Abstract: The present invention provides a CD81 and OCLN double transgenic mouse and its construction method and use. The double transgenic mouse can be used to constitute acute and chronic HCV infection in a mouse model.
Type:
Grant
Filed:
June 24, 2014
Date of Patent:
December 6, 2016
Assignee:
Wuhan Institute of Virology, CAS
Inventors:
Hong Tang, Xin-Wen Chen, Ji-Zheng Chen, Yang Zhao, Chao Zhang, Hai-Rong Chen