Abstract: Disclosed are topical composition for delivery of an active agent to keratinous tissue, comprising a low molecular weight chitosan that is covalently modified chitosan with octane sulfonic acid which are attached to the chitosan via sulfonamide linkages (OsC), an effective amount of an active agent, and a carrier, and wherein the chitosan has a molecular weight of about 50 kD to about 150 kD. Also disclosed are methods of making the compositions and methods of using the compositions that entail topical application.
Type:
Grant
Filed:
January 7, 2020
Date of Patent:
May 31, 2022
Assignees:
Alumend, LLC, WavePharma, LLC
Inventors:
Ronald E. Utecht, Rachel Gyasi, Miri Seiberg
Abstract: Compositions are described that contain treated chitosan, modified chitosan and/or modified and treated chitosan for use in formulations for skin, hair and nails, and in compositions and methods of reducing topical agent-induced skin irritation and inflammation.
Type:
Grant
Filed:
December 13, 2018
Date of Patent:
October 5, 2021
Assignees:
Alumend, LLC, Wavepharma, LLC
Inventors:
Ronald E. Utecht, Therese M. Downey, Miri Seiberg, Stanley S. Shapiro, Jack V. Foster, Jr.
Abstract: Compositions are described that contain treated chitosan, modified chitosan and/or modified and treated chitosan for use in formulations for skin, hair and nails, and in compositions and methods of reducing topical agent-induced skin irritation and inflammation.
Type:
Grant
Filed:
December 13, 2018
Date of Patent:
September 21, 2021
Assignees:
Alumend, LLC, Wavepharma, LLC
Inventors:
Ronald E. Utecht, Therese M. Downey, Miri Seiberg, Stanley S. Shapiro, Jack V. Foster, Jr.
Abstract: Disclosed are topical composition for delivery of an active agent to keratinous tissue, comprising a low molecular weight chitosan that is covalently modified chitosan with octane sulfonic acid which are attached to the chitosan via sulfonamide linkages (OsC), an effective amount of an active agent, and a carrier, and wherein the chitosan has a molecular weight of about 50 kD to about 150 kD. Also disclosed are methods of making the compositions and methods of using the compositions that entail topical application.
Type:
Application
Filed:
January 7, 2020
Publication date:
September 10, 2020
Applicants:
Alumend, LLC, WAVEPHARMA, LLC
Inventors:
Ronald E. Utecht, Rachel Gyasi, Miri Seiberg
Abstract: Compositions are described that contain treated chitosan, modified chitosan and/or modified and treated chitosan for use in formulations for skin, hair and nails, and in compositions and methods of reducing topical agent-induced skin irritation and inflammation.
Type:
Application
Filed:
December 13, 2018
Publication date:
June 20, 2019
Applicants:
Alumend, LLC, WAVEPHARMA, LLC
Inventors:
Ronald E. Utecht, Therese M. Downey, Miri Seiberg, Stanley S. Shapiro, Jack V. Foster, JR.
Abstract: Compositions are described that contain treated chitosan, modified chitosan and/or modified and treated chitosan for use in formulations for skin, hair and nails, and in compositions and methods of reducing topical agent-induced skin irritation and inflammation.
Type:
Application
Filed:
December 13, 2018
Publication date:
May 2, 2019
Applicants:
Alumend, LLC, WAVEPHARMA, LLC
Inventors:
Ronald E. Utecht, Therese M. Downey, Miri Seiberg, Stanley S. Shapiro, Jack V. Foster, JR.
Abstract: Compositions are described that contain treated chitosan, modified chitosan and/or modified and treated chitosan for use in formulations for skin, hair and nails, and in compositions and methods of reducing topical agent-induced skin irritation and inflammation.
Type:
Grant
Filed:
June 12, 2017
Date of Patent:
April 16, 2019
Assignees:
Alumend, LLC, Wavepharma, LLC
Inventors:
Ronald E. Utecht, Therese M. Downey, Miri Seiberg, Stanley S. Shapiro, Jack V. Foster
Abstract: Compositions are described that contain treated chitosan, modified chitosan and/or modified and treated chitosan for use in formulations for skin, hair and nails, and in compositions and methods of reducing topical agent-induced skin irritation and inflammation.
Type:
Grant
Filed:
December 4, 2017
Date of Patent:
April 2, 2019
Assignees:
ALUMEND, LLC, WAVEPHARMA, LLC
Inventors:
Ronald E. Utecht, Therese M. Downey, Miri Seiberg, Stanley S. Shapiro, Jack V. Foster, Jr.
Abstract: Compositions are described that contain treated chitosan, modified chitosan and/or modified and treated chitosan for use in formulations for skin, hair and nails, and in compositions and methods of reducing topical agent-induced skin irritation and inflammation.
Type:
Application
Filed:
December 4, 2017
Publication date:
April 5, 2018
Applicants:
Alumend, LLC, WavePharma, LLC
Inventors:
Ronald E. Utecht, Therese M. Downey, Miri Seiberg, Stanley S. Shapiro, Jack V. Foster, JR.
Abstract: Compositions are described that contain treated chitosan, modified chitosan and/or modified and treated chitosan for use in formulations for skin, hair and nails, and in compositions and methods of reducing topical agent-induced skin irritation and inflammation.
Type:
Grant
Filed:
December 21, 2016
Date of Patent:
December 5, 2017
Assignees:
Alumend, LLC, WavePharma, LLC
Inventors:
Ronald E. Utecht, Therese M. Downey, Miri Seiberg, Stanley S. Shapiro