Abstract: The invention generally concerns a novel family of biocompatible surfactant copolymers having a wide range of uses, in particular in pharmaceutics and for synthesizing substances in dispersed state and for surface treatment of materials or biomaterials. Said copolymers are characterised in that they comprise a hydrophobic sequence constituted by: either a homopolymer consisting of recurrent units corresponding to the general formula (I): in which: R1 represents a C1-C6 alkyl group or a (CH2)m—COOR3 group wherein m is an integer between 1 and 5 and R3 represents a C1-C6 alkyl group; R2 represents a C1-C6 alkyl group; and n is an integer between 1 and 5; or a random copolymer consisting of different recurring units corresponding to formula (I) as defined above; or finally a random copolymer consisting for the major part of units corresponding to formula (I) as defined above.

Abstract: A method for the suture of wounds, includes applying a sufficient quantity of a biocompatible, bio-adhesive mixture with at least 50% by weight of a methylidene malonate-based composition containing: 40 to 100% by weight of at least one methylidene malonate of formula (I):  in which: A and B independently represent a group (a) or (b): in which R1 and R2 independently represent a linear or branched alkyl group with 1 to 6 carbon atoms, n is an integer between 1 and 5, and at least one of A and B represents a (b) group; and/or one or more methylidene malonate oligomers with a molecular weight less than or equal to 6,000 and including recurrent units of formula (II): in which A and B are as defined above; and 0 to 60% by weight of at least one methylidene malonate polymer with a molecular weight greater than 6,000 and including recurrent units of formula (II).

Abstract: The invention concerns novel microspheres particularly useful in pharmaceutics as particulate vectors for carrying biologically active substances, in particular hydrophilic substances, for oral administration. The invention is characterised in that said microspheres consist of a support material continuous lattice wherein is optionally dispersed a substance, said support material containing at least 70 wt. % of a homopolymer consisting of recurrent units corresponding to general formula (I): wherein: R1 represents an alkyl group containing 1 to 6 carbon atoms or a (CH2)m—COOR3 group wherein m is an integer ranging between 1 and 5 and R3 represents an alkyl group having 1 to 6 carbon atoms; R2 represents an alkyl group having 1 to 6 carbon atoms; and n is an integer ranging between 1 and 5. The invention is useful in pharmaceutics.

Abstract: The invention concerns a method for the mechanochemical treatment of a material characterised in that to improve said material surface properties by mechanochemical anchoring, such as in particular its adhesive capacity during subsequent assembling, or to improve its use properties by producing composite structure surface coatings, consisting in projecting on said material particles with laminated structure consisting of a core and a coating comprising at least a polymer and optionally a chemical agent, in conditions such that said particles and/or fragments resulting from their fracturing are embedded and/or penetrate into said material. The invention is applicable in dentistry, the biomedical field, motor industry, avionics, printing industries, agro-industry, mechanical industries.

Abstract: Nanoparticles formed from a random polymer of at least one compound of formula (I) in which A represents a group or a group; R1 and R2, identical or different, represent a linear or branched C1-C6 alkyl group; n=1, 2, 3, 4 or 5, having a diameter of less than 500 nm and an average molecular mass (Mw) between about 8000 and 100000, the nanoparticles being formed from homogeneous molecular species, and optionally containing a biologically active material.

Abstract: The invention relates to a method for the preparation of nanoparticles formed from a random polymer of at least one compound of formula (I) 1

Abstract: The invention relates to a method for the preparation of nanoparticles formed from a random polymer of at least one compound of formula (I) in which A represents a  group or a  group; R1 and R2, identical or different, represents a linear or branched C1-C6 alkyl group; n=1, 2, 3, 4 or 5, characterised in that the monomer is dissolved beforehand in a water-miscible aprotic organic solvent forming, with the polymerisation medium, a non-solvent mixture of the polymer formed.