Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. In some cases, this disclosure provides methods for the generation of polynucleotide barcode libraries, and for the attachment of such polynucleotides to target polynucleotides.

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. In some cases, this disclosure provides methods for the generation of polynucleotide barcode libraries, and for the attachment of such polynucleotides to target polynucleotides.

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.

Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.

Abstract: A controller for protecting data on a data storage medium is disclosed. A single physical data storage device is divided into a protected data space, a virtual data space and an unprotected data space in an installation mode. Subsequently, the protected and unprotected data space are presented as two separate physical data storage devices and the existence of virtual data space is concealed. The two data storage devices are respectively represented as having capacity equal to that of the protected and unprotected data space only. A set of protected data (which may include software and data) is initially installed in the protected data space. During use, data transmitted to the controller for recording in the data storage space is recorded only in the virtual data space. Data may be read from either the protected data space or the virtual data space, depending on whether the virtual data space contains newer data.

Abstract: A factorial experiment is conducted on a manufacturing process to generate a response matrix. The responses are used to calculate individual contrasts in a document as well as replicates effects. The contrast sums are also calculated and displayed in the document. The largest of the contrast sums are identified, and effects associated with those contrast sums are tested for significance using an end count method. The information from the process transformed into “significant effects” information is used to adjust process variables to improve the manufacturing process by avoiding the effect or imparting it to a measurable response of the process.

Abstract: A stent delivery system is comprised of an elongated flexible advancement member which terminates in a tubular tracking member slidable over a guidewire. An inflatable balloon has proximal and distal ends, the proximal end communicating with an inflation channel, and the distal end attaching to the tracking member. The balloon portion is coextensive with but not attached to the advancement member.

Abstract: A balloon dilatation system is comprised of an elongated flexible advancement member which terminates in a tubular tracking member slidable over a guidewire. An inflatable balloon has proximal and distal ends, the proximal end communicating with an inflation channel, and the distal end attaching to the tracking member. The balloon portion is coextensive with but not attached to the advancement member.

Abstract: The present invention related to miniaturized x-ray tubes, that enable radiation treatment by locating the x-ray source within a human body in close vicinity to or inside of the area to be treated with X-rays. Advantageously, the present invention eliminates most of the problems related to the methods based on a radioactive source and offers a method for efficient and controllable radiation treatment.