Abstract: The present invention provides a compound with a general formula (I) or a salt thereof, wherein, R1 and R2, are, independently of each other, F or CnF2n+1 with n=1-10, and R3 and R4 are, independently of each other, C1-C10-alkyl.

Abstract: The invention provides a method of assessing the risk of occurrence of progressive multifocal leukoencephalopathy (PML) in a subject as well as a method of stratifying a subject undergoing VLA-4 blocking agent treatment for suspension of VLA-4 blocking agent treatment. These methods comprise detecting the level of L-selectin (CD62L) and optionally LFA-1 expressing T cells in a sample from the subject.

Abstract: The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.

Abstract: The invention relates to platinum complexes and their use in biomedical applications, like in vitro and in vivo imaging and cell staining. The present invention provides new materials and their use as imaging agent. The formation of luminescent aggregates can allow a switch of the emission leading to a dynamic label and on the formation of soft assemblies, which, in some cases, are even more emissive than the isolated corresponding species.

Abstract: The present invention is related to an electrochemical processor, which comprises two electrodes of different electrochemical potential, which are bridged via an electrolyte. Upon, completion of the electric circuit between the two electrodes, the second electrode is oxidized and therefore changed in at least one physical parameter, e.g. the second electrode becomes transparent. The electrochemical processor is characterized in that the surface of the second electrode, which is in contact with the electrolyte, is partially covered with an electrically insulating material, wherein this material is adjacent to the electrolyte. Moreover, the present invention relates to the use of this electrochemical processor and a method of composing such electrochemical processor.

Abstract: A method of synthesizing Pyrazoles by means of the oxidative conversion of Enamines with suitable N-containing carboxylic acid derivatives in the presence of copper ions and 2-picolinic acid derivatives is provided.

Abstract: The present invention relates to the use of Yersinia outer protein M (YopM)in the prevention and/or treatment of psoriasis by cutaneous, intradermalor subcutaneous administration. In particular, the present invention relates to the use of YopM in the treatment of plaque psoriasis, guttate psoriasis, inverse psoriasis, pustular psoriasis, erythrodermic psoriasis, arthritis psoriasis.

Abstract: The present invention is directed to a method for determining nuclear DNA (nDNA) in sperm sample by means of Raman micro-spectroscopy. In particular, the method is useful to determine the presence of intact and/or damaged nDNA in a sperm. Further, the present invention is directed to a method for screening sperm for in vitro fertilization or artificial reproduction treatment (ART).

Abstract: The present invention is related to the tripeptide (I)Lys-(d)Pro-(I)Thr (KdPT) or pharmaceutically acceptable salts thereof for therapeutic, prophylactic therapeutic or cosmetic treatment of a disease with increased apoptosis, wherein the treatment has an anti-apoptotic effect. The present invention is also related to the use of KdPT or pharmaceutically acceptable salts thereof for the manufacture of a pharmaceutical or cosmetic composition for an anti-apoptotic treatment of disorders that are related with increased apoptosis.

Abstract: The present subject matter can include a two-dimensional electrochemical writing assembly and uses thereof. The writing assembly can enable for time-dependently displaying of a physical parameter, such as a time-dependent display or recording of the temperature. The writing assembly comprises two different types of electrochemical processors, of which one type is used for controlling the time-dependent switching of the second type of electrochemical processors used in the writing assembly.

Abstract: The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P receptors, in particular, in diseases which are connected to the regulatory function of sphingosine-1-phosphate (S1P) and its analogues, such as inflammation, pain, autoimmune diseases and cardiovascular diseases.

Abstract: The invention relates to platinum complexes and their use in biomedical applications, like in vitro and in vivo imaging and cell staining. The present invention provides new materials and their use as imaging agent.

Abstract: The invention is about E. coli host cells which are capable to convert glycerol to serinol. Furthermore, a process for producing serinol is disclosed, which comprises culturing E. coli host cells inactive for triosephosphate isomerase and active for dihydroxyacetone phosphate aminotransferase to convert glycerol to serinol, induction of conversion from glycerol to serinol by adding at least glycerol to the cell culture, and isolating serinol from the cell culture.

Abstract: A method of synthesizing Pyrazoles by means of the oxidative conversion of Enamines with suitable N-containing carboxylic acid derivatives in the presence of copper ions and 2-picolinic acid derivatives is provided.

Abstract: The present invention relates to a pharmaceutical composition comprising glucocorticoid (GC)-induced human monocytes, and optionally a pharmaceutically acceptable carrier.

Abstract: The present invention is related to an electrochemical processor, which comprises two electrodes of different electrochemical potential, which are bridged via an electrolyte. Upon, completion of the electric circuit between the two electrodes, the second electrode is oxidized and therefore changed in at least one physical parameter, e.g. the second electrode becomes transparent. The electrochemical processor is characterized in that the surface of the second electrode, which is in contact with the electrolyte, is partially covered with an electrically insulating material, wherein this material is adjacent to the electrolyte. Moreover, the present invention relates to the use of this electrochemical processor and a method of composing such electrochemical processor.

Abstract: The invention describes a novel process for synthesizing pyrazoles by means of oxidative conversion of enamines with suitable N-containing carboxylic acid derivatives.

Abstract: Method for providing a hypoallergenic glycoprotein includes growing at least one of a mutated plant, a part of the mutated plant, plant cells produced from the mutated plant, a transgenic plant, a part of the transgenic plant and plant cells produced from the transgenic plant wherein an activity of an enzyme Golgi ?-mannosidase II has been eliminated or decreased so as to obtain a grown material. The hypoallergenic glycoprotein is isolated from the grown material.

Abstract: The invention relates to an adaptive optical device for the reflection of impinging radiation, the adaptive optical device comprising at least one actuator and at least one partially reflective volume. The at least one partially reflective volume has a first surface that is oriented to the impinging radiation. The at least one partially reflective volume is at least partially deformable by said at least one actuator such that the impinging radiation is reflected at the at least one partially reflective volume substantially in accordance with Bragg's law. Further, the invention relates to a method and apparatus for controlling the shape of an adaptive optical device.

Abstract: A method for producing an eukaryotic organism having at least one of enhanced pathogen resistance and resistance to stress includes expressing in a cytosol of the eukaryotic organism a glucose-6-phosphate dehydrogenase with an increased NADPH tolerance compared to an endogenous cytosolic glucose-6-phosphate dehydrogenase and at least one of reducing, eliminating and suppressing an activity of the endogenous cytosolic glucose-6-phosphate dehydrogenase.