Abstract: The invention presents a method of diagnosing or monitoring the status of systemic lupus erythematosus (SLE) in a subject or patient comprising detecting the expression of all genes of a diagnostic set in the subject or patient wherein the diagnostic set comprises two or more genes having expression correlated with the classification or status of SLE; and diagnosing or monitoring the status of SLE in the subject or patient by applying at least one statistical method to the expression of the genes of the diagnostic set.
Type:
Grant
Filed:
November 9, 2007
Date of Patent:
April 3, 2012
Assignee:
Xdx, Inc.
Inventors:
Preeti G. Lal, Gavin E. Williams, Kirk E. Fry, Jingtao Sun, Russell L. Dedrick
Abstract: Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or systems containing the same are also described.
Type:
Grant
Filed:
December 1, 2010
Date of Patent:
February 7, 2012
Assignee:
XDx, Inc.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
Abstract: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.
Type:
Application
Filed:
June 13, 2011
Publication date:
January 12, 2012
Applicant:
XDx, Inc.
Inventors:
Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly
Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
Type:
Application
Filed:
August 22, 2011
Publication date:
December 15, 2011
Applicant:
XDx, Inc.
Inventors:
Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
Abstract: Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or systems containing the same are also described.
Type:
Application
Filed:
December 1, 2010
Publication date:
October 27, 2011
Applicant:
XDx, Inc.
Inventors:
Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly
Abstract: The invention presents methods of using splice variants and reagents thereof for diagnosing and monitoring the status of transplants and immune disorders including diagnosing, monitoring and predicting transplant rejection or non-rejection, steroid responsiveness, and onset or flare of immune disorders.
Type:
Grant
Filed:
August 14, 2007
Date of Patent:
August 9, 2011
Assignee:
XDx, Inc.
Inventors:
Steven Rosenberg, Kirk Fry, Bin Wu, Russell L. Dedrick
Abstract: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.
Type:
Grant
Filed:
June 24, 2010
Date of Patent:
June 14, 2011
Assignee:
XDX, Inc.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
Type:
Application
Filed:
January 5, 2011
Publication date:
May 5, 2011
Applicant:
XDx, Inc.
Inventors:
Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
Abstract: Methods of diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis and kits or systems containing the same are also described.
Type:
Application
Filed:
July 1, 2010
Publication date:
March 24, 2011
Applicant:
XDx, Inc.
Inventors:
Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly
Abstract: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.
Type:
Application
Filed:
June 24, 2010
Publication date:
March 10, 2011
Applicant:
XDx, Inc.
Inventors:
JAY WOHLGEMUTH, KIRK FRY, ROBERT WOODWARD, NGOC LY
Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
Type:
Grant
Filed:
September 8, 2009
Date of Patent:
February 22, 2011
Assignee:
XDx, Inc.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
Type:
Grant
Filed:
August 12, 2010
Date of Patent:
February 1, 2011
Assignee:
XDx, Inc.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
Type:
Application
Filed:
August 12, 2010
Publication date:
December 16, 2010
Applicant:
XDx, Inc.
Inventors:
Jay WOHLGEMUTH, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
Abstract: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.
Type:
Grant
Filed:
December 5, 2008
Date of Patent:
November 9, 2010
Assignee:
XDx, Inc.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
Type:
Grant
Filed:
August 19, 2009
Date of Patent:
August 31, 2010
Assignee:
XDx, Inc.
Inventors:
Jay Wohlgemuth, Kirk E. Fry, Robert Woodward, Ngoc Ly, James Prentice, Macdonald Morris, Steven Rosenberg
Abstract: Methods of diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis and kits or systems containing the same are also described.
Type:
Grant
Filed:
September 16, 2009
Date of Patent:
August 10, 2010
Assignee:
XDx, Inc.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly
Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
Type:
Application
Filed:
September 8, 2009
Publication date:
June 17, 2010
Applicant:
XDx, Inc.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
Abstract: The invention relates to methods useful for diagnosing and monitoring the steroid responsiveness of a subject by detecting expression of steroid modulated genes and for predicting transplant rejection and non-rejection.
Type:
Application
Filed:
November 30, 2009
Publication date:
June 3, 2010
Applicant:
XDx, Inc.
Inventors:
Preeti LAL, Steven Rosenberg, Tod M. Klingler
Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
Type:
Application
Filed:
August 19, 2009
Publication date:
April 22, 2010
Applicant:
XDX, INC.
Inventors:
Jay Wohlgemuth, Kirk Fry, Robert Woodward, Ngoc Ly, James Prentice, MacDonald Morris, Steven Rosenberg
Abstract: Described herein is a system for monitoring gene expression for diagnosing and monitoring inflammation disorders, and for monitoring gene expression in inflammation disorders in response to a particular drug treatment regimen. This system for detecting nucleic acid expression in a body fluid uses an isolated polynucleotide to detect expression of a nucleic acid comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 5; SEQ ID NO:11; SEQ ID NO:17; and SEQ ID NO: 23. These nucleic acids are differentially expressed in body fluid in an individual with a disease criterion for a disease as listed in Table 1 as compared to an individual without the disease criterion.
Type:
Application
Filed:
December 10, 2009
Publication date:
April 15, 2010
Applicant:
XDx, Inc.
Inventors:
Jay WOHLGEMUTH, Darren Tayama, Dirk Walther, Preeti G. Lal