Abstract: The present invention provides a host cell suitable for enhanced production of a protein product of choice characterised in that the host cell is genetically modified to cause over-expression of two or more helper proteins selected from a DnaJ-like protein (such as JEM1), an Hsp70 family protein (such as LHS1) and SIL1 wherein at least one of the over-expressed two or more helper proteins is selected from JEM1, LHS1 and SIL1, and wherein the DnaJ-like protein is not SCJ1.
Type:
Application
Filed:
June 22, 2006
Publication date:
January 27, 2011
Applicants:
Novozymes Delta Limited, University of Nottigham
Inventors:
Thomas Payne, Darrell Sleep, Christopher John Arthur Finnis, Leslie Robert Evans