Patents Assigned to XDX Inc.
  • Patent number: 8148067
    Abstract: The invention presents a method of diagnosing or monitoring the status of systemic lupus erythematosus (SLE) in a subject or patient comprising detecting the expression of all genes of a diagnostic set in the subject or patient wherein the diagnostic set comprises two or more genes having expression correlated with the classification or status of SLE; and diagnosing or monitoring the status of SLE in the subject or patient by applying at least one statistical method to the expression of the genes of the diagnostic set.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: April 3, 2012
    Assignee: Xdx, Inc.
    Inventors: Preeti G. Lal, Gavin E. Williams, Kirk E. Fry, Jingtao Sun, Russell L. Dedrick
  • Patent number: 8110364
    Abstract: Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or systems containing the same are also described.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: February 7, 2012
    Assignee: XDx, Inc.
    Inventors: Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
  • Publication number: 20120010096
    Abstract: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.
    Type: Application
    Filed: June 13, 2011
    Publication date: January 12, 2012
    Applicant: XDx, Inc.
    Inventors: Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly
  • Publication number: 20110306518
    Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
    Type: Application
    Filed: August 22, 2011
    Publication date: December 15, 2011
    Applicant: XDx, Inc.
    Inventors: Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
  • Publication number: 20110262914
    Abstract: Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or systems containing the same are also described.
    Type: Application
    Filed: December 1, 2010
    Publication date: October 27, 2011
    Applicant: XDx, Inc.
    Inventors: Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly
  • Patent number: 7993832
    Abstract: The invention presents methods of using splice variants and reagents thereof for diagnosing and monitoring the status of transplants and immune disorders including diagnosing, monitoring and predicting transplant rejection or non-rejection, steroid responsiveness, and onset or flare of immune disorders.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: August 9, 2011
    Assignee: XDx, Inc.
    Inventors: Steven Rosenberg, Kirk Fry, Bin Wu, Russell L. Dedrick
  • Patent number: 7960121
    Abstract: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: June 14, 2011
    Assignee: XDX, Inc.
    Inventors: Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
  • Publication number: 20110104697
    Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
    Type: Application
    Filed: January 5, 2011
    Publication date: May 5, 2011
    Applicant: XDx, Inc.
    Inventors: Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
  • Publication number: 20110070584
    Abstract: Methods of diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis and kits or systems containing the same are also described.
    Type: Application
    Filed: July 1, 2010
    Publication date: March 24, 2011
    Applicant: XDx, Inc.
    Inventors: Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly
  • Publication number: 20110059449
    Abstract: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.
    Type: Application
    Filed: June 24, 2010
    Publication date: March 10, 2011
    Applicant: XDx, Inc.
    Inventors: JAY WOHLGEMUTH, KIRK FRY, ROBERT WOODWARD, NGOC LY
  • Patent number: 7892745
    Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: February 22, 2011
    Assignee: XDx, Inc.
    Inventors: Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
  • Patent number: 7879556
    Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: February 1, 2011
    Assignee: XDx, Inc.
    Inventors: Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
  • Publication number: 20100317018
    Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
    Type: Application
    Filed: August 12, 2010
    Publication date: December 16, 2010
    Applicant: XDx, Inc.
    Inventors: Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
  • Patent number: 7829286
    Abstract: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: November 9, 2010
    Assignee: XDx, Inc.
    Inventors: Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
  • Patent number: 7785797
    Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: August 31, 2010
    Assignee: XDx, Inc.
    Inventors: Jay Wohlgemuth, Kirk E. Fry, Robert Woodward, Ngoc Ly, James Prentice, Macdonald Morris, Steven Rosenberg
  • Patent number: 7771950
    Abstract: Methods of diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis and kits or systems containing the same are also described.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: August 10, 2010
    Assignee: XDx, Inc.
    Inventors: Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
  • Publication number: 20100151467
    Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
    Type: Application
    Filed: September 8, 2009
    Publication date: June 17, 2010
    Applicant: XDx, Inc.
    Inventors: Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
  • Publication number: 20100136564
    Abstract: The invention relates to methods useful for diagnosing and monitoring the steroid responsiveness of a subject by detecting expression of steroid modulated genes and for predicting transplant rejection and non-rejection.
    Type: Application
    Filed: November 30, 2009
    Publication date: June 3, 2010
    Applicant: XDx, Inc.
    Inventors: Preeti LAL, Steven Rosenberg, Tod M. Klingler
  • Publication number: 20100099098
    Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
    Type: Application
    Filed: August 19, 2009
    Publication date: April 22, 2010
    Applicant: XDX, INC.
    Inventors: Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
  • Publication number: 20100092989
    Abstract: Described herein is a system for monitoring gene expression for diagnosing and monitoring inflammation disorders, and for monitoring gene expression in inflammation disorders in response to a particular drug treatment regimen. This system for detecting nucleic acid expression in a body fluid uses an isolated polynucleotide to detect expression of a nucleic acid comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 5; SEQ ID NO:11; SEQ ID NO:17; and SEQ ID NO: 23. These nucleic acids are differentially expressed in body fluid in an individual with a disease criterion for a disease as listed in Table 1 as compared to an individual without the disease criterion.
    Type: Application
    Filed: December 10, 2009
    Publication date: April 15, 2010
    Applicant: XDx, Inc.
    Inventors: Jay WOHLGEMUTH, Darren Tayama, Dirk Walther, Preeti G. Lal