Abstract: The present invention provides a novel isolated and purified fungus Hirsutella minnesotensis. The present invention also provides a pesticidal composition of an effective amount of an isolated and purified fungal strain of Hirsutella rhossiliensis or Hirsutella minnesotensis that is capable of controlling nematode infestation and a carrier. Further, the present invention provides methods of controlling nematode infestation.

Abstract: Compositions that include tissue factor incorporated into lipid vesicles are described, as well as compositions that include enzymes other than factor VIIa that directly activate factor X to Xa in solution without directly supporting thrombin generation. Such compositions do not produce thrombogenic levels of thrombin in human patient and can be used to increase clot formation in patients in need thereof.

Abstract: Provided is a transgenic non-human eukaryotic animal whose germ cells and somatic cells contain the amyloid precursor protein sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage. In mice, an age-related CNS disorder characterized by agitation, neophobia, seizures, inactivity, diminished cerebral glucose utilization, cortico-limbic gliosis, and death, develops. An acceleration of this disorder occurs in transgenic mice expressing human and mouse Alzheimer amyloid precursor proteins (APP) produced using a hamster prion protein gene-derived cosmid vector that confers position-independent, copy number-dependent expression. In transgenic mice the disorder develops in direct relationship to brain levels of transgenic APP, but mutant APP confers the phenotype at lower levels of expression than wild-type APP. The disorder occurs in the absence of extracellular amyloid deposition, indicating that some pathogenic activities of APP are dissociated from amyloid formation.

Abstract: Biopolymers and biopolymer blends, including block copolymers, prepared via enzyme-mediated catalysis preferably in a microorganism host in which the reaction conditions are selected to produce biopolymers and biopolymer blends having particular chemical compositions and microstructures.

Abstract: The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.