Abstract: Disclosed herein are cyclodextrin molecules covalently modified to store and release nitric oxide, as well as methods of making and uses thereof. The covalently modified cyclodextrin molecules may be tailored, in several embodiments, to release nitric oxide in a controlled manner and are useful for reduction and/or eradication of bacteria and for the treatment of disease.

Abstract: Disclosed herein are isotactic polyvinyl ethers and improved methods of making same. The method disclosed herein can produce polyvinyl ethers having a higher isotacticity as compared to polyvinyl ethers prepared with conventional methods.

Abstract: The presently disclosed subject matter describes the use of fluorinated elastomer-based materials, in particular perfluoropolyether (PFPE)-based materials, in high-resolution soft or imprint lithographic applications, such as micro- and nanoscale replica molding, and the first nano-contact molding of organic materials to generate high fidelity features using an elastomeric mold. Accordingly, the presently disclosed subject matter describes a method for producing free-standing, isolated nanostructures of any shape using soft or imprint lithography technique.

Abstract: Disclosed herein are methods and compositions comprising an adeno-associated virus 2.5 (AAV2.5) capsid protein, comprising one or more amino acids substitutions, (e.g., which does not contain a substitution at the position corresponding to amino acid 267 of AAV2.5, or does not contain a serine at the position corresponding to amino acid 267 of AAV2.5) wherein the substitutions introduce a new glycan binding site into the AAV capsid protein.

Abstract: A method for processing digital subtraction angiography (DSA) or computed tomography (CT) images for reduced radiation exposure to a DSA or CT subject includes receiving, as input, a plurality of captured DSA or CT image frames of a contrast agent flowing through a volume of interest in a subject. The method further includes fitting a mathematical model to measured contrast agent density of individual voxels of the captured DSA or CT image frames to produce a mathematical model of contrast agent flow across the captured DSA or CT image frames. The method further includes sampling the mathematical model of contrast agent flow for the individual voxels to produce reconstructed DSA or CT image frames. The method further includes outputting at least one of the reconstructed CT or DSA image frames.

Abstract: Methods, systems and devices that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer.

Abstract: Chondroitin sulfate compounds comprising chondroitin sulfate backbone 19 mer, CS-A 19 mer, CS-C 19 mer, CS-E 19 mer, C8 backbone 13 mer, C8-A 13 mer, CS-C 13 mer, CS-E 13 mer and/or combinations thereof are provided. Methods of treating histone toxicity in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the histone toxicity in the subject. Pharmaceutical compositions for use in treating histone toxicity and/or sepsis are provided. Methods of treating sepsis in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the sepsis in the subject.

Abstract: The disclosure of a compound of Formula (I) or a pharmaceutically acceptable salt thereof (I) The variables W, R1, R2, R3, and R4 are defined in the disclosure. The disclosure provides a compound or salt of Formula (I) together with a pharmaceutically acceptable carrier. The disclosure also provides methods of treating a patient for Parkinson's disease and related syndromes, dyskinesia, especially dyskinesias secondary to treating Parkinson's disease with L-DOPA, neurodegenerative disorders such as Alzheimer's disease and dementia, Huntington's disease, restless legs syndrome, bipolar disorder and depression, schizophrenia, cognitive dysfunction, or substance use disorders, the methods comprising administering a compound of Formula I or salt thereof to the patient. The disclosure provides combination methods of treatment in which the compound of Formula (I) is administered to the patient together with one or more additional active agents.

Abstract: Viral promoters and compositions and methods of use thereof are provided. Compositions include viruses with impaired ability to reactivate from latency, and pharmaceutical compositions and method of use thereof. The genome of the viruses include one or more mutations that reduce expression from one or more promoters that regulate expression of viral genes during reactivation from latency. The mutation(s) are typically in a region of the viral genome that includes (i) promoter elements of the iP1 promoter of human cytomegalovirus, or the sequence of another virus corresponding thereto (e.g., an iP1 promoter homolog); (ii) promoter elements of the iP2 promoter of human cytomegalovirus, or sequence of another virus corresponding thereto (e.g., an iP2 promoter homolog); or (iii) a combination thereof. In some embodiments the virus encodes one or more heterologous antigens. The viruses can be used as vaccines to induce prophylactic and therapeutic immune responses in subjects in need thereof.

Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.

Abstract: Systems and methods for measuring micro-architectural properties of vascular networks are described herein. An example method can include injecting an ultrasound contrast agent into a medium, and transmitting a plurality of acoustic pulses into the medium using a ultrasound transducer array. Each respective acoustic pulse can be transmitted from one or more elements of the ultrasound transducer array. The method can also include receiving a plurality of backscattered signals with the ultrasound transducer array in response to each respective acoustic pulse, and obtaining a response matrix including the backscattered signals. The method can further include extracting a coherent or incoherent contribution to the backscattered signals from the response matrix, and quantifying a property of a vascular network based on the coherent or incoherent contribution to the backscattered signals.

Abstract: Phase-incrementing MRSI (pi-MRSI) method has resolved overlapping biomarker images in the presence of a read-gradient. On a Bruker 9.4T MRI spectrometer, the pi-SEE-HSelMQC sequence was implemented. The choline-selective and lactate CH-selective RF pulses were phase incremented by 10° in opposite signs, synchronized with the phase-encoding steps. The lactate and choline images from a yogurt phantom displayed opposite image offsets without image overlapping. In vivo one-dimensional pi-SEE-HSelMQC CSI images of lactate and choline, acquired from the MDA-MB-231 human breast cancer xenograft in a nude mouse, as well as two-dimensional pi-SEE-HSelMQC imaging of lactate and choline acquired from the PC3 human prostate cancer xenograft in a nude mouse, also had opposite image offsets, shifted away from the spurious residual water signals in the image center. The pi-SEE-HSelMQC method completely suppresses lipid and water with potential clinical applications in disease diagnosis and therapeutic interventions.

Abstract: A system for estimating maximum heart rate and maximal oxygen uptake from submaximal exercise intensities can include an exercise intensity monitor, a cardiopulmonary monitor, and one or more computers. The computers can be configured, by virtue of appropriate programming, to receive submaximal exercise intensity data from the exercise intensity monitor and submaximal cardiopulmonary data from the cardiopulmonary monitor while a user, who coupled to the exercise intensity monitor and the cardiopulmonary monitor, is performing an exercise at a submaximal exercise intensity. The one or more computers then determine a heuristic estimate of a maximal cardiopulmonary state of the user based on the submaximal exercise intensity data and the submaximal cardiopulmonary data.

Abstract: The invention generally relates to methods of making substituted arenes via direct C—H amination. More specifically, methods of making para- and ortho-substituted arenes via direct C—H amination are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Provided are antibodies, and fragments and derivatives thereof, particularly humanized derivatives thereof, which bind to tumor antigens. Also provided are nucleic acid molecules encoding chimeric antigen receptors (CARs) that bind to tumor antigens, polypeptides and CARs encoded by the nucleic acid molecules, vectors and host cells that include the nucleic acid molecules, methods of making the same, and methods for using the same to generate a persisting population of genetically engineered T cells in a subject, expanding a population of genetically engineered T cells in a subject, modulating the amount of cytokine secreted by a T cell, reducing the amount of activation-induced calcium influx into a T cell, providing an anti-tumor immunity to a subject, treating a mammal having a MUC1-associated disease or disorder, stimulating a T cell-mediated immune response to a target cell population or tissue in a subject, and imaging a MUC1-associated tumor.

Abstract: A system, mixing-enhanced microfluidic container, and methods for small volume sample collection and/or analysis is disclosed. Namely, the invention is directed to a small volume sample collection system that includes a mixing-enhanced microfluidic container and a durable reusable actuation chuck. The mixing-enhanced microfluidic container is used to collect small volumes of sample fluid and includes a means for mixing the sample fluid with reagents disposed within the microfluidic container. The mixing means utilize an array of surface-attached structures (e.g., a micropost array). The application of an “actuation force,” such as a magnetic or electric field, actuates the surface-attached structures into movement, wherein the actuation chuck in close proximity to the mixing-enhanced microfluidic container provides the “actuation force.

Abstract: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.

Abstract: The present invention is directed to methods and compositions for norovirus therapeutics, such as vaccines, and diagnostics.

Abstract: The presently disclosed subject matter provides synergistic mixtures for inducing hygienic behavior in honey bees and related compositions and methods.

Abstract: The present invention provides Factor IX fusion proteins with higher specific activity and a longer useful clotting function relative to wild type or non-modified Factor IX protein.