Patents Assigned to XY, Inc.
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Publication number: 20100249166Abstract: Antimicrobial compositions and methods of using such antimicrobial compositions to provide a reduction in populations of viable microorganisms.Type: ApplicationFiled: September 12, 2008Publication date: September 30, 2010Applicants: XY, INC., CHATA BIOSYSTEMS, INC.Inventors: Edwin Dean Neas, Thomas Boyd Gilligan
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Publication number: 20100216111Abstract: The inventive technology relates to methods and apparatus for reducing protein content in sperm cell extenders and may include one or more of the following features: techniques for reducing protein content in a sperm cell extender; techniques for reducing protein content in a cryoprotectant-containing B fraction of a sperm cell extender; techniques for preparing sperm cell extenders that do not require clarification; techniques for preparing low density gradient sperm cell extenders suitable for centrifugation; techniques for reducing protein content between individual steps in preparing a sperm cell extender, and techniques for establishing novel values of reduced protein content in sperm cell extenders.Type: ApplicationFiled: November 16, 2009Publication date: August 26, 2010Applicant: XY, INC.Inventor: John L. Schenk
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Patent number: 7723116Abstract: A flow cytometry system (1) for sorting haploid cells, specifically irradiatable sperm cells, with an intermittingly punctuated radiation emitter (56). Embodiments include a beam manipulator (21) and even split radiation beams directed to multiple nozzles (5). Differentiation of sperm characteristics with increased resolution may efficiently allow differentiated sperm cells to be separated higher speeds and even into subpopulations having higher purity.Type: GrantFiled: May 25, 2006Date of Patent: May 25, 2010Assignee: XY, Inc.Inventors: Kenneth M. Evans, Thomas B. Gilligan
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Patent number: 7713687Abstract: Devices, compositions, and methods for handling, separating, packaging, and utilization of spermatozoa (1) that can be derived from previously frozen sperm samples collected from a male mammal. Specifically, techniques to uniformity stain (2) spermatozoal DNA even when derived from previously frozen sperm and separation techniques to separate and isolate spermatozoa even when derived from previously frozen sperm samples into X-chromosome bearing and Y-chromosome bearing populations having high purity.Type: GrantFiled: November 29, 2001Date of Patent: May 11, 2010Assignee: XY, Inc.Inventors: George E. Seidel, Kehuan Lu, Tae Kwang Suh, David G. Cran
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Publication number: 20100007880Abstract: Various optical apparatus, in particular embodiments, may provide a source of parallel light (7, 75). The parallel light (7, 75) may be generally achieved by directing an incident beam at the apex of a prism (1, 22, 24, 26, 28). The prism may have varying configurations. One configuration has a forward conical face (24). Another configuration has a pyramidal forward end (22). Other configurations are also disclosed. Various optical methods and methods for flow cytometry are also disclosed.Type: ApplicationFiled: September 8, 2009Publication date: January 14, 2010Applicant: XY, INC.Inventors: Jonathan Sharpe, Peter Niven Schaare
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Patent number: 7629113Abstract: Improved insemination systems particularly adapted to use for sex-selected sperm sorting include systems which achieve superovulation and then multiple embryo production with sexed embryos. These systems combine with other techniques, including techniques for enhanced sheath fluid and other strategies which minimize stress on the sperm cells, and, potentially, a 2.9 percent sodium citrate sheath solution for bovine species and a hepes bovine gamete media for equine species. Improved collection systems and techniques for the process are described so that commercial application of sperms samples as well as the resulting animals may be achieved.Type: GrantFiled: February 20, 2002Date of Patent: December 8, 2009Assignee: XY, IncInventors: George Seidel, Lisa Herickhoff, John Schenk
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Patent number: 7618770Abstract: The inventive technology relates to methods and apparatus for reducing protein content in sperm cell extenders and may include one or more of the following features: techniques for reducing protein content in a sperm cell extender; techniques for reducing protein content in a cryoprotectant-containing B fraction of a sperm cell extender; techniques for preparing sperm cell extenders that do not require clarification; techniques for preparing low density gradient sperm cell extenders suitable for centrifugation; techniques for reducing protein content between individual steps in preparing a sperm cell extender, and techniques for establishing novel values of reduced protein content in sperm cell extenders.Type: GrantFiled: September 2, 2005Date of Patent: November 17, 2009Assignee: XY, Inc.Inventor: John L. Schenk
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Patent number: 7586604Abstract: Various optical apparatus, in particular embodiments, may provide a source of parallel light (7, 75). The parallel light (7, 75) may be generally achieved by directing an incident beam at the apex of a prism (1, 22, 24, 26, 28). The prism may have varying configurations. One configuration has a forward conical face (24). Another configuration has a pyramidal forward end (22). Other configurations are also disclosed. Various optical methods and methods for flow cytometry are also disclosed.Type: GrantFiled: May 22, 2007Date of Patent: September 8, 2009Assignee: XY, Inc.Inventors: Jonathan C. Sharpe, Peter N. Schaare
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Publication number: 20090054529Abstract: Compositions (3) and methods of using such compositions (3) to condition, clean, or disinfect the flow path of a conduit (8) of a microfluidic devices (16), such as flow cytometers or liquid chromatographs.Type: ApplicationFiled: April 6, 2006Publication date: February 26, 2009Applicants: XY, Inc., Chata Biosytems, Inc.Inventors: Edwin Dean Neas, Thomas Boyd Gilligan
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Publication number: 20080233635Abstract: Isolated non-naturally occurring populations of spermatozoa (15) having high purity and technologies to differentiate spermatozoa (28) based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and apparatus such as beam shaping optics (30) and detectors (32).Type: ApplicationFiled: May 1, 2008Publication date: September 25, 2008Applicant: XY, INC.Inventors: Kenneth M. Evans, Erik B. van Munster
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Patent number: 7371517Abstract: Isolated non-naturally occurring populations of spermatozoa (15) having high purity and technologies to differentiate spermatozoa (28) based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and apparatus such as beam shaping optics (30) and detectors (32).Type: GrantFiled: May 9, 2001Date of Patent: May 13, 2008Assignee: XY, Inc.Inventors: Kenneth M. Evans, Erik B. van Munster
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Publication number: 20070285662Abstract: Various optical apparatus, in particular embodiments, may provide a source of parallel light (7, 75). The parallel light (7, 75) may be generally achieved by directing an incident beam at the apex of a prism (1, 22, 24, 26, 28). The prism may have varying configurations. One configuration has a forward conical face (24). Another configuration has a pyramidal forward end (22). Other configurations are also disclosed. Various optical methods and methods for flow cytometry are also disclosed.Type: ApplicationFiled: May 22, 2007Publication date: December 13, 2007Applicant: XY, Inc.Inventors: Jonathan Sharpe, Peter Schaare
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Publication number: 20070143868Abstract: Semen and sperm cell processing and preservation systems, and methods of producing a mammal and methods of producing mammalian embryos are disclosed. The present invention is directed to sperm cell preservation, fertilization, and insemination, maintaining or enhancing sperm quality and addressing one or more sperm cell characteristics, such as viability, motility, functionality, fertilization rates, and pregnancy rates. Further, sperm cell characteristics may be addressed within the context of various collection, handling, separation, storage, transportation, usage, fertilization, or insemination techniques.Type: ApplicationFiled: January 29, 2007Publication date: June 21, 2007Applicant: XY, Inc.Inventors: William Maxwell, Fiona Hollinshead, Justine O'Brien, Gareth Evans
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Publication number: 20070117086Abstract: A flow cytometry system (1) for sorting haploid cells, specifically irradiatable sperm cells, with an intermittingly punctuated radiation emitter (56). Embodiments include a beam manipulator (21) and even split radiation beams directed to multiple nozzles (5). Differentiation of sperm characteristics with increased resolution may efficiently allow differentiated sperm cells to be separated higher speeds and even into subpopulations having higher purity.Type: ApplicationFiled: May 25, 2006Publication date: May 24, 2007Applicant: XY, Inc.Inventors: Kenneth Evans, Thomas Gilligan
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Patent number: 7221453Abstract: Various optical apparatus provide a source of parallel light (7, 75). The parallel light (7, 75) is generally achieved by directing an incident beam at the apex of a prism (1, 22, 24, 26, 28). The prism may have varying configurations. One configuration has a forward conical face (24). Another configuration has a pyramidal forward end (22). Other configurations are also disclosed. The application also discloses the use of reflectors (20, 78, 216, 316, 400) having internal reflective surfaces shaped as three-dimensional figures of revolution, for example paraboloid or ellipsoid. The reflectors (20, 78, 216, 316) focus light incident onto the reflectors at one or more foci (F, 220, 320, 420). The reflectors may be used in combination with the optical apparatus including the prisms (1, 22, 24, 26, 28). The reflectors (20, 78, 216,316) may be used in flow cytometers for focusing light at a sample stream (237, 337) passing through the focus (F, 220, 320, 420) of the reflector (20, 78, 216, 316).Type: GrantFiled: November 16, 2004Date of Patent: May 22, 2007Assignee: XY, Inc.Inventors: Jonathan C. Sharpe, Peter N. Schaare
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Publication number: 20070099260Abstract: Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a 2.9 percent sodium citrate sheath solution for bovine species and a hepes bovine gamete media for equine species. Improved collection systems and techniques for the process are described so that commercial applications of sperms samples as well as the resulting animals may be achieved.Type: ApplicationFiled: December 20, 2006Publication date: May 3, 2007Applicant: XY, Inc.Inventors: George Seidel, Lisa Herickhoff, John Schenk
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Publication number: 20070099171Abstract: The present invention provides a method of cryopreserving sperm that have been selected for a specific characteristic. In a preferred embodiment, the method is employed to freeze sex-selected sperm. Although the cryopreservation method of the invention can be used to freeze sperm selected by any number of selection methods, selection using flow cytometry is preferred. The present invention also provides a frozen sperm sample that has been selected for a particular characteristic, such as sex-type. In preferred embodiments, the frozen sperm sample includes mammalian sperm, such as, for example, human, bovine, equine, porcine, ovine, elk, or bison sperm. The frozen selected sperm sample can be used in a variety of applications. In particular, the sample can be thawed and used for fertilization. Accordingly, the invention also includes a method of using the frozen selected sperm sample for artificial insemination or in vitro fertilization.Type: ApplicationFiled: December 7, 2006Publication date: May 3, 2007Applicant: XY, Inc.Inventor: John Schenk
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Publication number: 20070092860Abstract: The present invention provides a method of cryopreserving sperm that have been selected for a specific characteristic. In a preferred embodiment, the method is employed to freeze sex-selected sperm. Although the cryopreservation method of the invention can be used to freeze sperm selected by any number of selection methods, selection using flow cytometry is preferred. The present invention also provides a frozen sperm sample that has been selected for a particular characteristic, such as sex-type. In preferred embodiments, the frozen sperm sample includes mammalian sperm, such as, for example, human, bovine, equine, porcine, ovine, elk, or bison sperm. The frozen selected sperm sample can be used in a variety of applications. In particular, the sample can be thawed and used for fertilization. Accordingly, the invention also includes a method of using the frozen selected sperm sample for artificial insemination or in vitro fertilization.Type: ApplicationFiled: December 7, 2006Publication date: April 26, 2007Applicant: XY, Inc.Inventor: John Schenk
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Patent number: 7208265Abstract: The present invention provides a method of cryopreserving sperm that have been selected for a specific characteristic. In a preferred embodiment, the method is employed to freeze sex-selected sperm. Although the cryopreservation method of the invention can be used to freeze sperm selected by any number of selection methods, selection using flow cytometry is preferred. The present invention also provides a frozen sperm sample that has been selected for a particular characteristic, such as sex-type. In preferred embodiments, the frozen sperm sample includes mammalian sperm, such as, for example, human, bovine, equine, porcine, ovine, elk, or bison sperm. The frozen selected sperm sample can be used in a variety of applications. In particular, the sample can be thawed and used for fertilization. Accordingly, the invention also includes a method of using the frozen selected sperm sample for artificial insemination or in vitro fertilization.Type: GrantFiled: January 5, 2000Date of Patent: April 24, 2007Assignee: XY, Inc.Inventor: John L. Schenk
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Patent number: 7195920Abstract: Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a 2.9 percent sodium citrate sheath solution for bovine species and a HEPES bovine gamete media for equine species. Improved collection systems and techniques for the process are described so that commercial applications of sperms samples as well as the resulting animals may be achieved.Type: GrantFiled: February 25, 2003Date of Patent: March 27, 2007Assignee: XY, Inc.Inventors: George E. Seidel, Lisa Herickhoff, John L. Schenk