Patents Assigned to Wex Medical Instrumentation Co., Ltd.
  • Analgesic composition and method
    Publication number: 20040214842
    Abstract: A pharmaceutical analgesic composition comprising an opioid analgesic agent and a compound that binds to the SS1 or SS2 subunit of a sodium channel, such as tetrodotoxin and saxitoxin, and analogs thereof. Administration of an opioid analgesic agent and a compound that binds to the SS1 or SS2 subunit of a sodium channel, such as tetrodotoxin and saxitoxin, and analogs thereof, produces analgesia in the treatment of pain in mammals.
    Type: Application
    Filed: May 20, 2004
    Publication date: October 28, 2004
    Applicant: Wex Medical Instrumentation Co., Ltd.
    Inventors: Baoshan Ku, Frank Hay Kong Shum
  • Analgesic composition and method
    Patent number: 6780866
    Abstract: A pharmaceutical analgesic composition comprising an opioid analgesic agent and a compound that binds to the SS1 or SS2 subunit of a sodium channel, such as tetrodotoxin and saxitoxin, and analogs thereof. Administration of an opioid analgesic agent and a compound that binds to the SS1 or SS2 subunit of a sodium channel, such as tetrodotoxin and saxitoxin, and analogs thereof, produces analgesia in the treatment of pain in mammals.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: August 24, 2004
    Assignee: WEX Medical Instrumentation Co., Ltd.
    Inventors: Baoshan Ku, Frank Hay Kong Shum
  • Method of local anesthesia and analgesia
    Patent number: 6599906
    Abstract: The present invention provides a method of producing local analgesia and anesthesia in a mammal experiencing pain in a nerve tissue region. The method includes topically administrating to the region, in a suitable pharmaceutical vehicle, an effective dose of a sodium channel blocking compound.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: July 29, 2003
    Assignee: Wex Medical Instrumentation Co., Ltd.
    Inventors: Baoshan Ku, Shiquan Qi
  • Method of extracting tetrodotoxin
    Patent number: 6552191
    Abstract: The present invention relates to a new process of extracting tetrodotoxin from the tissues of an organism. The invention provides increased yield of tetrodotoxin from animal tissues. In the invention, a lixiviated solution is obtained by soaking the tissues with water and a weak organic acid. Soluble proteins are removed by heating the lixiviated solution at a temperature below the boiling point. After pH adjustment, the solution is passed through a cation exchange column. Inorganic salts and alkaline amino acids are removed, and then the tetrodotoxin is adsorbed and eluted from activated carbon. The tetrodotoxin is crystallized by adjusting the pH to 8-10.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: April 22, 2003
    Assignee: Wex Medical Instrumentation Co., Ltd.
    Inventors: Maoqing Zhou, Frank Hay Kong Shum
  • Method of analgesia
    Patent number: 6407088
    Abstract: This invention relates to a method of producing analgesia in a mammal experiencing pain by systemically administering an effective amount of a composition comprising essentially of a sodium channel blocking compound, in a suitable pharmaceutical vehicle, to alleviate the pain.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: June 18, 2002
    Assignee: Wex Medical Instrumentation Co., Ltd.
    Inventors: Qingbin Dong, Frank Hay Kong Shum