Abstract: In one aspect, the present invention provides compounds having formula I or IV as shown below: as further defined herein. In additional aspects, the present invention provides compositions and kits comprising the compounds of the invention and methods for their use, for example, for the prevention or treatment of a cancer.
Type:
Grant
Filed:
April 29, 2005
Date of Patent:
April 1, 2008
Assignees:
Wellgen, Inc., The Regents of the University of Minnesota, Rutgers, the State University of New Jersey
Inventors:
Chi-Tang Ho, Naisheng Bai, Zigang Dong, Ann M. Bode, Slavik Dushenkov
Abstract: The present invention provides novel benzotropolone derivatives represented by the general formula: including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective antioxidant and anti-inflammatory agents. The present invention also provides novel method of synthesizing benzotropolone compounds in high yields and method of treating inflammatory conditions using benzotropolone containing compounds.
Type:
Grant
Filed:
June 23, 2006
Date of Patent:
October 30, 2007
Assignees:
Wellgen, Inc., Rutgers, The State University of New Jersey
Inventors:
Chi-Tang Ho, Geetha Ghai, Shengmin Sang, Jin-Woo Jhoo, Mou-Tuan Huang, Robert T. Rosen, Slavik Dushenkov