Patents Assigned to Vascular Laboratory, Inc.
  • Production of human prourokinase
    Patent number: 5866358
    Abstract: A method is provided for producing non-glycosylated single chain prourokinase (proUK). The method comprises cultivating bacterial strains of E. coli which have been transformed with plasmids carrying the cDNA sequence coding for proUK.
    Type: Grant
    Filed: July 11, 1990
    Date of Patent: February 2, 1999
    Assignee: Vascular Laboratory Inc.
    Inventors: Anna Brandazza, Paolo Sarmientos, Gaetano Orsini
  • Lysis of fibrin blood clots with urokinase and pro-urokinase
    Patent number: 5055295
    Abstract: The thrombolytic effect of the plasminogen activator pro-urokinase is improved synergistically by the co-administration of urokinase. The two components may be administered sequentially or simultaneously, and if simultaneously, either separately or as a mixture. Preferably an initial bolus injection of urokinase is followed by an infusion of pro-urokinase.
    Type: Grant
    Filed: May 2, 1989
    Date of Patent: October 8, 1991
    Assignee: Vascular Laboratory, Inc.
    Inventors: Dieter Welzel, Helmut Wolf