Patents Assigned to University of South Carolina
  • Inhibitors of lysyl oxidases
    Patent number: 11712437
    Abstract: Described herein are novel compounds that block the activity of LOX family members having good IC50 values, no cellular toxicity below 10 ?M, induce sensitization of the cells to doxorubicin, strong activity in a recombinant LOX/LOXL2 activity, and a chemical structure that is drug-like and does not have a PAINS flag, as well as, methods of treatment using the compounds with respect to cancer, organ fibrosis, neurodegenerative and cardiovascular diseases.
    Type: Grant
    Filed: March 13, 2022
    Date of Patent: August 1, 2023
    Assignee: University of South Carolina
    Inventors: Ozgur Sahin, Campbell McInnes, Ozge Saatci, Chad Beneker, Abdol-Hossein Rezaeian, Metin Cetin
  • PH indicator swabs for biomonitoring and diagnostics
    Patent number: 11698344
    Abstract: Medical swabs incorporating a pH indicator in an absorbent crosslinked hydrogel matrix. The medical swabs can provide for visual monitoring of biological pH. The medical swabs can be used to monitor wounds, such as chronic wounds, burn wounds, surgical wounds, etc., as well as other biological fluids. The swabs can be used for early detection of chronic wounds and/or early detection of bacterial infections.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: July 11, 2023
    Assignee: University of South Carolina
    Inventors: Ehsan Jabbarzadeh, Sara Eslambolchimoghadam
  • In-line polymerization for customizable composite fiber manufacture in additive manufacturing
    Patent number: 11697244
    Abstract: A composite fiber for use in additive manufacturing such as fused filament fabrication is described along with methods of its construction and use. The composite fiber includes a single continuous fiber (e.g., a continuous carbon roving) and a polymer (e.g., a high glass transition polymer) in intimate contact. The composite fiber is formed through immersion of the continuous fiber in a series of two or more solutions that together include monomer(s), catalysts, or other materials for generating the polymer as the continuous fiber moves through the solutions.
    Type: Grant
    Filed: August 27, 2021
    Date of Patent: July 11, 2023
    Assignee: University of South Carolina
    Inventors: Wout De Backer, Valerie Kay, Michael Van Tooren
  • Isomer-Specific Neuroprotective Effect of Natural Resveratrol
    Publication number: 20230201133
    Abstract: Described herein are mechanistic results showing that cis- and trans-RSV have opposite effects on TyrRS-regulated neuronal DNA repair and survival, mechanistically, only cis-RSV protected neurons against stress conditions by activating TyrRS-regulated neuronal DNA repair and resilient signaling; trans-RSV, conversely, facilitated the downregulation of TyrRS resulting in the accumulation of DNA damage and subsequent neurodegeneration. Knockdown of TyrRS blunted the neuroprotective effects of cis-RSV and exacerbated the neurotoxicity by trans-RSV, providing a potential molecular basis for the controversial effects of RSV in clinical studies.
    Type: Application
    Filed: October 27, 2022
    Publication date: June 29, 2023
    Applicant: University of South Carolina
    Inventor: Sajish Mathew
  • Dually Electrically Tunable 3-D Compact RF Phase Shifter
    Publication number: 20230207998
    Abstract: An electrically tunable radio frequency phase shifter with compact 3-D structure that integrates both ferromagnetic and ferroelectric materials, and utilizes 3-D structure to increase the tuning efficiency and achieve miniaturization.
    Type: Application
    Filed: February 16, 2023
    Publication date: June 29, 2023
    Applicant: University of South Carolina
    Inventors: Tengxing Wang, Guoan Wang
  • SENSING IN TIRES FOR ROLLING RESISTANCE
    Publication number: 20230204462
    Abstract: Described herein are systems and methods for determination of rolling resistance from a sensor or sensors in a tire or tires for application in smart cars to provide feedback to interested parties, such as Departments of Transportation or tire manufacturers.
    Type: Application
    Filed: February 20, 2023
    Publication date: June 29, 2023
    Applicant: University of South Carolina
    Inventor: Paul Ziehl
  • TARGETING G3BP AGGREGATION TO PREVENT NEURODEGENERATION
    Publication number: 20230190887
    Abstract: Testing peptides in in vitro models of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Frontotemporal dementia, Amyotrophic lateral sclerosis, to evaluate systems and methods of treatment therefore.
    Type: Application
    Filed: November 18, 2022
    Publication date: June 22, 2023
    Applicants: University of South Carolina, Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Amar N. Kar, Pabitra Sahoo, Jeffery Twiss, Sean McGill, Eran Perlson, Topaz Altman, Ariel Razvan Ionescu, Tal Gradus-Pery, Amir Dori
  • Preparation of a Brain Targeted Artificial Nano-Enzyme and Application
    Publication number: 20230190791
    Abstract: Described herein are methods and systems for the preparation of a brain targeted cerium oxide nanop article (CeNP) and its application in treating central neuronal system diseases. The brain targeted CeNP (T-CeNP) can effectively pass the blood brain barrier and specifically target brain tissue and exhibit anti-inflammatory and anti-oxidant effects.
    Type: Application
    Filed: October 24, 2022
    Publication date: June 22, 2023
    Applicant: University of South Carolina
    Inventors: Peisheng Xu, Haijun Liu
  • Heat Dissipation for Millimeter-Wave Devices with Antenna Switching
    Publication number: 20230198587
    Abstract: Described herein are systems, methods and devices for implementing a temperature-aware, multi-antenna scheduler that cools mmWave devices by preventing heat buildup via switching or distributing a data stream to other redundant antennas, allowing for dissipation of heat as well as providing reliable connectivity.
    Type: Application
    Filed: February 9, 2023
    Publication date: June 22, 2023
    Applicant: University of South Carolina
    Inventors: Sanjib Sur, Moh. S. Saadat, Srihari Nelakuditi
  • Defect engineered high quality multilayer epitaxial graphene growth with thickness controllability
    Patent number: 11680333
    Abstract: Methods for forming a graphene film on a silicon carbide material are provided, along with the resulting coated materials. The method can include: heating the silicon carbide material to a growth temperature (e.g., about 1,000° C. to about 2,200° C.), and exposing the silicon carbide material to a growth atmosphere comprising a halogen species. The halogen species reacts with the silicon carbide material to remove silicon therefrom. The halogen species can comprise fluorine (e.g., SiF4, etc.), chlorine (e.g., SiCl4), or a mixture thereof.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: June 20, 2023
    Assignee: University of South Carolina
    Inventors: Tangali S. Sudarshan, Tawhid Rana, MVS Chandrashekhar
  • Vibration test-cell with axial load and in-situ microscopy
    Patent number: 11680869
    Abstract: A new vibration test-cell that allows a static load to be applied simultaneously with lateral vibration coupled with in-situ microscopy that allows for the ability to open a fatigue crack up to a desired gap, as well as generate acoustic emission (AE) from vibration excitation, micro-fracture events are captured by the AE measurement while the physical observation of the crack faying surfaces is performed in-situ with an optical microscope embedded in the test cell.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: June 20, 2023
    Assignee: University of South Carolina
    Inventors: Victor Giurgiutiu, Yeasin Bhuiyan, Matthew Droghini
  • Enzymatically cleavable self-assembled nanoparticles for morphogen delivery
    Patent number: 11672767
    Abstract: The present disclosure is directed to hybrid multifunctional macromers that can self-assemble to form nanoparticles for on-demand and targeted release of morphogens. Embodiments of the disclosure can include the hybrid multifunctional macromers and peptide sequences incorporated therein, self-assembled nanoparticles including the hybrid multifunctional macromers, methods for producing the hybrid multifunctional macromers and peptide sequences, and methods for treating a disease by the on-demand and targeted delivery of a compound using the hybrid multifunctional macromers.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: June 13, 2023
    Assignee: University of South Carolina
    Inventor: Esmaiel Jabbari
  • Measurement of fluid flow velocity with high spatial and temporal resolution
    Patent number: 11674834
    Abstract: The present disclosure provides methods and systems for flight velocimetry employing at least one bleaching laser, at least one detection laser, at least one dichroic mirror, an objective, a detection system, and a nano stage to bleach a dye to form a bleached blot in a flow pathway.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: June 13, 2023
    Assignee: University of South Carolina
    Inventor: Guiren Wang
  • Detection of Molecule-Nanoparticle Interactions with Ligand Shells
    Publication number: 20230152308
    Abstract: A quartz crystal microbalance coated with functionalized nanoparticles used to detect molecule-nanoparticle interactions to assist with characterization of difficult to predict molecule-nanoparticle interactions for novel ligand chemistries and, particularly, mixed ligand nanoparticles exhibiting different ligand morphologies, in order to quantify nanoparticle-molecule interactions independently from more complex solvation requirements.
    Type: Application
    Filed: January 13, 2023
    Publication date: May 18, 2023
    Applicant: University of South Carolina
    Inventors: Morgan Stefik, Zachary Marsh
  • Systems and methods for reliable chirp transmissions and multiplexing
    Patent number: 11652679
    Abstract: Apparatuses, systems, and methods for transmitting and multiplexing chirp signals for communications are provided. An example apparatus includes an antenna, a radio, and processing circuitry. The radio may be configured to transmit and receive wireless communications via the antenna, and the processing circuitry configured to establish a wireless communications link with a receiving communications device. The signaling transmitted by the antenna via the radio as controlled by the processing circuitry may include a plurality of sequenced chirp signals within an orthogonal frequency division multiplexing (OFDM) framework.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: May 16, 2023
    Assignee: UNIVERSITY OF SOUTH CAROLINA
    Inventors: Alphan Sahin, David Matolak, Nozhan Hosseini
  • CLOSED-LOOP SIMULTANEOUS FUNCTIONAL MAGNETIC RESONANCE IMAGING (fMRI)-ELECTROENCEPHALOGRAM (EEG)-TRANSCRANIAL MAGNETIC STIMULATION (TMS) SYSTEM
    Publication number: 20230143233
    Abstract: The present subject matter relates to techniques for systems and methods for determining alpha phase in brain of subjects undergoing depressive disorder. The disclosed system for a closed-loop operation in simultaneous functional magnetic resonance imaging (fMRI)-electroencephalogram (EEG)-transcranial magnetic stimulation (TMS), can include a processor that be configured to receive and process a functional magnetic resonance imaging (fMRI) data and/or an extracranial electroencephalogram (EEG) data and/or transcranial magnetic stimulation (TMS) pulse simultaneously.
    Type: Application
    Filed: November 10, 2022
    Publication date: May 11, 2023
    Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, MEDICAL UNIVERSITY OF SOUTH CAROLINA
    Inventors: Paul Sajda, Truman R. Brown, Mark S. George, Robin Goldman, Josef Faller, Jaycee Doose, James McIntosh, Joshua B. Teves, Yida Lin, Golbarg T. Saber, Aidan Blankenship, Spiro P. Pantazatos, Xiaoxiao Sun
  • Identifying structural defect geometric features from acoustic emission waveforms
    Patent number: 11639915
    Abstract: The current disclosure determines if structural faults exist and extracts geometric features of the structural faults from acoustic emission waveforms, such as crack length and orientation, and can evaluate the structural faults online, during normal operation conditions.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: May 2, 2023
    Assignee: University of South Carolina
    Inventors: Victor Giurgiutiu, Jingjing Bao, Banibrata Poddar, Md Yeasin Bhuiyan
  • Regenerative Tissue-Mimetic Multilayer Fused Microgel-Cell Construct
    Publication number: 20230122977
    Abstract: Described herein are regenerative approaches with tunable cell-cell and cell-matrix interactions to enhance the ability to regenerate multiple zones within a construct with each zone possessing a unique, optimum, level of cell-cell and cell-matrix interaction.
    Type: Application
    Filed: March 10, 2022
    Publication date: April 20, 2023
    Applicant: University of South Carolina
    Inventor: Esmaiel Jabbari
  • Anti-CCL8 antibodies and uses thereof
    Patent number: 11629186
    Abstract: Anti-CCL8 antibodies and antigen binding fragments thereof are described. Antibodies and fragments thereof can be used for prevention of migration of breast cancer cells. Methods include delivery of an anti-CCL8 antibody or an antigen binding fragment thereof to an area including the breast cancer cells, e.g., delivery to a subject in need thereof in an effective amount.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: April 18, 2023
    Assignee: University of South Carolina
    Inventors: Hippokratis Kiaris, Eleni Farmaki, Ioulia Chatzistamou, Vimala Kaza
  • Co-electroless deposition methods for formation of methanol fuel cell catalysts
    Patent number: 11631876
    Abstract: The present disclosure is directed to compositions and structures of supported metal catalysts for use in applications such as direct methanol fuel cells. Generally, implementations include supported metal catalysts that include Pt active sites that have been modified by addition or co-localization of a second metal such as Cu, Co, Ni, and/or other base metals to lower the inhibiting effect of strongly-adsorbed CO, an intermediate of methanol oxidation. An example aspect of the present disclosure includes catalyst compositions where the exterior metal sites in the supported catalyst include at least two metals: Pt and a competitive binder (e.g., a second metal).
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: April 18, 2023
    Assignee: University of South Carolina
    Inventors: John R. Monnier, Gregory L. Tate, Wen Xiong, Benjamin H. Meekins