Patents Assigned to USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I.
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Publication number: 20210283568Abstract: The present invention relates to a process for ion irradiation of a particulate substrate containing the steps of embedding particulate substrate in a solid matrix having 10B atoms, and exposing the matrix obtained in the previous step to a neutron flux to give irradiated particulate substrate. The process is extremely effective and amenable to large scale and is particularly suitable for producing irradiated nanodiamonds and irradiated SiC particles.Type: ApplicationFiled: July 8, 2019Publication date: September 16, 2021Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I., USTAV MAKROMOLEKULARNI CHEMIE AV CR, V. V. I.Inventors: Petr CIGLER, Jan HAVLIK, Martin HRUBY, Jan KUCKA
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Patent number: 10626209Abstract: The present invention relates to the preparation and use of copolymers composed of N-(2-hydroxypropyl) methacrylamide (HPMAA) and carboxybetaine methacrylamide (CBMAA). The invention further describes polymer brushes having structure I S—R-polymer??(I) wherein S is a substrate; R is a residue of a polymerization initiator or a RAFT agent bound to the substrate; and “polymer” is the copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide Furthermore, production of these polymer brushes, containing random or block copolymers grafted to or from a substrate is described. The copolymer brushes are suitable for protecting substrates from deposition and/or adhesion of biological substances, and/or against thrombus formation. The brushes functionalized by covalent attachment of bioactive substances to CBMAA monomer units are particularly suitable for specific interaction with target biological substances which is not affected by nonspecific deposition of non-target compounds.Type: GrantFiled: May 5, 2016Date of Patent: April 21, 2020Assignees: USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., USTAV FOTONIKY A ELEKTRONIKY AV CR, V.V.I.Inventors: Cesar Rodriguez-Emmenegger, Frantisek Surman, Eduard Brynda, Tomas Riedel, Milan Houska, Hana Lisalova, Jiri Homola
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Patent number: 10302632Abstract: A macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells.Type: GrantFiled: September 12, 2018Date of Patent: May 28, 2019Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., UNIVERZITA KARLOVA V PRAZE, PRIRODOVEDECKA FAKULTAInventors: Pavel Sacha, Jan Konvalinka, Jiri Schimer, Tomas Knedlik, Vaclav Navratil, Jan Tykvart, Frantisek Sedlak, Pavel Majer, Petr Cigler, Vladimir Subr, Karel Ulbrich, Jiri Strohalm
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Publication number: 20190033300Abstract: A macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells.Type: ApplicationFiled: September 12, 2018Publication date: January 31, 2019Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., UNIVERZITA KARLOVA V PRAZE, PRIRODOVEDECKA FAKULTAInventors: PAVEL SACHA, JAN KONVALINKA, JIRI SCHIMER, TOMAS KNEDLIK, VACLAV NAVRATIL, JAN TYKVART, FRANTISEK SEDLAK, PAVEL MAJER, PETR CIGLER, VLADIMIR SUBR, KAREL ULBRICH, JIRI STROHALM
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Publication number: 20180346634Abstract: The present invention relates to the preparation and use of copolymers composed of N-(2-hydroxypropyl) methacrylamide (HPMAA) and carboxybetaine methacrylamide (CBMAA). The invention further describes polymer brushes having structure I S-R-polymer ??(I) wherein S is a substrate; R is a residue of a polymerization initiator or a RAFT agent bound to the substrate; and “polymer” is the copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide Furthermore, production of these polymer brushes, containing random or block copolymers grafted to or from a substrate is described. The copolymer brushes are suitable for protecting substrates from deposition and/or adhesion of biological substances, and/or against thrombus formation. The brushes functionalized by covalent attachment of bioactive substances to CBMAA monomer units are particularly suitable for specific interaction with target biological substances which is not affected by nonspecific deposition of non-target compounds.Type: ApplicationFiled: May 5, 2016Publication date: December 6, 2018Applicants: USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., USTAV FOTONIKY A ELEKTRONIKY AV CR, V.V.I.Inventors: CESAR RODRIGUEZ-EMMENEGGER, Frantisek SURMAN, Eduard BRYNDA, Tomas RIEDEL, Milan HOUSKA, Hana LISALOVA, Jiri HOMOLA
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Patent number: 10114014Abstract: Synthetic macromolecular conjugate for selective interaction with proteins has a synthetic copolymer, and at least one binding group and at least one further group selected from an affinity tag and an imaging probe, and at least one binding group and at least one further group being bound via covalent bond to the synthetic copolymer. The macromolecular conjugate is suitable in particular for identification, visualization, quantification or isolation of proteins and/or cells.Type: GrantFiled: January 13, 2016Date of Patent: October 30, 2018Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., UNIVERZITA KARLOVAInventors: Pavel Sacha, Jan Konvalinka, Jiri Schimer, Tomas Knedlik, Vladimir Subr, Karel Ulbrich, Jiri Strohalm
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Publication number: 20180052152Abstract: Macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe, and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells. The targeting ligand may be attached to the synthetic copolymer via a flexible linker.Type: ApplicationFiled: January 13, 2016Publication date: February 22, 2018Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., UNIVERZITA KARLOVA V PRAZE, PRIRODOVEDECKA FAKULTAInventors: Pavel Sacha, Jan KONVALINKA, Jiri SCHIMER, Tomas KNEDLIK, Vaclav NAVRATIL, Jan TYKVART, Frantisek SEDLAK, Pavel MAJER, Petr CIGLER, Vladimir SUBR, Karel ULBRICH, Jiri STROHALM
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Publication number: 20180011085Abstract: Synthetic macromolecular conjugate for selective interaction with proteins has a synthetic copolymer, and at least one binding group and at least one further group selected from an affinity tag and an imaging probe, and at least one binding group and at least one further group being bound via covalent bond to the synthetic copolymer. The macromolecular conjugate is suitable in particular for identification, visualization, quantification or isolation of proteins and/or cells.Type: ApplicationFiled: January 13, 2016Publication date: January 11, 2018Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., UNIVERZITA KARLOVAInventors: Pavel Sacha, Jan KONVALINKA, Jiri SCHIMER, Tomas KNEDLIK, Vladimir SUBR, Karel ULBRICH, Jiri STROHALM
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Patent number: 9173949Abstract: The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.Type: GrantFiled: December 14, 2010Date of Patent: November 3, 2015Assignees: USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I., MIKROBIOLOGICKY USTAV AV CR, V.V.I.Inventors: Tomas Etrych, Petr Chytil, Jiri Strohalm, Karel Ulbrich, Blanka Rihova