Patents Assigned to Wolf-Georg Forssmann
  • Cadherin derived growth factor and its use
    Patent number: 6809175
    Abstract: A peptide referred to as cadherin-derived growth factor (CDGF) the sequence of which corresponds to a partial sequence of a pre-pro-cadherin, said pre-pro-cadherin comprising the domains signal sequence, pro sequence cadherin repeats, transmembrane region and intracellular domain, characterized in that the sequence of said peptide comprises the pro sequence, that at least one of the other domains of the pre-pro-cadherin is lacking, and that said peptide has cell-proliferative, cell-protective and/or cell-differential properties.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: October 26, 2004
    Assignee: Prof. Dr. Wolf-Georg Forssmann
    Inventors: Wolf-Georg Forssmann, Ludger Standker, Markus Meyer, Hossein Mostafavi, Hans-Georg Opitz, Lothar Kling
  • Use of phosphordiesterase inhibitors in the treatment of prostatic diseases
    Publication number: 20030199517
    Abstract: The present invention pertains to the use of inhibitors of phosphodiesterase I, IV and V for the prophylaxis and treatment of prostatic diseases, in particular the use of
    Type: Application
    Filed: May 23, 2003
    Publication date: October 23, 2003
    Applicant: Wolf-Georg Forssmann
    Inventors: Wolf-Georg Forssmann, Christian Georg Steif, Michael Carsten Truss, Stefan Uckert, Udo Jonas
  • Inhibitors of phosphodiesterase IV for x-ray imaging
    Patent number: 6083483
    Abstract: The invention relates to the use of inhibitors of phosphodiesterase IV for the modulation of the motility and peristalsis of the hollow organs of the urogenital and gastrointestinal tract.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: July 4, 2000
    Assignee: Wolf-Georg Forssmann
    Inventors: Christian Stief, Torsten Strohmeyer, Wolf-Georg Forssmann, Markus Meyer, Peter Schulz-Knappe, Akmal Taher
  • Use of inhibitors of phosphodiesterase IV
    Patent number: 5891904
    Abstract: The invention relates to the use of inhibitors of phosphodiesterase IV for the modulation of the motility and peristalsis of the hollow organs of the urogenital and gastrointestinal tract.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: April 6, 1999
    Assignee: Wolf-Georg Forssmann
    Inventors: Christian Stief, Torsten Strohmeyer, Wolf-Georg Forssmann, Markus Meyer, Peter Schulz-Knappe, Akmal Taher
  • Phosphorylated derivatives of cardiodilatin/ANF peptides
    Patent number: 5461142
    Abstract: Described are derivatives of the precursor peptide of the cardiodilatin/atrial sodiuretic factor (CDD-ANF) or fragments thereof which comprise at least the amino acid sequence of alpha-hANaP. The derivatives according to the present invention are compounds of the formula (I) ##STR1## X is a phosphate or thiophosphate group. R is NH.sub.2 or a peptide fragment from the amino acid sequence of gamma-hANaP. Radio-labelled derivatives are also possible. A method for the qualitative and/or quantitative determination of peptides containing the sequence of alpha-hANaP and a use of the compounds having the formula (I) as medicaments for various vaso- and renal related disorders are further described.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: October 24, 1995
    Assignees: Pharma Bissendorf Peptide GmbH, Wolf-Georg Forssmann
    Inventors: Wolf-Georg Forssmann, Michael Gagelmann, Dieter Hock
  • Cardiodilatin fragment, process for preparing same and use thereof
    Patent number: 5449751
    Abstract: Described is a peptide fragment which comprises the amino acid sequence 95-126 of ANF/CDD 1-126 (gamma-hANaP) and is formed in the kidney. The fragment urodilatin (ANF/CDD 95-126) has the following amino acid sequence: ##STR1## wherein R.sup.1 and R.sup.2 each represent further peptide fragments of ANF/CDD 1-126 (gamma-hANaP). In the amino acid sequence R.sup.1 is Thr-Alo-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser and R.sup.2 is Asn-Ser-Phe-Arg-Tyr. Further described are processes for the preparation and/or recovery of the new peptide fragment and a medicament containing urodilatin (ANF/CDD 95-126 ) as well as medical indications of the medicament.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: September 12, 1995
    Assignees: Pharma Bissendorf Peptide GmbH, Wolf-Georg Forssmann
    Inventors: Wolf-Georg Forssmann, Jeanette M. Alt, Gerhard Becker, Franz Herbst