Patents Assigned to USV Pharmaceutical Corp.
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Patent number: 4758586Abstract: Indolyl dieneoic acids and esters are disclosed possessing valuable pharmaceutical activity, particularly as lipoxygenase inhibitors with anti-inflammatory and anti-allergic properties.Type: GrantFiled: January 21, 1986Date of Patent: July 19, 1988Assignee: USV Pharmaceutical Corp.Inventors: Wan-kit Chan, Thomas D. Lee, Fu-chih Huang
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Patent number: 4666909Abstract: Compounds of the formula: ##STR1## wherein, R is H, alkyl, cycloalkyl, aryl or heteroaryl;R.sub.1 is H, alkyl, cycloalkyl, aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aryl, halo, OR.sup.2, SR.sup.2, NR.sub.2, CF.sub.3, NO.sub.2, CN, COOR.sup.2, CHO, SO.sub.3 H or SO.sub.2 NH.sub.2,whereinR.sup.2 is H, methyl, ethyl or propyl;Y is ##STR2## Z is O, S, NH or CH.sub.2 ; X is ##STR3## wherein R.sup.2 is H, methyl, ethyl or propyl;n is 1-10, and pharmaceutically acceptable salts thereof have antiallergy and antiinflammatory activity.Type: GrantFiled: September 16, 1985Date of Patent: May 19, 1987Assignee: USV Pharmaceutical Corp.Inventors: Howard Jones, Ernest Magnien, John H. Musser, Mujahid L. Shaikh
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Patent number: 4656281Abstract: The quinoline compounds being of the formula: ##STR1## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl,Y is nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl aralkyl, acyl, aminoalkyl, or carboxyalkyl,Z is nitrogen,X is cyano, carbalkoxyl, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, andm is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or intermediates in the preparation of compounds useful for treating asthma.Type: GrantFiled: May 8, 1985Date of Patent: April 7, 1987Assignee: USV Pharmaceutical Corp.Inventors: John H. Musser, Richard E. Brown
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Patent number: 4632929Abstract: Compounds of the formulae: ##STR1## wherein, Z and Y are each alkylene or oxy-alkylene containing one to about five carbon atoms in the principal chain or said alkylene substituted with OH, alkanoyloxy, alkoxy, mercapto or alkylmercapto;each of R.sub.1, R.sub.2 and R.sub.3 is independently H, alkyl, aryl, halo, alkoxy, alkenyloxy, alkylsulfinyl, alkylsulfonyl, alkylmercapto, cyano, carboxy, carbalkoxy, carboxamido, sulfamoyl, trifluoromethyl, hydroxy, hydroxyalkyl, acyloxy, alkylamino, sulfonylamino, or acylamino; or R.sub.1 and R.sub.2, when taken together, form a methylenedioxy or --O--CO--O--;Ar is heteroaryl, cycloalkyl or ##STR2## wherein, R.sub.1, R.sub.2 and R.sub.3 are as hereindescribed; and R is H, alkyl, cycloalkyl, aryl, aralkyl, alkenyl, alkynyl, carboalkoxy, or CONR.sub.4 R.sub.5 wherein each of R.sub.4 and R.sub.5 is H or alkyl; wherein the total number of carbon atoms in each hydrocarbyl group is up to 10; and ##STR3## wherein, each of R.sub.1 and R.sub.Type: GrantFiled: September 23, 1985Date of Patent: December 30, 1986Assignee: USV Pharmaceutical Corp.Inventors: John T. Suh, Rack H. Chung, deceased, Nai-Yi Wang, Jeffrey N. Barton
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Patent number: 4631287Abstract: The present invention is concerned with the therapeutic composition comprising as an active ingredient a compound of the formula:(R.sub.1)(R.sub.2)Ar--Z--M--Ar.sub.1 (R.sub.3)(R.sub.4) Iand salts thereof;whereinAr and Ar.sub.1 are independently phenyl, naphthyl or a nitrogen, oxygen, or sulfur heterocyclic ring;Z is an alkylene chain containing from 1 to 5 carbon atoms in the principal chain and up to a total of 10 carbon atoms;M is oxygen, sulfur, or NR.sub.5 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently H, lower alkyl, lower alkoxy, hydroxy, halo, trihalomethyl, hydroxy lower alkyl, carboxy, formyl, aryl, aryloxy, benzyloxy, lower alkanoyl, carboxy lower alkoxy, nitro, amino, lower alkylamino, dilower alkylamino, cyano, lower alkanoyloxy, carbamoyl, lower alkoxy-alkoxy, carbo-lower-alkoxy-alkoxy, or tetrahydropyranylmethyl; andR.sub.5 is hydrogen or lower alkyl.Type: GrantFiled: April 16, 1985Date of Patent: December 23, 1986Assignee: USV Pharmaceutical Corp.Inventors: Utpal R. Chakraborty, Raymond D. Youssefyeh
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Patent number: 4625034Abstract: This invention relates to novel lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic activities. The present new compounds are di- and tetra-hydroquinoline or di- and tetra-hydronapthalene derivatives, more particularly, 1,2-, 1,4-, 5,6-, or 7,8-dihydro; 1,2,3,4-tetrahydro-; 5,8-dihydro-; or 5,6,7,8-tetrahydroquinoline or napthalene derivatives of a compound of the formula: ##STR1## and oxides, quaternary ammonium salts and acid salts thereof; wherein A is CH or N;Z is an alkylene chain containing up to 10 carbon atoms in the principal chain and a total of up to 12 carbon atoms and the said alkylene chain may be attached to the phenyl group through an oxygen atom;R is the substituent OR.sub.6 attached to one of the carbon atoms of Z in which R.sub.6 is H, lower alkyl or phenyl;X is --O(CHR.sub.5).sub.m --, alkylene of up to 2 carbon atoms in the principal chain and up to a total of 4 carbon atoms or ##STR2## wherein R.sub.5 is H or CH.sub.3 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.Type: GrantFiled: February 4, 1985Date of Patent: November 25, 1986Assignee: USV Pharmaceutical Corp.Inventors: Edward S. Neiss, Rohit M. Desai, Raymond D. Youssefyeh
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Patent number: 4623716Abstract: Peptides, such as calcitonin, having two cysteine residues connected by a disulfide bond are prepared by a process which includes the step of cyclizing the cysteines at a pH of 8.5 to 9.0, and a concentration of 0.4 to 1.8 mg of peptide per ml of solution. These novel conditions produce rapid cyclization with an unforeseen improvement in yield.Type: GrantFiled: November 1, 1984Date of Patent: November 18, 1986Assignee: USV Pharmaceutical Corp.Inventors: David Stevenson, Mohammad A. Islam
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Patent number: 4619945Abstract: Polyene compounds represented by the formula ##STR1## where R is H or lower alkyl of from 1 to 5 carbon atoms;R.sub.1 is H, lower alkyl of from 1 to 8 carbon atoms or aralkyl; andR.sub.2 is (CH.sub.2).sub.n CH.sub.2 OH, CHO or CO.sub.2 R; wherein n is 1 or 2.The foregoing compounds have been found active in regulating the formation of lipoxygenase and as such possess therapeutic value in the treatment of inflammatory conditions and allergic responses.Type: GrantFiled: October 9, 1985Date of Patent: October 28, 1986Assignee: USV Pharmaceutical CorpInventors: Bernard Loev, Wan-Kit Chan
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Patent number: 4620010Abstract: A process is provided to a unique preparation of carboalkoxy substituted or unsubstituted benzoxazole compounds from an amino-phenol compound.Type: GrantFiled: March 29, 1984Date of Patent: October 28, 1986Assignee: USV Pharmaceutical Corp.Inventors: Shou-Nan Ueng, Frederick A. Golec, Jr.
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Patent number: 4614747Abstract: This invention relates to novel compounds having pharmaceutical activity and having the general structure ##STR1## wherein the Z, R.sub.1, R.sub.2, R.sub.3, R.sub.4, n and m are defined within.Type: GrantFiled: November 29, 1984Date of Patent: September 30, 1986Assignee: USV Pharmaceutical Corp.Inventors: Bernard Loev, Howard Jones, Wan-kit Chan
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Patent number: 4605675Abstract: Polyene compounds represented by the formula ##STR1## in which R is H or an alkyl group of from 1 to 5 carbon atoms, R.sub.1 is H, lower alkyl of from 1 to 8 carbon atoms or aralkyl, and the pharmaceutically acceptable salts thereof.The foregoing compounds have been found active in regulating phospholipases and as such possess therapeutic value in the treatment of inflammatory conditions.Type: GrantFiled: October 16, 1985Date of Patent: August 12, 1986Assignee: USV Pharmaceutical Corp.Inventors: Bernard Loev, Wan-Kit Chan
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Patent number: 4596791Abstract: Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.Type: GrantFiled: January 10, 1985Date of Patent: June 24, 1986Assignee: USV Pharmaceutical Corp.Inventors: John J. Piwinski, John T. Suh, Paul Menard, Howard Jones, Edward S. Neiss
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Patent number: 4595696Abstract: Polyene compounds represented by the general formula ##STR1## where R.dbd.H or lower alkyl group of from 1 to 5 carbon atoms ##STR2## n is 0-1 x is O or S; andR.sub.1 =an alkyl group of from 1 to 5 carbon atoms; and the pharmaceutically acceptable salts thereof.and the pharmaceutically acceptable salts thereof.The foregoing compounds have been found to be effective in regulating the formation of lipoxygenese and as such possess therapeutic value in the treatment of inflammatory conditions and allergic responses.Type: GrantFiled: September 13, 1985Date of Patent: June 17, 1986Assignee: USV Pharmaceutical Corp.Inventors: Bernard Loev, Wan-Kit Chan
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Patent number: 4588734Abstract: Compounds of the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl,n is an integer from 0 to 4 inclusive,M is heterocyclic or heterocyclic alkyl,Y is hydroxy, alkoxy, amino, or substituted amino, amino-alkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is hydrogen, alkanoyl, carboxylalkanoyl, hydroxyalkanoyl, amino-alkanoyl, cyano, amidino, carbalkoxy, ZS, or ##STR2## wherein Z is hydrogen, alkyl, hydroxyalkyl, aminoalkyl or the radical ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n, M and Y are as described above; and where Y is hydroxy their nontoxic, pharmaceutically acceptable alkali metal, alkaline earth metal, and amine salts.These compounds possess antihypertensive and angiotensin converting enzyme inhibitory activity.Type: GrantFiled: November 19, 1984Date of Patent: May 13, 1986Assignee: USV Pharmaceutical Corp.Inventors: John T. Suh, Jerry W. Skiles, Bruce E. Williams, Alfred Schwab
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Patent number: 4588737Abstract: Compounds possessing valuable therapeutic activity particularly as lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties, of the formula: ##STR1## wherein Z is an unsubstituted normal alkylene chain of up to 8 carbon atoms or a substituted normal alkylene chain in which the substituent is lower alkyl, phenyl or benzyl containing up to 8 carbon atoms in the normal chain and up to a total of about 12 carbon atoms;X=O to S;n=0 or 1; andeach R is H, lower alkyl or lower alkanoyl; and salts thereof, especially pharmaceutically-acceptable salts.Type: GrantFiled: December 20, 1984Date of Patent: May 13, 1986Assignee: USV Pharmaceutical Corp.Inventor: Fu-chih Huang
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Patent number: 4585758Abstract: Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.Type: GrantFiled: January 10, 1985Date of Patent: April 29, 1986Assignee: USV Pharmaceutical Corp.Inventors: Fu-chih Huang, John T. Suh, Jerry W. Skiles
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Patent number: 4579865Abstract: Compounds of the structure; ##STR1## and pharmaceutically acceptable salts thereof, wherein:R.sub.1 is H, alkyl, alkoxy, carboxyl, alkylcarboxy, trifluoromethyl, halogen, nitro or hydroxy;X is O, N, S or C;Y is O, N or S; andR.sub.2 is H, alkyl, cycloalkyl, aryl or heteroaryl useful in the treatment of ischemic heart disease and hypertriglyceridemia.Type: GrantFiled: March 28, 1984Date of Patent: April 1, 1986Assignee: USV Pharmaceutical Corp.Inventors: John H. Musser, Charles A. Sutherland
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Patent number: 4579866Abstract: Compounds of the structure ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sub.1 and R.sub.2 are independently H, OH, lower alkyl, lower alkoxy, aryloxy, heteroaryloxy, heteroaryl lower alkoxy, aryl, heteroaryl, aryl-lower alkyl, aryl-lower alkoxy, halogenated aryl-lower alkoxy, lower alkenyl, lower alkynyl, lower alkenoxy, lower alkynoxy, halogen or trifluoromethyl;A is H, aryl, lower alkyl, aryl-lower alkyl or heteroaryl; andB is ##STR2## n=0-6, wherein D is H, CONR.sub.3 R.sub.4, CO.sub.2 H, CO.sub.2 R.sub.5, CH.sub.2 OH or CH.sub.2 OR.sub.6,whereinR.sub.3, R.sub.4, R.sub.5 and R.sub.6 are independently H, lower alkyl, aryl, aryl-lower alkyl or heteroaryl;E is H, OH, lower alkyl, aryl or heteroaryl; andF is ##STR3## wherein G is the same as R.sub.1 and R.sub.2, useful for the treatment of allergy, asthma and inflammatory conditions.Type: GrantFiled: May 29, 1984Date of Patent: April 1, 1986Assignee: USV Pharmaceutical Corp.Inventors: David Stevenson, Robert C. Liu, Laurence L. Ho, Howard Jones, Stephen Coutts
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Patent number: D286919Type: GrantFiled: August 31, 1984Date of Patent: November 25, 1986Assignee: USV Pharmaceutical Corp.Inventors: James W. Flockhart, Joseph Barone
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Patent number: D290412Type: GrantFiled: September 13, 1984Date of Patent: June 16, 1987Assignee: USV Pharmaceutical Corp.Inventor: Stephen C. Downs