Patents Assigned to Vysoka skola chemicko-technologicka
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Publication number: 20230074000Abstract: A device for preparation of liquid marbles that has a belt conveyor for carrying a layer of solid particles, the belt conveyor being provided, successively in the direction of movement of the belt with at least one solids dispenser with a reservoir for solid particles, at least one liquid dispenser with a reservoir for liquid, and a separator for separating the prepared liquid marbles from solid particles, is disclosed.Type: ApplicationFiled: February 17, 2021Publication date: March 9, 2023Applicant: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZEInventors: Ondrej RYCHECKY, Frantisek STEPANEK, Martin KROV
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Patent number: 11492327Abstract: New aminooxylipids of general formula I, wherein n1=5-30 and X is polymethylene linker of the general formula II where n2=2-10, or X is polyethylene glycol linker of the general formula III, wherein n3=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C—O—(C?O)—HN—(CH2)n—NH2, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C—O—(C?O)—HN—(CH2)2—[O—(CH2)]n—O—(CH2)2NH2, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n1=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n1=5-30, produces N-Boc-aminolipids of general formula VI, wherein n1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.Type: GrantFiled: November 2, 2017Date of Patent: November 8, 2022Assignees: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V. V. I., APIGENEX S.R.O.Inventors: Miroslav Ledvina, Roman Effenberg, Jaroslav Turanek, Elissa Bartheldyova, Ladislav Droz, Josef Masek, Frantisek Hubatka
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Publication number: 20220192985Abstract: A formulation of composites having yeast-derived beta glucan particles (GPs) and water-insoluble or poorly-water-soluble low-molecular-weight compounds, such as medicaments or food supplements is disclosed. The composites can exhibit different crystallinity degrees depending on the formulation and, consequently, dissolution kinetics can be controlled. Yeast-derived beta glucan particles are used as carriers for the encapsulation and amorphization of insoluble or poorly water-soluble low-molecular-weight compounds; amorphous formulations exhibiting faster dissolution rates, and consequently, enhanced oral bioavailability. A method of preparation of the composites by spray drying is also disclosed.Type: ApplicationFiled: April 2, 2020Publication date: June 23, 2022Applicant: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZEInventors: Gabriela RUPHUY CHAN, Frantisek STEPANEK, Jaroslav HANUS, Petra SALAMUNOVA, Ivan SALON
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Publication number: 20210292275Abstract: New aminooxylipids of general formula I, wherein n1=5-30 and X is polymethylene linker of the general formula II where n2=2-10, or X is polyethylene glycol linker of the general formula III, wherein n3=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C—O—(C?O)—HN—(CH2)n—NH2, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C—O—(C?O)—HN—(CH2)2—[O—(CH2)]n—O—(CH2)2NH2, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n1=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n1=5-30, produces N-Boc-aminolipids of general formula VI, wherein n1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.Type: ApplicationFiled: November 2, 2017Publication date: September 23, 2021Applicants: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V.V.I., APIGENEX S.R.O.Inventors: Mirolav LEDVINA, Roman EFFENBERG, Jaroslav TURANEK, Elissa BARTHELDYOVA, Ladislav DROZ, Josef MASEK, Frantisek HUBATKA
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Patent number: 9932339Abstract: Helquat derivatives of general formula I, in which substituents R1 and R2 are independently selected from a group comprising H and C1 to C4 alkyl, up to three of S1,2, S1?,2?, S3,4 and S3?,4? are present, each of S1,2, S1?,2?, S3,4 and S3?,4? independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms, preferably hydrocarbon chain having 4 carbon atoms, and one to four atoms selected from the carbon atoms with the descriptor 2, 4, 2?, and 4? are substituted with a substituent R3 of general formula II, wherein R4 is substituted or unsubstituted heteroaryl, T1 and T2 are independent linkers that bridge atoms N5 with C8 and N5? with C8?, wherein T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms, preferably 2 or 3 carbon atoms; and anions (X1)? and (X2)? independently represent anions of pharmaceutically acceptable salts.Type: GrantFiled: May 26, 2015Date of Patent: April 3, 2018Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZEInventors: Filip Teply, Miroslav Hajek, Erika Kuzmova, Jaroslav Kozak, Veronika Komarkova, Pavla Hubalkova, Paul Eduardo Reyes-Gutierrez, Michael Jirasek, Manoj R. Sonawane, Vishwas D. Joshi, Lukas Severa, Jana Novotna
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Publication number: 20170096433Abstract: Helquat derivatives of general formula I, in which substituents R1 and R2 are independently selected from a group comprising H and C1 to C4 alkyl, up to three of S1,2, S1?,2?, S3,4 and S3?,4? are present, each of S1,2, S1?,2?, S3,4 and S3?,4? independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms, preferably hydrocarbon chain having 4 carbon atoms, and one to four atoms selected from the carbon atoms with the descriptor 2, 4, 2?, and 4? are substituted with a substituent R3 of general formula II, wherein R4 is substituted or unsubstituted heteroaryl, T1 and T2 are independent linkers that bridge atoms N5 with C8 and N5? with C8?, wherein T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms, preferably 2 or 3 carbon atoms; and anions (X1)? and (X2)? independently represent anions of pharmaceutically acceptable salts.Type: ApplicationFiled: May 26, 2015Publication date: April 6, 2017Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZEInventors: Filip TEPLY, Miroslav HAJEK, Erika KUZMOVA, Jaroslav KOZAK, Veronika KOMARKOVA, Pavla HUBALKOVA, Paul Eduardo REYES-GUTIERREZ, Michael JIRASEK, Manoj R. SONAWANE, Vishwas D. JOSHI, Lukas SEVERA, Jana NOVOTNA
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Patent number: 8013190Abstract: The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, ?1 or ?2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability.Type: GrantFiled: January 27, 2005Date of Patent: September 6, 2011Assignees: Vysoka Skola Chemicko-Technologicka V Praze, Ustav Organicke Chemie A Biochemie AV CZ, Ustav Anorganicke Chemie AV CZ, Department of Virology, University of HeidelbergInventors: Vladimír Král, Petr Cigler, Jan Konvalinka, Milan Kozísek, Jana Prejdová, Bohumír Grüner, Jaromír Plesek, Martin Lepsík, Jana Pokorná, Hans-Georg Kräusslich, Jochen Bodem
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Publication number: 20090012044Abstract: The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, ?1 or ?2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability.Type: ApplicationFiled: January 27, 2005Publication date: January 8, 2009Applicants: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CZ, USTAV ANORGANICKE CHEMIE AV CZ, DEPARTMENT OF VIROLOGY, UNIVERSITY OF HEIDELBERGInventors: Vladimir Kral, Petr Cigler, Jan Konvalinka, Milan Kozisek, Jana Prejdova, Bohumir Gruner, Jaromir Plesek, Martin Lepsik, Jana Pokorna, Hans-Georg Krausslich, Jochen Bodem
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Patent number: 4685935Abstract: A process for producing a pure magnesium sulphite from crude crystalline magnesium sulphite. Into a full suspension or flow containing magnesium sulphite crystals at least one further water-containing and heat-supplying flow is led. The heat-supplying flow rapidly increases the temperature of the suspension to above 80.degree. C. in less than 10 seconds, preferably in less than 2 seconds. The solid water-insoluble fraction is then separated from the resulting flow, and the pure product is recrystallized from the solution. The solution may be recycled into the process either for further purification or for use as at least one heat-supplying flow.Type: GrantFiled: June 26, 1986Date of Patent: August 11, 1987Assignee: Vysoka Skola chemicko-technologickaInventors: Stanislav Najmr, Zdenek Jerman, Jaroslav Kralicek
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Patent number: 4664810Abstract: Method of separating heavy metals from complex-forming substance of aminocarboxylic acid type, or salts thereof in aqueous solutions, as well as a method of removing heavy metals from the solutions containing said complex-forming substance. A solution containing heavy metals in complex form and complex-forming substances of aminocarboxylic acid type is contacted with a ion exchanger having polyethyleneimine active groups, whereupon free non-complexed heavy metal cations are displaced out of said ion exchanger by an acid solution of 0.5-30 percent concentration, and the ion exchanger is converted back into its active form by a solution of an alkali hydroxide, carbonate, or hydrogen carbonate of 0.5-30 percent concentration.Type: GrantFiled: May 30, 1985Date of Patent: May 12, 1987Assignee: Vysoka skola chemicko-technologickaInventors: Zdenek Matejka, Jarcslay Eliasek
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Patent number: 4624002Abstract: A circuit for performing a method melting vitreous materials in an electric furnace wherein the electrodes are supplied with an alternating current of optimal frequency lower than 60 or 50 Hz, respectively, the corrosion of electrodes being minimized. The circuit comprises a cycloconverter which changes a three-phase current supply into a single-phase current with a simultaneous changing of the input mains frequency into an optimal output frequency. The circuit also comprises a device for measuring and/or controlling the direct current component of the low frequency feeding alternating current, in order to stabilize the favorable anticorrosion effect of the low optimal frequency. Further, it comprises a device for the control of the power input of the cycloconverter with respect to the melting temperature in the furnace.Type: GrantFiled: July 18, 1985Date of Patent: November 18, 1986Assignee: Vysoka skola chemicko-technologickaInventors: Pavel Zahalka, Jaroslav Stanek, Jiri Matej
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Patent number: 4487841Abstract: There is disclosed a material for hot or plasma spraying, especially a material based on oxide ceramics, and a process for the production thereof. The composition of the invention is a mixture of powdered oxides containing at least two fundamental oxides with high melting point, and at least one glass-forming oxide the melting point of which is lower. The invention also includes a process for the production of such composition by the melting and agglomeration of individual components in the oxidizing medium of a plasma stream, including the special treatment of the starting components.Type: GrantFiled: February 12, 1982Date of Patent: December 11, 1984Assignee: Vysoka skola chemicko-technologickaInventors: Miloslav Bartuska, Petr Kroupa, Josef Szabo, Karel Zverina
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Patent number: 4343933Abstract: Process which accelerates the activated and non-activated polymerization of 2-pyrrolidone. A prepared polymerization charge containing monomer and components of the initiation system is first allowed to polymerize at a temperature above the monomer melting temperature, then is cooled below the melting point of the mixture, and then the crystalline reaction mixture is heated to a polymerization temperature of 25.degree. to 60.degree. C.Type: GrantFiled: September 26, 1980Date of Patent: August 10, 1982Assignee: Vysoka skola chemicko-technologickaInventors: Jan Roda, Jaroslav Kralicek
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Patent number: 4338509Abstract: Process of radial stabilization and homogenization of a plasma stream and a liquid stabilized plasma burner for the realization of such process. The arc is stabilized by its passage through several orifice plates, stabilized by a whirl or eddy of cooling liquid, then passes through a nozzle and is bent toward the peripheral surface of a rotatable anode lying out of the main outlet plasma stream issuing from the nozzle. The liquid stabilized burner has a rod cathode placed in the arc chamber, the cathode being progressively fed into the arc chamber to from an arc therewithin.Type: GrantFiled: November 14, 1980Date of Patent: July 6, 1982Assignee: Vysoka skola chemicko-technologickaInventors: Miloslav Bartuska, Karel Zverina, Josef Szabo, Borivoj Pospisil, Petr Kroupa
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Patent number: 4330568Abstract: A method of bonding at least two types of refractory ceramic materials, a first material being, for example, fireclay and a second material being, for example, alumina, to each other in order to enhance both the abrasion and corrosion resistances of heat resistant plates for valve closures of foundry ladles. The second, thermally more resistive material, which is applied to the first material in the form of relatively small particles, is preheated on at least the outer surface layers of the particles, the entire volume of the particles usually being preheated or even molten. The bonding of the two preheated materials occurs in such a way that minute particles up to drops of the second, thermally more resistive material are thrown at high speed (with high kinetic energy) onto the preheated surface of the first material. The source of such a relatively high kinetic energy can be constituted by either an explosion or a plasma beam ejected at a high outlet velocity out of the mouth of a plasma torch.Type: GrantFiled: January 21, 1980Date of Patent: May 18, 1982Assignee: Vysoka skola chemicko-technologickaInventors: Valter Boehm, Veslav Marosczyk, Antonin Cieslar, Miloslav Bartuska, Karel Rybak, Karel Zverina, Eduard Zelezny
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Patent number: 4325642Abstract: Kaolin suspension homogenizing and storage tank provided with at least a single mixing device mounted on its side wall. The mixing device includes a propeller or paddle impeller with inclined blades, the diameter of which is 1/15 to 1/30 of the diameter of the tank and the velocity of the blade tips of the impeller range from 6 to 12 m/s. The arrangement includes an alternative circulation pump and at least a single jet.Type: GrantFiled: September 4, 1980Date of Patent: April 20, 1982Assignee: Vysoka skola chemicko-technologickaInventors: Jiri Kratky, Ivan Fort, Petr Havel, Vaclav Machacek, Bohuslav Masek, Konstantin Hruban
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Patent number: 4304734Abstract: 6-amino-1-hydroxyhexylidene diphosphonic acid (I), salts of acid (I), and a process for the production thereof. Acid (I) has the summary formula ##STR1## Acid (I) and its salts are useful for pharmocologial purposes. In the production of acid (I) a mixture of phosphorous acid and phosphorous trichloride is reacted with the .epsilon.-aminocaproic acid or amide derived therefrom at a temperature from 50.degree. to 150.degree. C. The reaction can be carried out in the presence of an organic solvent, preferably chlorobenzene. Salt of the acid is produced by neutralization with one or two molecular equivalents of alkaline hydroxide, preferably sodium hydroxide.Type: GrantFiled: October 16, 1980Date of Patent: December 8, 1981Assignee: Vysoka skola chemicko-technologickaInventors: Jiri Jary, Veroslava Rihakova, Alena Zobacova
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Patent number: 4303778Abstract: A method is described for the anionic polymerization and copolymerization of .omega.-aminoacid lactams. This end is attained at elevated temperatures in the presence of a polymerization initiator of the formulaMeZX.sub.m L.sub.nwherein Me is an alkali metal, Z is boron or aluminum, X is an alkoxy group and L is an organic residue derived from a lactam and being of the formula ##STR1## wherein a is an integer in the range 3-11, m is an integer in the range of 0-3, (m+n) is 4 and n is (4-m).Type: GrantFiled: January 17, 1978Date of Patent: December 1, 1981Assignee: Vysoka skola chemicko-technologickaInventors: Jaroslav Kralicek, Vladimir Kubanek, Jiri Marik, Jaroslava Kondelikova, Jiri Machacek, Bohuslav Casensky
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Patent number: 4186252Abstract: A method for preparing vitamin B.sub.1 in a fermentation process involves cultivating mutants of yeast of the genus Saccharomyces Meyen emend Reess that synthesize this vitamin from sugars and inorganic salts and excrete it from living cells into fermentation media.Type: GrantFiled: May 2, 1977Date of Patent: January 29, 1980Assignee: Vysoka skola chemicko-technologickaInventor: Ludmila Silhankova
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Patent number: 4177295Abstract: A method for treating beverages containing turbidity procursors and/or enzymes is described. The technique involves contacting the beverages with a diol or dicarboxylic acid polycondensate at a temperature ranging from 28.4.degree. to 176.degree. F., thereby resulting in separation of deleterious substance. The colloidal and taste qualities of the resultant beverages is thereby enhanced.Type: GrantFiled: April 20, 1978Date of Patent: December 4, 1979Assignee: Vysoka skola chemicko-technologickaInventors: Vladimir Kubanek, Gabriela Basarova, Jaroslav Kralicek, Josef Skach, Zdenek Fencl, Jiri Budin, Jaroslava Kondelikova, Eduard Sittler