Patents Assigned to University of Tsukuba
  • Publication number: 20220336117
    Abstract: As a sintered body for a radiation shielding material, which can effectively shield mainly low-energy-level neutrons, that is, thermal neutrons and lower, slow neutrons, and has excellent physical properties such as bending strength and Vickers hardness, leading to high machining strength, a sintered body for a radiation shielding material comprising LiF ranging between 99 wt. % to 5 wt. %, and one or more fluorides selected from among MgF2, CaF2, AlF3, KF, NaF, and/or YF3 ranging between 1 wt. % to 95 wt. %, having physical properties of a relative density of 92% or more, a bending strength of 50 MPa or more, and a Vickers hardness of 100 or more, is provided.
    Type: Application
    Filed: August 20, 2021
    Publication date: October 20, 2022
    Applicants: UNIVERSITY OF TSUKUBA, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, DAICO MFG CO., LTD.
    Inventors: Hiroaki KUMADA, Naoyuki KITAMURA, Tetsuyuki NAKAMURA, Takeshi IKEDA
  • Publication number: 20220332876
    Abstract: [Object] To provide a derivative of a short chain fatty acid that can exhibit physiological functions inherent in the short chain fatty acid. [Solution] Provided is a block or graft copolymer including a hydrophobic segment of a repeat unit containing a short chain fatty acid ester that is hydrolyzable by esterase in vivo and a hydrophilic segment including a poly(ethylene glycol) chain. These copolymers are effective in the treatment or therapeutic treatment of various diseases or disorders, including cancer.
    Type: Application
    Filed: July 30, 2020
    Publication date: October 20, 2022
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Yukio NAGASAKI, Babita SHASHNI, Binh Long VONG, Ryusaku OKADA, Yuya TAJIKA, Yaroslav LEE
  • Publication number: 20220323761
    Abstract: A method for inducing a hibernation-like state and a device for the same is described. The method is a chemical and physical method for reducing, in a subject, a theoretical set-point temperature of a body temperature and/or a feedback gain of heat production, or for inducing a hibernation-like state in the subject, the method including applying an excitatory stimulus to pyroglutamylated RFamide peptide (QRFP)-producing neurons. A device used to implement the method is also described.
    Type: Application
    Filed: September 30, 2020
    Publication date: October 13, 2022
    Applicant: University of Tsukuba
    Inventors: Takeshi SAKURAI, Toru TAKAHASHI, Genshiro SUNAGAWA
  • Publication number: 20220315427
    Abstract: A carbon nanotube assembled wire includes a plurality of carbon nanotubes, wherein in a Raman spectrum of the carbon nanotube assembled wire, a ratio IB/IA of an integrated intensity IA in a range of a Raman shift of 120 cm?1 or more and 210 cm?1 or less and an integrated intensity IB in a range of a Raman shift of more than 210 cm?1 and 280 cm?1 or less is 0.1 or more.
    Type: Application
    Filed: August 28, 2020
    Publication date: October 6, 2022
    Applicants: SUMITOMO ELECTRIC INDUSTRIES, LTD., UNIVERSITY OF TSUKUBA
    Inventors: Takeshi HIKATA, Toshihiko FUJIMORI, Soichiro OKUBO, Jun OTSUKA, Jun-ichi FUJITA
  • Patent number: 11457878
    Abstract: An image generation method of an interior CT includes the following steps: a step for obtaining interior CT projection data by measuring quantum beams passing through a region of interest (ROI) in an inside of photographing object in a geometrical system for CT measurement; a step for obtaining partial entire projection data by measuring quantum beams passing through an entire of said photographing object from a segment in an outside of said photographing object in said geometrical system for CT measurement; and a processing step for exactly reconstructing said ROI upon basis of said interior CT projection data obtained and said partial entire projection data.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: October 4, 2022
    Assignee: UNIVERSITY OF TSUKUBA
    Inventor: Hiroyuki Kudo
  • Publication number: 20220298499
    Abstract: An artificial gene has a 15N abundance exceeding a natural abundance in bases of at least a portion of DNA. A method for mutating a gene includes a first step of producing a state in which 15N is unevenly distributed into a prescribed DNA in a living cell; and a second step of irradiation with a proton beam at an energy at which the 15N produces a resonant nuclear reaction.
    Type: Application
    Filed: August 7, 2020
    Publication date: September 22, 2022
    Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, UNIVERSITY OF TSUKUBA
    Inventors: Yasushi IWATA, Kanako TOMITA, Iwane SUZUKI, Ryo MORIOKA, Tianjing YANG
  • Publication number: 20220298524
    Abstract: The present application provides: a fruit-bearing plant exhibiting parthenocarpy or a potion thereof including a mutation in a Solyc10g038170 gene or ortholog thereof, the mutation causing deficiency or reduction in expression of a protein encoded by the Solyc10g038170 gene or ortholog thereof; a method for producing a parthenocarpic fruit-bearing plant or a potion thereof; and a method for selecting a parthenocarpic fruit-bearing plant or a potion thereof.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 22, 2022
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Tohru ARIIZUMI, Hiroshi EZURA, Keiichiro HARADA, Yoshihito SHINOZAKI, Ryoichi YANO, U RIKU
  • Publication number: 20220256847
    Abstract: An inhibitor of cell death induced by transient protein expression in a plant, the inhibitor including, as an active ingredient, ascorbic acid or a derivative thereof, a salt thereof, or a solvate thereof, can advantageously inhibit cell death induced by transient protein expression in a plant.
    Type: Application
    Filed: July 29, 2020
    Publication date: August 18, 2022
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Kenji MIURA, Fuminori TSURUTA
  • Publication number: 20220241308
    Abstract: Provided is a neuronal function modulating agent effective for neuronal cell protection and exerts a neuronal function modulating effect through neuronal cell protection. The disclosed neuronal function modulating agent comprises malvidin-3,5-diglucoside as an active ingredient, the disclosed pharmaceutical composition comprises the neuronal function modulating agent, and the disclosed food composition comprises the neuronal function modulating agent.
    Type: Application
    Filed: May 22, 2020
    Publication date: August 4, 2022
    Applicants: University of Tsukuba, National Institute of Advanced Industrial Science and Technology, ZEON CORPORATION
    Inventors: Hiroko ISODA, Kazunori SASAKI, Kazuhiko SATO, Masumi ASAKAWA, Kenichi TOMINAGA, Hiroshi FUJISAWA, Masami KOSHIYAMA
  • Publication number: 20220236275
    Abstract: The present invention relates to a method for analyzing a biological sample obtained from a subject, comprising analyzing components contained in a biological sample by an assay using a first molecule selected from the group consisting of a molecule binding to a sugar chain bindable with BC2LCN, a molecule binding to SerpinA3, and a molecule binding to Gal3BP, and a second molecule that is BC2LCN.
    Type: Application
    Filed: April 11, 2022
    Publication date: July 28, 2022
    Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, UNIVERSITY OF TSUKUBA
    Inventors: Hiroaki TATENO, Tatsuya ODA, Osamu SHIMOMURA
  • Publication number: 20220233626
    Abstract: Provided is a grape pericarp extract that exhibits neuronal function modulating effects. The grape pericarp extract comprises 15 mg/g or more of malvidin-3,5-diglucoside in dry mass.
    Type: Application
    Filed: May 22, 2020
    Publication date: July 28, 2022
    Applicants: University of Tsukuba, National Institute of Advanced Industrial Science and Technology, ZEON CORPORATION
    Inventors: Hiroko ISODA, Kazunori SASAKI, Kazuhiko SATO, Masumi ASAKAWA, Kenichi TOMINAGA, Hiroshi FUJISAWA, Masami KOSHIYAMA
  • Publication number: 20220226479
    Abstract: There is provided technology for promoting permeation of a substance into a cell layer. Provided is a cell layer permeation promoter comprising a compound represented by general formula (1). Also provided is a composition for facilitating drug absorption that contains the cell layer permeation promoter, said composition being for facilitating absorption of a drug into a living body. Also provided is a pharmaceutical composition that contains the cell layer permeation promoter and furthermore contains a drug to be absorbed into a living body.
    Type: Application
    Filed: March 19, 2020
    Publication date: July 21, 2022
    Applicants: University of Tsukuba, Tokyo University of Pharmacy and Life Sciences
    Inventors: Takeo USUI, Yoko NAGUMO, Minagi MUKAIYAMA, Yoshio HAYASHI, Atsuhiko TANIGUCHI, Chihiro UCHIYAMA
  • Publication number: 20220211764
    Abstract: The present disclosure relates to a neural cell population, a neural cell-containing preparation, and a method for producing the population and preparation. More particularly, the present invention relates to a neural cell population derived from intraoral mesenchymal cells, wherein a proportion of normal diploid cells is 80% or more, a preparation containing the neural cell population, and a method for producing the population and the preparation.
    Type: Application
    Filed: May 14, 2020
    Publication date: July 7, 2022
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Aiki MARUSHIMA, Akira MATSUMURA, Hiroki BUKAWA, Masao KODA, Hiroshi ISHIKAWA, Akihiro OHYAMA, Junko TOYOMURA, Yuji MATSUMARU, Hideaki MATSUMURA, Miho WATANABE
  • Patent number: 11344229
    Abstract: A wearable gait detection device, a walking ability improvement system and a wearable gait detection system detect manifestation in a brain based on the wearer's gait and preventive measures. A load measurement part measures a load of a sole of the wearer's feet, a foot movement detection part at the shoes detects acceleration and/or angular velocity during feet movement, a centroid position calculation part calculates a centroid position of the feet based on changes in measured load, a movement locus calculation part calculates a movement locus of the feet based on acceleration and/or angular velocity detected by the foot movement detection part, a manifestation recognition part recognizes manifestation in the brain according to a specificity of centroid fluctuation of the feet based on the calculated centroid position and movement locus of the feet, and a sensory output part feeds back a sensation to the wearer based on a recognition result.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: May 31, 2022
    Assignees: CYBERDYNE INC., UNIVERSITY OF TSUKUBA
    Inventor: Yoshiyuki Sankai
  • Publication number: 20220153806
    Abstract: The present invention provides a composition and method for treating an allergic disease. The composition comprises a ligand for asialoglycoprotein receptor 1 (Asgr1). The allergic disease may be atopic dermatitis, allergic rhinitis, urticaria, allergic asthma, allergic conjunctivitis, allergic gastrointestinal inflammation, or anaphylactic shock. The allergic disease may be caused by house dust mites. The present invention also provides a method for determining if a test compound activates human Asgr1.
    Type: Application
    Filed: February 28, 2020
    Publication date: May 19, 2022
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Akira SHIBUYA, Kazumasa KANEMARU
  • Publication number: 20220153585
    Abstract: A method for manufacturing a carbon nanotube includes: a mist generating step of generating a mist including a catalyst particle and a liquid carbon source; and a growing step of growing a carbon nanotube from the catalyst particle by heating the mist.
    Type: Application
    Filed: February 18, 2020
    Publication date: May 19, 2022
    Applicants: SUMITOMO ELECTRIC INDUSTRIES, LTD., UNIVERSITY OF TSUKUBA
    Inventors: Takeshi HIKATA, Toshihiko FUJIMORI, Soichiro OKUBO, Jun OTSUKA, Jun-ichi FUJITA
  • Publication number: 20220156932
    Abstract: Provided are a skin disease analysis program, a skin disease analysis method, a skin disease analyzer, and a skin disease analysis system, which can analyze skin disease more accurately.
    Type: Application
    Filed: March 26, 2020
    Publication date: May 19, 2022
    Applicants: University of Tsukuba, SOINN Inc., Life Science Institute, Inc.
    Inventors: Yasuhiro FUJISAWA, Kodai IWASHITA, Mitsuyoshi ISHIDA
  • Patent number: 11335083
    Abstract: Provided are an object identification device and an object identification method in which objects can be easily identified. The object identification device is provided with a pixel group extraction unit which scans, in units of the image area, an X-ray transferred image obtained from an imaging unit which performs X-ray imaging to an item to be inspected that is supplied, and extracts a plurality of pixel groups including characteristics of a shape of at least a part of the item to be inspected, and a determination unit which determines, with regard to the plurality of pixel groups extracted by the pixel group extraction unit, whether the item to be inspected corresponds to the object by executing all of the series of mappings related to an angle of an n direction by using each of the weight parameters based on the data group read from the memory unit.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: May 17, 2022
    Assignees: CYBERDYNE INC., University of Tsukuba
    Inventor: Yoshiyuki Sankai
  • Patent number: 11328434
    Abstract: An object tracking device includes a superimposed image creation unit configured to create a plurality of superimposed images in which each of a plurality of non-tracking object images which do not include a tracking object image feature is superimposed on a tracking object section image which includes a tracking object image feature; a discriminator creation unit configured to learn at least one of an image feature and position information of the tracking object, based on the plurality of superimposed images to create a discriminator; and a tracking object specifying unit configured to specify at least one of the image feature and the position information of the tracking object in a tracked image including the respective image features of the tracking object and an obstacle, based on the discriminator and the tracked image.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: May 10, 2022
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Toshiyuki Terunuma, Takeji Sakae
  • Publication number: 20220125752
    Abstract: Incorporation of L-DOPA into a carrier in a form of a block copolymer (PEG-b-poly(3,4-hydroxy-protected L-DOPA)) significantly improves the retention of the agent in the blood, thus mitigating a shortcoming associated with L-DOPA in treating Parkinson's disease.
    Type: Application
    Filed: February 6, 2020
    Publication date: April 28, 2022
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Yukio NAGASAKI, Yuna SATO, Long Binh VONG, Pennapa CHONPATHOMPIKUNLERT, Pilaiwanwadee HUTAMEKALIN, Reita TAKAHASHI