Patents Assigned to University of Nebraska
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Patent number: 11484374Abstract: The various robotic medical devices include robotic devices that are disposed within a body cavity and positioned using a support component disposed through an orifice or opening in the body cavity. Additional embodiments relate to devices having arms coupled to a device body wherein the device has a minimal profile such that the device can be easily inserted through smaller incisions in comparison to other devices without such a small profile. Further embodiments relate to methods of operating the above devices.Type: GrantFiled: October 8, 2019Date of Patent: November 1, 2022Assignee: Board of Regents of the University of NebraskaInventors: Eric Markvicka, Tom Frederick, Jack Mondry, Joe Bartels, Shane Farritor
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Patent number: 11464574Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.Type: GrantFiled: September 24, 2018Date of Patent: October 11, 2022Assignee: Board of Regents of the University of NebraskaInventors: Hani Haider, Ibrahim Al-Shawi, Osvaldo Andres Barrera
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Patent number: 11458136Abstract: The present invention provides prodrugs and methods of use thereof.Type: GrantFiled: April 9, 2019Date of Patent: October 4, 2022Assignee: Board of Regents of the University of NebraskaInventors: Howard E. Gendelman, Benson Edagwa
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Patent number: 11447753Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.Type: GrantFiled: May 6, 2020Date of Patent: September 20, 2022Assignees: Northwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College (AKA Tufts University)Inventors: Gregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
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Patent number: 11446067Abstract: Systems and methods are described for treating distal radius fractures using a plating system. In an aspect, a distal radius plating system includes a volar plate body for interfacing with a volar side of a distal portion of a radius bone. The volar plate body has a volar head portion extending from the volar plate body and terminating at a distal edge, the volar head portion including a first set of apertures to receive fixation fasteners therethrough to fix to the radius bone. The distal radius plating system also includes a radial longitudinal portion extending from a radial edge of the volar plate body to interface with the radial styloid of the radius bone while the volar plate body is positioned on the volar side of the distal portion of the radius bone.Type: GrantFiled: March 1, 2019Date of Patent: September 20, 2022Assignee: The Board of Regents of The University of NebraskaInventor: Daniel Firestone
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Publication number: 20220294448Abstract: A magneto-electric (ME) XNOR logic gate device includes a conducting device; and a ME-FET coupled to the conducting device. The ME-FET can be formed of a split gate; a first gate terminal coupled to a first portion of the split gate for receiving a first input signal; a second gate terminal coupled to a second portion of the split gate for receiving a second input signal; a source terminal coupled to a ground line; and a drain terminal coupled to the conducting device.Type: ApplicationFiled: May 29, 2022Publication date: September 15, 2022Applicants: Board of Regents of the University of Nebraska, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Intel CorporationInventors: Nishtha Sharma GAUL, Andrew MARSHALL, Peter A. DOWBEN, Dmitri E. NIKONOV
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Publication number: 20220294449Abstract: A magneto-electric (ME) majority gate device includes a conducting device and a plurality of ME transistors coupled to the conducting device. In one implementation, the plurality of ME transistors include a ME AND gate device with downward interface polarization, a ME-transmission gate device with downward interface polarization, and a ME-XNOR gate device. In another implementation, the plurality of ME transistors is five single-input ME-FETs.Type: ApplicationFiled: May 29, 2022Publication date: September 15, 2022Applicants: Board of Regents of the University of Nebraska, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Intel CorporationInventors: Nishtha Sharma GAUL, Andrew MARSHALL, Peter A. DOWBEN, Dmitri E. NIKONOV
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Publication number: 20220294450Abstract: A magneto-electric (ME) inverter includes two anti-ferromagnetic spin orbit read (AFSOR) circuit elements, each AFSOR circuit element has a CMOS inverter; and an AFSOR device with a ME base layer; a semiconductor channel layer on the ME base layer and comprising a source terminal and a drain terminal, where the source terminal is coupled to an output of the CMOS inverter; and a gate electrode on the semiconductor channel layer. The gate electrode of a second AFSOR device of the two AFSOR circuit elements is coupled to the drain terminal of a first AFSOR device of the two AFSOR circuit elements.Type: ApplicationFiled: May 29, 2022Publication date: September 15, 2022Applicants: Board of Regents of the University of Nebraska, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Intel CorporationInventors: Nishtha Sharma GAUL, Andrew MARSHALL, Peter A. DOWBEN, Dmitri E. NIKONOV
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Patent number: 11427936Abstract: Expanded, nanofiber structures are provided as well as methods of use thereof and methods of making.Type: GrantFiled: September 19, 2018Date of Patent: August 30, 2022Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventor: Jingwei Xie
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Patent number: 11420027Abstract: The present application includes a sheath that is suitable for use in a variety of medical procedures. In one or more implementations, the sheath includes a shunt member, and a curvable portion. The curvable portion may be configured in various orientations to facilitate an intervention, such as a hemodialysis intervention, or the like, by an operator. The curvable portion may be configured to bend between a substantially straight configuration and a curved configuration. In implementations, the sheath may be configured to have detachable and/or interchangeable components (e.g., shunt member, curvable portion, etc.).Type: GrantFiled: November 12, 2019Date of Patent: August 23, 2022Assignee: Board of Regents of the University of NebraskaInventor: Gregory Gordon
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Patent number: 11406458Abstract: The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices.Type: GrantFiled: August 13, 2019Date of Patent: August 9, 2022Assignee: Board of Regents of the University of NebraskaInventors: Tom Frederick, Eric Markvicka, Shane Farritor, Dmitry Oleynikov
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Patent number: 11386998Abstract: Disclosed herein are embodiments of systems and techniques for estimating the severity of chronic obstructive pulmonary disease (COPD) in a patient. For example, in some embodiments, a system for estimating COPD severity in a patient may include logic to receive a breathing signal representative of breathing activity of the patient over a time interval, receive a locomotion signal representative of locomotive activity of the patient over the time interval, and provide breathing data and locomotion data to additional logic, wherein the additional logic is to generate an estimate of COPD severity in the patient by comparison of 1) a cross-recurrence quantification analysis (cRQA) parameter between the breathing data and the locomotion data and 2) a reference value. The breathing data may be based on the breathing signal, and the locomotion data may be based on the locomotion signal.Type: GrantFiled: August 6, 2015Date of Patent: July 12, 2022Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Nicholas Stergiou, Jennifer Yentes, Stephen I. Rennard, Amol Patil, William Denton
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Publication number: 20220213502Abstract: The present invention provides in general methods for transdifferentiation of a somatic cell, e.g., a fibroblast, to a dopaminergic precursor. Specifically, the present invention relates to methods for making iDP cells, and methods for using them in, e.g., treating neurodegenerative diseases such as Parkinson's disease.Type: ApplicationFiled: January 18, 2022Publication date: July 7, 2022Applicants: Tongji University, Board of Regents of the University of NebraskaInventors: Jialin Zheng, Changhai Tian
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Patent number: 11370769Abstract: Provided herein are TRPC5 inhibitors and methods of using the same, e.g., to protect podocytes and/or treat kidney disease.Type: GrantFiled: September 7, 2018Date of Patent: June 28, 2022Assignees: Board of Regents of the University of Nebraska, The Brigham and Women's Hospital, Inc.Inventors: Corey Hopkins, Anna Greka
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Patent number: 11369397Abstract: A number of improvements to laparoscopic devices are described herein, primarily to improve the ergonomic functionality of the devices. For example, an articulating rod system is described, a gripping mechanism is described, and an end effector is described.Type: GrantFiled: February 1, 2013Date of Patent: June 28, 2022Assignee: Board of Regents of the University of NebraskaInventors: M. Susan Hallbeck, Jakeb Riggle, Adam de Laveaga, Jake Kaufman
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Patent number: 11369449Abstract: A surgical robot can be configured for minimally invasive surgery (MIS) and other types of surgery with modular link geometry and disposable components. In some examples, the surgical robot includes a cable driver comprising at least one drive motor configured for tensioning a cable. The surgical robot includes an articulated surgical tool coupled to the drive motor by the cable. The articulated surgical tool comprises at least first and second articulated links and a joint coupling the first and second articulated links. The cable passes through the joint, and the joint comprises an elastic antagonist biased in opposition to tension from the cable to allow bidirectional actuation of the joint. The surgical robot includes a safety lock configured to lock the joint from allowing articulation of the first and second articulated links in response to a loss of tension in the cable.Type: GrantFiled: September 20, 2019Date of Patent: June 28, 2022Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Carl A. Nelson, Nicholas Nelson
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Patent number: 11357595Abstract: Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a first arm link operably coupled to the base, a second arm link operably coupled to the first arm link, a third arm link operably coupled to the second arm link, and a slidable coupling component slidably coupled to the third arm link.Type: GrantFiled: November 22, 2017Date of Patent: June 14, 2022Assignee: Board of Regents of the University of NebraskaInventors: Mark Reichenbach, Shane Farritor
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Patent number: 11361678Abstract: The present disclosure is directed to a system and method for surgical training with low cost, reusable materials and a highly customizable virtual environment for skill-building. According to various embodiments, a surgical training tool is usable in conjunction with a support structure configured to at least partially constrain the tool movement. Meanwhile, the tool is tracked in real-time with off-tool detectors to generate a tool path driving a virtual rendering of the surgical training tool in an operative environment. The virtual rendering may be visually observable via a display device and may include a customizable and/or selectable operative environment with one or more structures that can be operated on by the virtual surgical training tool. By tracking the virtual tool interaction with the virtual structures, a task path may be established for documenting and/or objectively assessing the performance of one or more operative tasks.Type: GrantFiled: June 6, 2014Date of Patent: June 14, 2022Assignee: Board of Regents of the University of NebraskaInventors: Ka-Chun Siu, Carl Nelson, Mohsen Zahiri, Dmitry Oleynikov
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Patent number: 11351153Abstract: An antimicrobial composition containing a synergistic combination of an imidazole antifungal agent and activated creatinine is provided, wherein the imidazole antifungal agent represents in the range of about 0.5 mol % to about 30 mol % of the combination of the antifungal agent and the activated creatinine in the composition. Methods for treating bacterial infections, fungal infections, viral infections, and wounds are also provided, as are other methods of use, including methods for disinfecting inert surfaces, methods for preserving food products, and methods for treating plants. In addition, the invention provides a method for enhancing the antifungal effect of an imidazole antifungal agent as well as a method for enhancing the antibacterial effect of activated creatinine. Compositions and methods involving use of activated 2-amino-imidazol-4-one analogs other than activated creatinine are also provided.Type: GrantFiled: December 27, 2017Date of Patent: June 7, 2022Assignee: Board of Regents of the University of NebraskaInventors: Thomas McDonald, Steven M. Tracy
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Patent number: 11349480Abstract: Logic circuits constructed with magnetoelectric (ME) transistors are described herein. A ME logic gate device can include at least one conducting device, for example, at least one MOS transistor; and at least one ME transistor coupled to the at least one conducting device. The ME transistor can be a ME field effect transistor (ME-FET), which can be can be an anti-ferromagnetic spin-orbit read (AFSOR) device or a non-AFSOR device. The gates and logic circuits described herein can be included as standard cells in a design library. Cells of the cell library can include standard cells for a ME inverter device, a ME minority gate device, a ME majority gate device, a ME full adder, a ME XNOR device, a ME XOR device, or a combination thereof.Type: GrantFiled: September 24, 2019Date of Patent: May 31, 2022Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, INTEL CORPORATIONInventors: Nishtha Sharma Gaul, Andrew Marshall, Peter A. Dowben, Dmitri E. Nikonov