 12, 2023
    Date of Patent: April 30, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Steven Skerlos, Lutgarde Raskin, Timothy Fairley-Wax, Nishant Jalgaonkar
  • Patent number: 11973182
    Abstract: Disclosed are electrochemical devices, such as lithium ion battery electrodes, lithium ion conducting solid-state electrolytes, and solid-state lithium ion batteries including these electrodes and solid-state electrolytes. Also disclosed are methods for making such electrochemical devices.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: April 30, 2024
    Assignees: The Regents of the University of Michigan, Board of Trustees of Michigan State University
    Inventors: Jeffrey Sakamoto, Travis Thompson, Isabel N. Boona
  • Publication number: 20240137389
    Abstract: A computer-implemented method is presented for detecting non-compliance with an opt-out decision of a user. The method includes: identifying select statements of a privacy policy for an online tracking entity by analyzing webpages associated with the online tracking entity, where the select statements specify data practices in response to an opt-out decision; detecting transfer of cookies from a web browser to a server, where the cookies are transferred after an opt-out decision by the given user and the server is associated with the given online tracking entity; analyzing content of the detected cookies in relation to the select statements of the privacy policy; and notifying the given user of a violation of the privacy policy in response to determining an inconsistency between the content of the detected cookies and the select statements of the privacy policy.
    Type: Application
    Filed: October 12, 2023
    Publication date: April 25, 2024
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Kang G. SHIN, Hoang Duc BUI
  • Publication number: 20240132770
    Abstract: An engineered cementitious composite (ECC) has a tensile strain capacity ranging from 8.6 to 12.5% and includes a cement precursor, unprocessed desert sand, and polymer fibers. The polymer fibers may be ultra-high molecular weight polyethylene fibers, polypropylene fibers, or a combination thereof. A method of preparing an ECC structure includes providing a cementitious precursor mixture including a cement precursor and unprocessed desert sand, introducing water into the cementitious precursor mixture to form a cement slurry, and adding polymer fibers to the cement slurry. The polymer fibers may be ultra-high molecular weight polyethylene fibers, polypropylene fibers, or a combination thereof. Then, the method includes forming a structure with the cement slurry and curing the cement slurry.
    Type: Application
    Filed: October 13, 2022
    Publication date: April 25, 2024
    Applicants: SAUDI ARABIAN OIL COMPANY, University of Michigan
    Inventors: Mohammed Al Mehthel, Victor Li, He Zhu, Thibault Villette, Waleed Nasser, Oscar Salazar Vidal
  • Publication number: 20240133038
    Abstract: Methods of forming a structural color metal-dielectric-metal (MDM) component via a solution-based process are provided. First, a first metal layer is formed over a treated surface of a substrate by a first electroless deposition process. A surface of the treated substrate is contacted with a first plating bath that comprises a metal selected from the group consisting of: copper, aluminum, silver, alloys, and combinations thereof. A dielectric layer, for example, comprising silicon dioxide, is then deposited over the first metal layer by a sol-gel process. Next, the method comprises forming a second metal layer over the dielectric layer by a second electroless deposition process by contacting the dielectric layer with a second plating bath having a neutral pH and comprising a metal selected from the group consisting of: copper, aluminum, silver, alloys, and combinations thereof.
    Type: Application
    Filed: October 18, 2023
    Publication date: April 25, 2024
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, NINGBO INLIGHT TECHNOLOGY CO., LTD.
    Inventors: Lingjie Jay GUO, Weijie FENG, Chengang JI
  • Patent number: 11965112
    Abstract: An anti-icing coating is provided having low interfacial toughness (LIT) with ice. The anti-icing coating includes a polymer and a plasticizing agent. A thickness of the anti-icing coating may be less than or equal to about 100 micrometers (?m). Further, the anti-icing coating has an interfacial toughness (?ice) with ice of less than or equal to about 1 J/m2. Such an anti-icing coating may be applied to a substrate or surface of a device on which ice may form, such as aircraft, vehicles, marine vessels, outdoor equipment, snow or ice removal equipment, recreational equipment, wind turbines, telecommunications equipment, power lines, and the like. Methods of forming such anti-icing coatings are also provided.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: April 23, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Anish Tuteja, Michael Thouless, Kevin Golovin, Abhishek Dhyani
  • Patent number: 11960298
    Abstract: An integrated speed prediction framework based on historical traffic data mining and real-time V2I communications for CAVs. The present framework provides multi-horizon speed predictions with different fidelity over short and long horizons. The present multi-horizon speed prediction is integrated with an economic model predictive control (MPC) strategy for the battery thermal management (BTM) of connected and automated electric vehicles (EVs) as a case study. The simulation results over real-world urban driving cycles confirm the enhanced prediction performance of the present data mining strategy over long prediction horizons. Despite the uncertainty in long-range CAV speed predictions, the vehicle level simulation results show that 14% and 19% energy savings can be accumulated sequentially through eco-driving and BTM optimization (eco-cooling), respectively, when compared with normal-driving and conventional BTM strategy.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: April 16, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Mohammad Reza Amini, Yiheng Feng, Zhen Yang, Ilya Kolmanovsky, Jing Sun
  • Patent number: 11958137
    Abstract: Due to geometric discontinuities introduced by welding and joining processes, stresses or strain cannot be calculated reliably calculated using modern analytical and computer methods as result of stress or strain singularity at joint locations, which leads to severe mesh sensitivity. Design and fatigue evaluation of these structures remain empirical. This disclosure addresses mesh insensitivity of stress/strain calculations for welded structures through a cut-plane traction stress method through a novel post processing of conventional finite element computation results, as well as provides a unified fatigue evaluation procedure for fatigue design and structural life evaluation for both low-cycle and high cycle fatigue regime subjected to either proportional or non-proportional multiaxial fatigue loading, as well as a simple and reliable method for treating spot welds.
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: April 16, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Pingsha Dong, Xianjun Pei, Jifa Mei
  • Patent number: 11961621
    Abstract: A method includes receiving patient health data; determining a score using a trained machine learning model; determining a threshold value using an adaptive threshold tuning learning model; comparing the score to the threshold value; and generating an alarm. A computing system includes a processor; and a memory having stored thereon instructions that, when executed by the processor, cause the computing system to: receive patient health data; determine a score using a trained machine learning model; determine a threshold value using an adaptive threshold tuning learning model; compare the score to the threshold value; and generate an alarm. A non-transitory computer readable medium includes program instructions that when executed, cause a computer to: receive patient health data; determine a score using a trained machine learning model; determine a threshold value using an adaptive threshold tuning learning model; compare the score to the threshold value; and generate an alarm.
    Type: Grant
    Filed: February 10, 2023
    Date of Patent: April 16, 2024
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Christopher Elliot Gillies, Daniel Francis Taylor, Kevin R. Ward, Fadi Islim, Richard Medlin
  • Patent number: 11952679
    Abstract: Inverse temperature crystallization processes are provided to produce perovskite single crystals (PSCs), as well as surface passivation techniques for producing stabilizing the PSCs in the bulk region. Stable hybrid perovskite material include a bulk region comprising a single crystal perovskite material having a first bandgap and a smooth perovskite surface layer having a second bandgap greater than the first bandgap. Devices for detection and energy conversion are also contemplated, including for spectroscopic photon and elementary particle detection, such as radiation detectors. Crystallization chambers for forming the PSCs are also provided.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: April 9, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Suneel Joglekar, Lingjie Jay Guo, Mark David Hammig
  • Patent number: 11953459
    Abstract: A multi-functional sensor assembly includes an electrically non-conductive substrate defining at least a distal region, intermediary region, and proximal region that are each covered with electrically conductive traces. The proximal region is configured to be exposed to a media to be sensed and the distal and intermediary regions are configured to be protected from the media. The electrically conductive traces comprise at least electrical circuits to sense temperature and flow of the media and one or more electrodes to sense one or more of conductivity, oxidation reduction potential (ORP), and acidity (pH) of the media.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: April 9, 2024
    Assignees: MASCO CORPORATION, The Regents of the University of Michigan
    Inventors: Klaus Brondum, Mark Andrew Burns, Wen-Chi Lin, Michael McCague, Stephen Michael Stec, Brian N. Johnson, Garry Marty