Patents Assigned to USV Pharmaceutical Corporation
-
Patent number: 5200416Abstract: Compounds of the formula ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, and R.sub.7 are independently hydrogen or lower alkyl.R.sub.5 is hydrogen, lower alkyl, rad alkanoyl having 1 to 6 carbon atoms.Y is OH or OM wherein M is a pharmaceutically acceptable cation, andn is an integer from 0 to 1, andX.sub.1 and X.sub.2 are independently (CR.sub.8 R.sub.9).sub.mwherein R.sub.8 and R.sub.9 are independently hydrogen or lower alkyl and m is an integer from 1 to 5 are potent angiotensin converting enzyme inhibitors and possess antihypertensive activity.Type: GrantFiled: May 12, 1980Date of Patent: April 6, 1993Assignee: USV Pharmaceutical CorporationInventors: John T. Suh, Jerry W. Skiles, Bruce E. Williams
-
Patent number: 4794188Abstract: Compounds of the formula:Ar.sub.1 -X-Ar-Z-(R).sub.n'and salts thereof, whereinAr.sub.1 is a nitrogen, sulfur or oxygen heterocyclic ring;Ar is a phenyl ring or a nitrogen, oxygen or sulfur heterocyclic ring;Ar and Ar.sub.1 may be fully substituted or less than fully substituted with H, CH.sub.3, lower alkyl, aryl, aralkyl, halo, hydroxy, lower alkoxy, CF.sub.Type: GrantFiled: December 19, 1985Date of Patent: December 27, 1988Assignee: USV Pharmaceutical CorporationInventors: John H. Musser, Utpal R. Chakraborty
-
Patent number: 4778931Abstract: The invention relates to several aryloxy-alkane alcohols, for example 1-(3-(1-hydroxy-1-methylhexyl) phenoxy methyl)-2-methoxy-naphthalene, 2-(1-(3-(1-hydroxy-2,2-dimethylhexyl)phenoxy)ethyl naphthalene, 1-(3-6-phenoxy-1-hydroxyhexyl)phenoxy methyl)-4-methoxy naphthalene, 2-(3-(1-hydroxyhexyl) phenoxymethyl) naphthalene and 2-(3-(1-hydroxyhexyl)phenoxymethyl)-1,2,3,4-tetrahydro naphthalene, methods for their preparation and their use for treating inflammatory and allergic conditions in a mammal.Type: GrantFiled: November 29, 1985Date of Patent: October 18, 1988Assignee: USV Pharmaceutical CorporationInventors: John H. Musser, Utpal R. Chakraborty
-
Patent number: 4762945Abstract: Process for preparing 2,2'-diacetoxy-dibenzoylperoxide by: reacting 2-acetyl-salicyloyl chloride with aqueous hydrogen peroxide in a reaction mixture medium of tetrahydrofuran and dichloromethane in the presence of an organic base; separating a dichloromethane extract; diluting the dichloromethane extract with methanol and crystallizing the anhydrous product therefrom.Type: GrantFiled: September 12, 1985Date of Patent: August 9, 1988Assignee: USV Pharmaceutical CorporationInventor: Frederick A. Golec, Jr.
-
Patent number: 4740373Abstract: Disclosed are aqueous multivitamin/trace elements formulations stabilized by a water soluble, organic acid that contains carbon-to-carbon unsaturation and water soluble salts thereof selected from the group consisting of maleic acid, fumaric acid, maleamic acid and acrylic acid.Type: GrantFiled: May 27, 1986Date of Patent: April 26, 1988Assignee: USV Pharmaceutical CorporationInventors: Morris Kesselman, Abdur R. Purkaystha, James Cahill
-
Patent number: 4728668Abstract: The present invention is concerned with the therapeutic composition comprising as an active ingredient a compound of the formula:(R.sub.1)(R.sub.2) Ar--Z--M--Ar.sub.1 (R.sub.3)(R.sub.4) Iand salts thereof;whereinAr and Ar.sub.1 are independently phenyl, naphthyl or a nitrogen, oxygen, or sulfur heterocyclic ring;Z is an alkylene chain containing from 1 to 5 carbon atoms in the principal chain and up to a total of 10 carbon atoms;M is oxygen, sulfur, or NR.sub.5 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently H, lower alkyl, lower alkoxy, hydroxy, halo, trihalomethyl, hydroxy lower alkyl, carboxy, formyl, aryl, aryloxy, benzyloxy, lower alkanoyl, carboxy lower alkoxy, nitro, amino, lower alkylamino, dilower alkylamino, cyano, lower alkanoyloxy, carbamoyl, lower alkoxy-alkoxy, carbo-lower alkoxy-alkoxy, or tetrahydropyranylmethyl; andR.sub.5 is hydrogen or lower alkyl.Type: GrantFiled: June 23, 1986Date of Patent: March 1, 1988Assignee: USV Pharmaceutical CorporationInventors: Utpal R. Chakraborty, Raymond D. Youssefyeh
-
Patent number: 4725619Abstract: The present invention is concerned with the therapeutic composition comprising as an active ingredient a compound of the formula:(R.sub.1)(R.sub.2) Ar--Z--M--Ar.sub.1 (R.sub.3)(R.sub.4) Iand salts thereof; whereinAr and Ar.sub.1 are independently phenyl, naphthyl or a nitrogen, oxygen, or sulfur heterocyclic ring;Z is an alkylene chain containing from 1 to 5 carbon atoms in the principal chain and up to a total of 10 carbon atoms;M is oxygen, sulfur, or NR.sub.5 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently H, lower alkyl, lower alkoxy, hydroxy, halo, trihalomethyl, hydroxy lower alkyl, carboxy, formyl, aryl, aryloxy, benzyloxy, lower alkanoyl, carboxy lower alkoxy, nitro, amino, lower alkylamino, dilower alkylamino, cyano, lower alkanoyloxy, carbamoyl, lower alkoxy-alkoxy, carbo-lower-alkoxy-alkoxy, or tetrahydropyranylmethyl; andR.sub.5 is hydrogen or lower alkyl.Type: GrantFiled: June 23, 1986Date of Patent: February 16, 1988Assignee: USV Pharmaceutical CorporationInventors: Utpal R. Chakraborty, Raymond D. Youssefyeh
-
Patent number: 4722939Abstract: This invention relates to novel compounds having pharmaceutical activity and having the general structure ##STR1## wherein the Z, R.sub.1, R.sub.2, R.sub.3, R.sub.4, n and m are defined within.Type: GrantFiled: December 4, 1984Date of Patent: February 2, 1988Assignee: USV Pharmaceutical CorporationInventors: Bernard Loev, Howard Jones, Wan-kit Chan
-
Patent number: 4701461Abstract: Compounds of the formulae: ##STR1## wherein, Z and Y are each alkylene or oxy-alkylene containing one to about five carbon atoms in the principal chain or said alkylene subtituted with OH, alkanoyloxy, alkoxy, mercapto or alkylmercapto;each of R.sub.1, R.sub.2 and R.sub.3 is independently H, alkyl, aryl, halo, alkoxy, alkenyloxy, alkylsulfinyl, alkylsulfonyl, alkylmercapto, cyano, carboxy, carbalkoxy, carboxamido, sulfamoyl, trifluoromethyl, hydroxy, hydroxyalkyl, acyloxy, alkylamino, sulfonylamino or acylamino; or R.sub.1 and R.sub.2, when taken together, form a methylenedioxy or --O--CO--O--;Ar is heteroaryl, cycloalkyl or ##STR2## wherein, R.sub.1, R.sub.2 and R.sub.3 are as herein described; andR is H, alkyl, cycloalkyl, aryl, aralkyl, alkenyl, alkynyl, carboalkoxy, or CONR.sub.4 R.sub.5 wherein each of R.sub.4 and R.sub.5 is H or alkyl; wherein the total number of carbon atoms in each hydrocarbyl group is up to 10; and ##STR3## wherein, each of R.sub.1 and R.sub.Type: GrantFiled: September 2, 1986Date of Patent: October 20, 1987Assignee: USV Pharmaceutical CorporationInventors: John T. Suh, Jeffrey N. Barton
-
Patent number: 4698346Abstract: New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formula: ##STR1## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl,Y is oxygen, sulfur, nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, aralkyl, acyl, aminoalkyl, or carboxyalkyl,Z is oxygen, sulfur or nitrogen,X is cyano, carbalkoxyl, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, andm is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or as intermediates in the preparation of compounds useful for treating asthma.Type: GrantFiled: July 24, 1986Date of Patent: October 6, 1987Assignee: USV Pharmaceutical CorporationInventors: John H. Musser, Richard E. Brown
-
Patent number: 4696939Abstract: Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.Type: GrantFiled: November 29, 1985Date of Patent: September 29, 1987Assignee: USV Pharmaceutical CorporationInventors: John T. Suh, John J. Piwinski, Howard Jones, Edward S. Neiss
-
Patent number: 4694023Abstract: Polyolefinic compounds represented by the general formula ##STR1## in which R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R.sub.2 is an alkyl group of from 1 to 5 carbon atoms; R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2, NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof.The foregoing compounds have been found to be effective in the treatment of psoriasis, inflammatory conditions and allergic responses.Type: GrantFiled: March 11, 1985Date of Patent: September 15, 1987Assignee: USV Pharmaceutical CorporationInventors: Bernard Loev, Wan-kit Chan, Howard Jones
-
Patent number: 4686295Abstract: This invention relates to new compounds of the formula ##STR1## wherein A is a hydroxy, lower alkoxy, lower alkenoxy, diloweralkylamino lower alkoxy, acylamino lower alkoxy, acyloxy, lower alkoxy, aryloxy, arloweralkyloxy, amino, loweralkylamino, diloweralkylamino, aryloweralkylamino, hydroxyamino, or substituted aryloxy, or substituted arloweralkoxy wherein the substituent is methyl, halo or methoxy;R.sub.1, R.sub.2, and R.sub.Type: GrantFiled: March 7, 1983Date of Patent: August 11, 1987Assignee: USV Pharmaceutical CorporationInventors: Raymond D. Youssefyeh, Jerry W. Skiles, John T. Suh, Howard Jones
-
Patent number: 4681973Abstract: Acylated amino acids having the general formula ##STR1## are prepared by reacting a compound of formula II ##STR2## with a compound of formula IIIROCOClwherein R, R.sub.1, R.sub.2 and R.sub.3 are as defined herein.Type: GrantFiled: February 27, 1986Date of Patent: July 21, 1987Assignee: USV Pharmaceutical CorporationInventor: Martin L. Kantor
-
Patent number: 4668678Abstract: New triazoloquinoxalin-1,4-diones are described as well as the use thereof as anti-allergenic agents.Type: GrantFiled: February 22, 1985Date of Patent: May 26, 1987Assignee: USV Pharmaceutical CorporationInventors: Richard E. Brown, Vassil St. Georgiev, Philip Kropp, Bernard Loev
-
Patent number: 4668694Abstract: This disclosure describes novel pharmaceutical compositions of matter which possess useful anti-inflammatory and anti-allergic properties, the active ingredients of said compositions of matter being compounds of the formula ##STR1## wherein Ar and Ar.sub.1 are each independently phenyl or naphthyl or a nitrogen, oxygen or sulfur-heterocyclic ring;Z is an alkylene chain containing from 0 up to 5 carbons in the principal chain and up to a total of 7 carbons;X is O or S;Y is .dbd.O;R and R.sub.1 are independently hydrogen, hydroxy, lower alkoxy, lower alkanoyloxy, halo, cyano, carboloweralkoxy, carboxyloweralkyl, aryloxy or benzyloxy;R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl, lower aralkyl, lower alkenyl, lower alkynyl, aryl or carboxyloweralkyl and the pharmaceutically acceptable salts thereof.Type: GrantFiled: April 22, 1986Date of Patent: May 26, 1987Assignee: USV Pharmaceutical CorporationInventor: Fu-chih Huang
-
Patent number: 4666906Abstract: Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.Type: GrantFiled: July 19, 1985Date of Patent: May 19, 1987Assignee: USV Pharmaceutical CorporationInventors: John J. Piwinski, John T. Suh, Paul Menard, Howard Jones, Edward S. Neiss, John R. Regan
-
Patent number: 4661515Abstract: Novel compounds possessing both angiotensin enzyme inhibitory activity and diuretic activity are disclosed. The compounds are represented by the general formula ##STR1## in which X is ##STR2## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, and cycloalkyl, and may be the same or different; n is an integer from 0 to 4 inclusive; M is alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cyloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, or dialkylaminoalkyl, or M and R.sub.6 taken together with the nitrogen to which M is bonded and the carbon to which R.sub.Type: GrantFiled: January 17, 1986Date of Patent: April 28, 1987Assignee: USV Pharmaceutical CorporationInventors: Edward S. Neiss, John T. Suh, John J. Piwinski
-
Patent number: 4659711Abstract: Compounds of the general formula ##STR1## and their pharmaceutically-acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.Type: GrantFiled: October 4, 1985Date of Patent: April 21, 1987Assignee: USV Pharmaceutical CorporationInventors: Fu-chin Huang, Howard Jones, Wan-Kit Chan
-
Patent number: 4650854Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which are amide analogs of natural calcitonins.Type: GrantFiled: June 6, 1985Date of Patent: March 17, 1987Assignee: USV Pharmaceutical CorporationInventors: Edward S. Neiss, David Stevenson, Laurence L. Ho, Robert C. Liu, John T. Suh