Abstract: Technology is described for a relative timed clock gated cell. In one example, the relative timed clock gated cell includes a trigger latch and a data clock latch. The trigger latch includes a clock input coupled to a trigger line for transmitting a trigger signal. The trigger latch is configured to generate a data clock signal on an output. The trigger signal is based on a clock signal. The data clock latch includes a clock input coupled to the output of the trigger latch that latches a data input of the data clock latch based on the data clock signal. Various other computing circuitries and methods are also disclosed.

Abstract: Disclosed herein are methods and compositions for determining the copy number of a first target nucleic acid as compared to the copy number of a second target nucleic acid in a single well with a single detection label. For example, disclosed herein are methods and compositions for determining the copy number of a first target nucleic acid as compared to the copy number of a second target nucleic acid by a monochrome multiplex quantitative PCR (MMQPCR) in a single well with a single detection label.

Abstract: Systems and methods which utilize spread spectrum sensing on live circuits to obtain information regarding a circuit under test are provided. In some embodiments S/SSTDR testing may be utilized to obtain R, L, C and Z measurements from circuit components. In yet further embodiments, these measurements may be utilized to monitor the output of sensors on a circuit.

Abstract: A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber for culturing the captured stem cells.

Abstract: A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory (14) that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber (39) for culturing the captured stem cells.

Abstract: Described herein are labeled proteins and methods of use thereof for identifying the position of multiple disulfide bridges present in the peptide. The methods combine the use of diselenide bridges and NMR-based mapping of the disulfide bridges. Also described herein are labeled proteins described above that contain fluorous bridges and spacers that facilitate oxidative folding of the protein. The resulting biorthogonal oxidation strategy for studying disulfide-rich peptides both improves oxidative folding and provides simultaneous determination of the disulfide crosslink connectivity in the peptide. The methods permit routine and facile production of disulfide-rich peptides.

Abstract: Disclosed herein are methods and compositions for determining the copy number of a first target nucleic acid as compared to the copy number of a second target nucleic acid in a single well with a single detection label. For example, disclosed herein are methods and compositions for determining the copy number of a first target nucleic acid as compared to the copy number of a second target nucleic acid by a monochrome multiplex quantitative PCR (MMQPCR) in a single well with a single detection label.

Abstract: Disclosed are compounds having the structure: wherein R1a and R1b are independently H, alkyl, F, or fluoroalkyl; wherein R2a, R2b, R2a?, and R2b? are independently H, alkyl, F, fluoroalkyl, aryl, or alkenyl; wherein R3 is OH, alkoxyl, NH2, alkylamino, or dialkylamino; wherein R4a and R4b are independently H, alkyl, acyl, or alkyloxycarbonyl; wherein R11, R12, R13, R21, R22, and R23 are independently H, alkyl, F, or fluoroalkyl; and wherein C0, C1, C2 and C2? are independently chiral or achiral. Also disclosed are processes for making a fluorinated ?-amino acid comprising the steps of: providing a diol; treating the diol with a thionyl halide with oxidative workup; reacting the product with an azide salt to yield an azido group; oxidizing the product to yield a carboxyl group; and reducing the azido group to yield an amino group.

Abstract: Composite wall panels are a viable method of quick and inexpensive building. Providing a composite wall panel with increased shear resistance and axial load capacity is extremely desirable. A fiber reinforced polymer (FRP) cage incorporated into composite wall panels which forms a wall panel with these desirable characteristics and a method of forming such a composite wall panel is disclosed and described. The FRP cages can include FRP shells or sleeves which include two or more bars secured thereto. One or more FRP cages can be incorporated into a composite wall panel where a portion of the FRP shell is imbedded in each of two concrete layers with an insulation layer therebetween. The resulting FRP reinforced composite wall panel has improved shear resistance and axial compressive strength which can allow for use in load bearing applications and generally improved properties such as thermal insulation.