Abstract: The present invention relates to a stent having a functional material coated on a cell space (safe coating space) thereof. The stent of the present invention, as a stent having a space for mounting and coating drugs and other materials for expanding the functions of the stent, is highly feasible as an actual product in consideration of the structure, transfer device, and manufacturing process of the stent as a whole, and secures a coating space (safe coating space) of a functional material in a cell of the stent through quantitative and qualitative modelling. Since an additional increase in volume does not occur even when the stent is press-mounted in a transfer device as a result of mounting a radio marker or a drug in the coating space, the stent of the present invention has excellent radio opacity without obstructing the loading and deployment of the stent, and may stably mount a great amount of a functional drug.
Type:
Grant
Filed:
March 9, 2016
Date of Patent:
October 15, 2019
Assignees:
UTAH-INHA DDS & ADVANCED THERAPEUTICS RESEARCH CENTER, NEXTBIOMEDICAL CO., LTD.
Inventors:
Don Haeng Lee, Jong Chae Park, Dong Gon Kim, Choong Ryeol Choi
Abstract: The present invention provides a biodegradable medical adhesive or a sealant composition containing an oxidized glycosaminoglycan and a polyamine. The composition of the present invention exhibits improved effects in biodegradation, coating property, gelation time, hemostatic capacity, adhesive force, moisture absorptive capacity and the like, and thus can be applied to various medical uses in which a medical adhesive or sealant can be used, such as biotissue adhesion, filling, coating, adhesion prevention, wound covering, leakage prevention and hemostasis.
Type:
Grant
Filed:
December 12, 2014
Date of Patent:
October 23, 2018
Assignee:
UTAH-INHA DDS & ADVANCED THERAPEUTICS RESEARCH CENTER
Inventors:
Eunhye Lee, Jin Hee Maeng, Keun Su Kim, Don Haeng Lee, Young Hwan Park
Abstract: The present invention provides administrable microparticles in vivo through a medical conduit, a composition comprising the same, and a manufacturing method therefor. The microparticles of the present invention have an advantage that a clogging phenomenon does not occur for an endoscopic administration through a spray apparatus.
Type:
Grant
Filed:
January 21, 2015
Date of Patent:
June 26, 2018
Assignee:
UTAH-INHA DDS & ADVANCED THERAPEUTICS RESEARCH CENTER
Inventors:
Eunhye Lee, Keun Su Kim, Don Haeng Lee, Young Hwan Park
Abstract: The present invention relates to a biodegradable microbead having improved adsorptive power to anticancer drugs, to a method for preparing same, and to a method for treating cancer using same. According to the present invention, a rigid bead having excellent adsorptive power to anticancer drugs can be prepared through cross-linking and an amide bond between an albumin and an anionic polymer. Also, the microbead of the present invention is prepared by a biocompatible and biodegradable polymer so as to be safe when applied to the human body. Further, the microbead of the present invention can effectively inhibit the growth of a tumor by effectively blocking a blood vessel which supplies nutrients to a liver tumor, while continuously releasing anticancer drugs which are adsorbed into the surface of the bead. Thus, the present invention can be usefully applied to a chemoembolization of liver cancer.
Type:
Grant
Filed:
November 15, 2013
Date of Patent:
June 19, 2018
Assignee:
UTAH-INHA DDS & ADVANCED THERAPEUTICS RESEARCH CENTER
Abstract: The present invention provides a pharmaceutical composition in a powder form for providing wound protection, hemostasis, or anti-adhesion in the gastrointestinal tract, which comprises a certain mucoadhesive polymer; and a certain hygroscopic agent.
Type:
Grant
Filed:
October 31, 2013
Date of Patent:
March 20, 2018
Assignees:
DAEWOONG CO., LTD., CG BIO CO., LTD., UTAH-INHA DDS & ADVANCED THERAPEUTICS RESEARCH CENTER
Inventors:
In-Ae Kim, Sang-Hee Kim, Ji-Hoon Jung, Hee-Chul Chang, Jin-Hee Maeng, Su-Geun Yang, Don-Haeng Lee, Kyung-Hyun Min
Abstract: The present invention relates to a reducing or non-reducing polynucleotide polymer for drug delivery and a method for preparing same, and provides a reducing or non-reducing polymer synthesized by using nucleotides, a method for preparing same, and a polymer composition for drug delivery containing the reducing or non-reducing polymer. The present invention relates to a drug delivery carrier for delivering proteins or peptides to a targeted area through electrostatic attraction, by obtaining a negatively (?) charged polymer by using nucleotides to synthesize the reducing or non-reducing polymer, which is easily breakable due to disulfide bonds, and then bonding the negatively (?) charged polymer with a positively (+) charged protein or peptide, wherein a polymer derived from a non-viral drug delivery carrier containing the novel reducing or non-reducing polymer is capable of effectively enabling escape of a drug, delivered by means of proton buffering activity, from an endosome to other organelles in a cell.
Type:
Application
Filed:
June 20, 2014
Publication date:
July 7, 2016
Applicants:
THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION, UTAH-INHA DDS & ADVANCED THERAPEUTICS RESEARCH CENTER
Abstract: The present invention provides a pharmaceutical composition in a powder form for providing wound protection, hemostasis, or anti-adhesion in the gastrointestinal tract, which comprises a certain mucoadhesive polymer; and a certain hygroscopic agent.
Type:
Application
Filed:
October 31, 2013
Publication date:
December 10, 2015
Applicants:
DAEWOONG CO., LTD., CG BIO CO., LTD., UTAH-INHA DDS & ADVANCED THERAPEUTICS RESEARCH CENTER
Inventors:
In-Ae KIM, Sang-Hee KIM, Ji-Hoon JUNG, Hee-Chul CHANG, Jin-Hee MAENG, Su-Geun YANG, Don-Haeng LEE, Kyung-Hyun MIN