Abstract: This invention relates to a Nanostructured Lipid Carrier (NLC) particle comprising a therapeutic agent encapsulated therein for ocular delivery of the therapeutic agent, wherein the Nanostructured Lipid Carrier comprises: (i) a solid outer shell comprising a solid lipid, and (ii) a liquid core comprising a liquid lipid; and wherein the core comprises the therapeutic agent. Compositions of the NLC particles, use of the NLC particles, methods of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.

Abstract: This invention relates to a Nanostructured Lipid Carrier (NLC) particle comprising a therapeutic agent encapsulated therein for ocular delivery of the therapeutic agent, wherein the Nanostructured Lipid Carrier comprises: (i) a solid outer shell comprising a solid lipid, and (ii) a liquid core comprising a liquid lipid; and wherein the core comprises the therapeutic agent. Compositions of the NLC particles, use of the NLC particles, methods of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.

Abstract: This invention relates to a composition for ophthalmic delivery of a therapeutic agent, the composition comprising an oil-in-water (o/w) microemulsion comprising a fatty acid, or fatty acid ester, as the oil phase; an aqueous phase; a surfactant; and a co-surfactant, and wherein the composition further comprise a suspension of therapeutic agent-loaded nanoparticles. Use of the composition for the treatment or prevention of an eye disorder, a method of treatment or prevention of an eye disorder and an eye drop dispenser are also provided.

Abstract: A method of implementing calls includes identifying a call scheduled for a time in the future from an electronic calendar associated with a user and prior to the call, ordering a plurality of codecs used by an Internet Protocol (IP) phone of the user for the scheduled call. The method further includes, during the call and using a processor, calculating a mean opinion score for the call and storing the mean opinion score as part of call data for the call within a data storage device comprising historical call data.

Abstract: The present disclosure teaches an antenna structure comprising an antenna transmitting a signal in the terahertz band and at least one mirror, which is moveable to reflect a terahertz-band signal from a neighboring antenna. There may be a communication cell comprising a plurality of such antenna structures. The communication cell may define a coverage area. In another embodiment, the present disclosure teaches a method for controlling the antenna structures to improve the performance of the communication cell.

Abstract: A method of implementing calls includes identifying a call scheduled for a time in the future from an electronic calendar associated with a user and prior to the call, ordering a plurality of codecs used by an Internet Protocol (IP) phone of the user for the scheduled call. The method further includes, during the call and using a processor, calculating a mean opinion score for the call and storing the mean opinion score as part of call data for the call within a data storage device comprising historical call data.

Abstract: A method of implementing calls includes identifying a call scheduled for a time in the future from an electronic calendar associated with a user and prior to the call, ordering a plurality of codecs used by an Internet Protocol (IP) phone of the user for the scheduled call. The method further includes, during the call and using a processor, calculating a mean opinion score for the call and storing the mean opinion score as part of call data for the call within a data storage device comprising historical call data.

Abstract: Codec selection and usage for calls includes identifying a call scheduled for a time in the future from an electronic calendar associated with a user and prior to the call, ordering a plurality of codecs used by an Internet Protocol (IP) phone of the user for the scheduled call. During the call and using a processor, a mean opinion score for the call is calculated and stored as part of call data for the call within a data storage device including historical call data.

Abstract: A method of implementing calls includes identifying a call scheduled for a time in the future from an electronic calendar associated with a user and prior to the call, ordering a plurality of codecs used by an Internet Protocol (IP) phone of the user for the scheduled call. The method further includes, during the call and using a processor, calculating a mean opinion score for the call and storing the mean opinion score as part of call data for the call within a data storage device comprising historical call data.

Abstract: A method for modelling a relationship between effective bandwidth coefficient (EBC) and mean throughput in a network includes: calculating an EBC for each sample packet trace of a specified traffic type, where the EBC is the ratio of the estimated effective bandwidth EB to mean traffic flow rate M of the sample packet trace; storing the EBC for each sample packet trace with the associated value of M; and modelling EBC versus M for a plurality of values of M for the specified traffic type. Calculating the EBC includes: setting a maximum packet delay target parameter and a violation target parameter for a specified traffic type; collecting a sample packet trace of the specified traffic type from a selected measurement point on the network; estimating the EB of the sample packet trace using the maximum packet delay target parameter and a violation target parameter; and calculating the EBC for the sample packet trace as EBC=EB/M.

Abstract: The invention provides water removal and storage system adapted for use in a building structure, said system comprising a water storage vessel for the removal and storage of water from one or more supply lines and resupply of water stored on demand. The system of the invention provides either a solution to the problems of flooding due to pipe rupture, interrupted water supply due to freezing, pipe rupture due to freezing, and water damage due to uncontrolled thaw. In one aspect the invention provides a controller adapted to receive control signals remotely, said signals control the valve to regulate the water supply pressure and/or flow rate to a desired set point.

Abstract: A method of implementing calls includes identifying a call scheduled for a time in the future from an electronic calendar associated with a user and prior to the call, ordering a plurality of codecs used by an Internet Protocol (IP) phone of the user for the scheduled call. The method further includes, during the call and using a processor, calculating a mean opinion score for the call and storing the mean opinion score as part of call data for the call within a data storage device comprising historical call data.

Abstract: Codec selection and usage for calls includes identifying a call scheduled for a time in the future from an electronic calendar associated with a user and prior to the call, ordering a plurality of codecs used by an Internet Protocol (IP) phone of the user for the scheduled call. During the call and using a processor, a mean opinion score for the call is calculated and stored as part of call data for the call within a data storage device including historical call data.

Abstract: A method for performing a multi-stage dilation of optical fibers is described, the method comprising performing successive dilation steps such that the adiabatic condition is maintained throughout the fiber. There is also described various optical devices employing such multi-stage dilated optical fibers, as well as methods of manufacture of the optical devices.

Abstract: A waveguide spectrum analyser comprises an input waveguide (10) for receiving a beam of electromagnetic radiation to be spectrally analysed, a plurality of output waveguides (14, 16) which are single mode for wavelengths longer than a certain minimum, a substantially wavelength independent splitter (18) for splitting the input radiation between the single-mode output waveguides, and an array (24) of radiation-sensitive detector elements (30). Each output waveguide has a respective exit port (20, 22) facing the detector array so that radiation from the exit port is diffracted onto the array. The separation of the exit ports and the distance to the detector array is selected such that at least for a range of wavelengths longer than the certain minimum a plurality of interference fringes are produced at the array each extending across sufficient detector elements to allow spatial sampling of the fringes above the Nyquist rate.

Abstract: An apparatus for interrogating wavelength-specific devices has a broadband optical source to illuminate an interferometer which provides a low coherence temporal interferogram. At least one array of wavelength-specific devices, such as fiber Bragg gratings connected in series with one another, receives the interferogram, so that each device interacts with a limited range of wavelength bandwidth relative to the bandwidth of the broadband optical source. Instead of illuminating an interferometer with the output of an array of devices which have each interacted with a broadband light source at their own characteristic wavelengths, therefore, an interferometer is used to modulate the output from a broadband source to produce a low coherence interferogram. The array of devices then extracts or filters a higher coherence interferogram from this low coherence interferogram.

Abstract: A biosensor includes a light transmissive optical component (18) comprising a plurality of optical fibres fused side-by-side, the fibres extending between and terminating at opposite faces of the component for transmission of light through the component. A gold film (20) is coated on one face of the optical component, and a plurality of nanohole arrays are formed in the gold film.

Abstract: A method for performing a multi-stage dilation of optical fibres is described, the method comprising performing successive dilation steps such that the adiabatic condition is maintained throughout the fibre. There is also described various optical devices employing such multi-stage dilated optical fibres, as well as methods of manufacture of the optical devices.

Abstract: The invention provides simultaneous suppression of PMD and PDG in a fiber Raman amplifier. One embodiment employs a two-section fiber with one section being unspun and the other, longer, section having a periodic spin profile. The other embodiment employs a single segment fiber having a periodic exponentially varying spin profile.