Abstract: A Mura compensation method and device for a curved screen are disclosed. The method includes: dividing each of curved portions into blocks; acquiring measured luminance values of each of the illuminated sub-pixels in a non-curved portion and measured luminance values of each of the illuminated blocks in the curved portions according to grayscale values, wherein each of measured luminance values has a corresponding relationship with one of the grayscale values; and using the measured luminance values and the grayscale values in a gamma relational expression, solving for coefficients and a gamma value in the gamma relational expression by a fitting process, finding a theoretical luminance value corresponding to each of the grayscale values in a gamma curve according to the gamma value, and using the theoretical luminance value, the coefficients, and the gamma value in the gamma relational expression to solve for a compensation grayscale value.