Patents Assigned to Woods Hole Oceanographic Institution (W.H.O.I.)
  • Modified apoaequorin having increased bioluminescent activity
    Patent number: 5360728
    Abstract: The present invention encompasses modified apoaequorin nucleotide and amino acid sequences capable of emitting light in the presence of luciferin and a light-triggering cation such as Ca.sup.2+, which possess bioluminescent activity greater than unmodified apoaequorin and methods of use therefore.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: November 1, 1994
    Assignee: Woods Hole Oceanographic Institution (W.H.O.I.)
    Inventor: Douglas Prasher