Abstract: The invention is directed to peptide modulators of Pin1 and Pin1-related proteins and the use of such modulators for treatment of Pin1 associated states, e.g., for the treatment of cancer or neurodegenerative disease.
Type:
Application
Filed:
July 15, 2005
Publication date:
September 4, 2008
Applicants:
VERNALIS PLC, BETH ISRAEL DEACONESS MEDICAL CENTER, THE SALK INSTITUTE FOR BIOLOGICAL STUDIES
Inventors:
Kun Ping Lu, Robert K. Suto, Janusz M. Sowadski, Gunter S. Fischer, Joseph P. Noel, Mark Verdecia
Abstract: This invention relates to methods of determining the prognosis of a subject with a Pin1 associated disorder by evaluating the levels of phosphorylated Pin1 in a biological sample. The invention also provides Pin1 polypeptides phosphorylated position 16, position 71, or both. The invention further relates to a crystal structure of a pPin1(71) polypeptide and a pPin1(16)(71) polypeptide. The invention also provides constitutively active mutants of Pin1 and modulators that are specific for the molecules. The invention further provides methods for determining if a subject is at risk of developing a Pin1 associated state by determining if a the subject has a mutation in Pin1 that renders the polypeptide constitutively active.
Type:
Application
Filed:
July 15, 2005
Publication date:
April 6, 2006
Applicants:
VERNALIS PLC, BETH ISRAEL DEACONESS MEDICAL CENTER
Inventors:
Kun Lu, Janusz Sowadski, Robert Suto, Timothy McKee, Amy Kimzey, Futoshi Suizu