Patents Assigned to Xenome, Ltd.
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Publication number: 20110195909Abstract: An isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids: Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys, SEQ ID NO: 3, where Xaa5 and Xaa6 are independently absent or represent any amino acid residue except Cys; or a sequence in which Gly, Tyr, Lys or Leu are subject to conservative amino acid substitution or side chain modification with the proviso that the peptide is not Mr1A, Mr1B, Mar2, CMrV1A, Bn1.5, Mr1.3 or Au1.4; or a salt, ester, amide, prodrug or cyclised derivative thereof.Type: ApplicationFiled: March 18, 2011Publication date: August 11, 2011Applicant: XENOME LTD.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Publication number: 20110172126Abstract: The invention relates to peptide conjugates including at least one turn inducer wherein the turn inducer comprises a 5-7 membered saturated or unsaturated nitrogen containing heterocyclic ring and methods of making the peptides. Libraries of these peptides, methods of making the libraries are also described and methods of screening the libraries for therapeutic activity are also described.Type: ApplicationFiled: September 3, 2009Publication date: July 14, 2011Applicant: XENOME LTDInventor: Andreas Friedrich Brust
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Patent number: 7851444Abstract: An isolated, synthetic or recombinant ?-conotoxin peptide comprising the following sequence of amino acids: Xaa1 Xaa2 Gly Val Cys Cys Gly Tyr Lys Leu Cys His Pro Cys SEQ ID NO. 3 where Xaa1 is a N-terminal Xaa1 is a N-terminal pyroglutamate (pGlu) or D-pyroglutamate (DpGlu) residue; and Xaa2 is Asn or a deletion; or such a sequence in which one or more Cys is replaced with its corresponding D-amino acid and/or one or more amino acid residues other than Cys has undergone a side chain modification, or a salt, ester, amide or prodrug thereof. The invention also relates to pharmaceutical compositions comprising these peptides and the use of these peptides in the prophylaxis or treatment of conditions, such as but not limited to, pain, inflammation, incontinence, cardiovascular conditions and mood disorders.Type: GrantFiled: December 2, 2003Date of Patent: December 14, 2010Assignee: Xenome Ltd.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Publication number: 20090105129Abstract: The present invention relates generally to methods for inducing, promoting or otherwise facilitating pain relief. More particularly, the present invention relates to a synergistic combination of a selective inhibitor of the neuronal norepinephrine transporter and an analgesic agent in the therapeutic management of vertebrate animals, including humans, for producing analgesia or for the prevention or alleviation of pain.Type: ApplicationFiled: June 22, 2007Publication date: April 23, 2009Applicant: XENOME LTDInventor: Richard James Lewis
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Publication number: 20090088389Abstract: An isolated, synthetic or recombinant ?-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids: Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys, SEQ ID NO: 3, where Xaa5 and Xaa6 are independently absent or represent any amino acid residue except Cys; or a sequence in which Gly, Tyr, Lys or Leu are subject to conservative amino acid substitution or side chain modification with the proviso that the peptide is not Mr1A, Mr1B, Mar2, CMrV1A, Bn1.5, Mr1.3 or Au1.4; or a salt, ester, amide, prodrug or cyclised derivative thereof.Type: ApplicationFiled: October 14, 2008Publication date: April 2, 2009Applicant: XENOME LTD.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Patent number: 7507717Abstract: An isolated, synthetic or recombinant X-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids: Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys, SEQ ID NO:3, where Xaa5 and Xaa6 are independently absent or represent any amino acid residue except Cys; or a sequence in which Gly, Tyr, Lys or Leu are subject to conservative amino acid substitution or side chain modification with the proviso that the peptide is not MrIA, MrIB, Mar2, CMrVIA, Bn1.5, Mr1.3 or Au1.4; or a salt, ester, amide, prodrug or cyclised derivative thereof.Type: GrantFiled: December 2, 2003Date of Patent: March 24, 2009Assignee: Xenome Ltd.Inventors: Richard James Lewis, Paul Francis Alewood, Dianne Alewood, Elka Palant
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Patent number: 7368432Abstract: The invention relates to relatively short conotoxin peptides, about 10-20 residues in length as described herein, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. These conotoxin peptides have analgesic activity and are thus useful for treating or preventing pain.Type: GrantFiled: July 19, 2004Date of Patent: May 6, 2008Assignees: Xenome, Ltd., Cognetix, Inc.Inventors: J. Michael McIntosh, Baldomero M. Olivera, Lourdes J. Cruz, Gloria P. Corpuz, Robert M. Jones, James E. Garrett