Patents Assigned to VU-VUMC IP MANAGEMENT BV
  • Methods of diagnosing and treating heart failure
    Patent number: 10393754
    Abstract: This invention relates to novel phosphorylation sites in cardiac Troponin I that are associated with the onset of heart failure. The phosphorylation sites, i.e., serine 5, tyrosine 26, threonine 51, serine 166, threonine 181 and/or serine 199, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: August 27, 2019
    Assignees: CEDARS-SINAI MEDICAL CENTER, VU-VUMC IP MANAGEMENT BV
    Inventors: Pingbo Zhang, Jennifer E. Van Eyk, Anne M. Murphy, Ger Stienen, Jolanda van der Velden, Viola Kooij
  • Novel Phosphorylation of Cardiac Troponin I as a Monitor for Cardiac Injury
    Publication number: 20130101606
    Abstract: This invention relates to novel phosphorylation sites in cardiac Troponin I that are associated with the onset of heart failure. The phosphorylation sites, i.e., serine 5, tyrosine 26, threonine 51, serine 166, threonine 181 and/or serine 199, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention.
    Type: Application
    Filed: February 17, 2011
    Publication date: April 25, 2013
    Applicants: VU-VUMC IP MANAGEMENT BV, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Pingbo Zhang, Jennifer E. Van Eyk, Anne M. Murphy, Ger Stienen, Jolanda van der Velden, Viola Kooij