Abstract: In alternative embodiments, the invention provides formulations, pharmaceutical compositions, devices and other products of manufacture comprising a therapeutically effective mixture of an insulin and a pramlintide, and methods for making and using them.

Abstract: The present invention relates to microfluidic devices, and in particular, flow management in such devices. In particular, the present invention provides an electrostatic valve for flow manipulation in a microfluidic device. The valve of the present invention sits on a valve seat in a microchannel and deflects away from the valve seat by electrostatic actuation to assume an opened configuration to allow fluid flow.

Abstract: The administration of the PAF antagonists BN 52021 and SR 27417, in combination with cyclooxygenase antagonist indomethacin are disclosed as effective in inhibiting the secretory effects caused by Cholera toxin.

Abstract: A convenient, non-optical method for scanning probe microscopy tip-to-sample distance control based on the impedance change in a shear-force dither piezo. This is accomplished by determining the tip-sample distance by measuring the impedance change in a shear-force piezo-member. A Wheatstone type bridge can be utilized to regulate the tip-sample separation. Alternatively, an electrical bridge, having an output, regulates the tip-sample separation relative to the bridge output by driving the piezo/tip with a sine wave and combining said sine wave with a phase-referenced wave of equal amplitude at a 180.degree. phase shift. The electronic bridge detects impedance changes of about -100 dB across loads with impedance phases between -90.degree. to +90. Power dissipation is determined by measuring changes in electric impedance that a dither piezo presents to an oscillator.

Abstract: The instant invention discloses a method of treating hyperactive voiding associated with excessive nerve growth factor production and nerve growth in patients by administering a Ca.sup.++ channel blocker. The Ca.sup.++ channel blockers verapamil and diltiazem can be administered systemically to treat hyperactive voiding, such as is associated with benign prostatic hyperplasia and interstitial cystitis.

Abstract: An esophageal perfusion catheter, having an outer housing, a plurality of flexible, tubular channel members within said outer housing, and at least two spaced balloon members encompassing said catheter. Two of the channel members are in fluid communication with each of two balloons. One of the balloons is about 150 millimeters from the distal end of said catheter and about 75 millimeters from the other balloon. A third of the tubular channel members is an esophageal perfusion aspirating channel and is in communication with a port at the distal end of the catheter. A fourth of the tubular channel members serves as a gastric aspirating channel. A fifth of the tubular channel members serves as an aspirating channel. The sixth channel member, serves as an air vent. The esophageal perfusion aspirating channel has a ID of about 3 millimeters. The gastric aspirating channel has a ID of about 2 millimeters. The two channel members which communicate with the balloons have a ID of about 1 millimeter.