Abstract: This invention provides novel methods of and kits for labeling and isolating lumen-exposed molecules, particularly polypeptides which are expressed in a tissue-specific or organ-specific manner. The methods and kits can be used to isolate molecules exposed on the luminal side of cells lining vascular, ductal, sinus, respiratory, fascial, and other perfusible tissue spaces.
Abstract: The present invention provides novel methods and kits for labeling and isolating tissue-specific or organ-specific lumen-exposed molecules. In addition, the present invention provides tissue-specific or organ-specific lumen-exposed polypeptides, which were isolated by the methods herein. Furthermore the present invention provides therapeutic complexes comprising ligands that bind the tissue-specific or organ-specific lumen-exposed polypeptides attached to therapeutic moieties for targeted treatment and prevention.