Abstract: A first amount of sperm of a first animal and a second amount of sperm of a second animal of the same species, the first amount of sperm and the second amount of sperm sex-selected sperm of the same sex, useful in the in-vivo or in-vitro fertilization of an egg of a female animal of the same species of animal for the production of sex-selected embryos and sex-selected offspring.
Abstract: Semen and sperm cell processing and preservation systems, and methods of producing a mammal and methods of producing mammalian embryos are disclosed. The present invention is directed to sperm cell preservation, fertilization, and insemination, maintaining or enhancing sperm quality and addressing one or more sperm cell characteristics, such as viability, motility, functionality, fertilization rates, and pregnancy rates. Further, sperm cell characteristics may be addressed within the context of various collection, handling, separation, storage, transportation, usage, fertilization, or insemination techniques.
Type:
Grant
Filed:
February 12, 2013
Date of Patent:
March 1, 2022
Assignee:
XY, LLC
Inventors:
William M. C. Maxwell, Fiona K. Hollinshead, Justine K. O'Brien, Gareth Evans
Abstract: Semen and sperm cell processing and preservation systems, and methods of producing a mammal and methods of producing mammalian embryos are disclosed. The present invention is directed to sperm cell preservation, fertilization, and insemination, maintaining or enhancing sperm quality and addressing one or more sperm cell characteristics, such as viability, motility, functionality, fertilization rates, and pregnancy rates. Further, sperm cell characteristics may be addressed within the context of various collection, handling, separation, storage, transportation, usage, fertilization, or insemination techniques.
Type:
Grant
Filed:
January 29, 2007
Date of Patent:
January 25, 2022
Assignee:
XY, LLC
Inventors:
William M. C. Maxwell, Fiona K. Hollinshead, Justine K. O'Brien, Gareth Evans
Abstract: A first amount of sperm of a first animal and a second amount of sperm of a second animal of the same species, the first amount of sperm and the second amount of sperm sex-selected sperm of the same sex, useful in the in-vivo or in-vitro fertilization of an egg of a female animal of the same species of animal for the production of sex-selected embryos and sex-selected offspring.
Abstract: A first amount of sperm of a first animal and a second amount of sperm of a second animal of the same species, the first amount of sperm and the second amount of sperm sex-selected sperm of the same sex, useful in the in-vivo or in-vitro fertilization of an egg of a female animal of the same species of animal for the production of sex-selected embryos and sex-selected offspring.
Abstract: Isolated non-naturally occurring populations of spermatozoa (15) having high purity and technologies to differentiate spermatozoa (28) based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and apparatus such as beam shaping optics (30) and detectors (32).
Abstract: An IVF system for successfully utilizing spermatozoa separated into X-chromosome bearing and into Y-chromosome bearing population for insemination. The IVF system includes fertilization medium that can shorten the time from insemination to cleavage and a portable incubator for the transportation of maturing oocytes and inseminated oocytes comprising a straw (19) and an incubation element (20) that can be sealed with a cap (22).
Type:
Grant
Filed:
February 7, 2013
Date of Patent:
January 30, 2018
Assignee:
XY, LLC
Inventors:
George E. Seidel, Tae Kwang Suh, Kehuan Lu
Abstract: Compositions (3) and methods of using such compositions (3) to condition, clean, or disinfect the flow path of a conduit (8) of a microfluidic devices (16), such as flow cytometers or liquid chromatographs.
Type:
Grant
Filed:
November 3, 2014
Date of Patent:
September 5, 2017
Assignees:
XY, LLC, CHD Bioscience, Inc.
Inventors:
Edwin Dean Neas, Jerald Edward Kuiken, John Louis Schenk, Thomas Boyd Gilligan
Abstract: A first amount of sperm of a first animal and a second amount of sperm of a second animal of the same species, the first amount of sperm and the second amount of sperm sex-selected sperm of the same sex, useful in the in-vivo or in-vitro fertilization of an egg of a female animal of the same species of animal for the production of sex-selected embryos and sex-selected offspring.
Abstract: Antimicrobial compositions and methods of using such antimicrobial compositions to provide a reduction in populations of viable microorganisms.
Abstract: A first amount of sperm of a first animal and a second amount of sperm of a second animal of the same species, the first amount of sperm and the second amount of sperm sex-selected sperm of the same sex, useful in the in-vivo or in-vitro fertilization of an egg of a female animal of the same species of animal for the production of sex-selected embryos and sex-selected offspring.
Abstract: The present invention generally relates to a method and apparatus for exciting particles, and more specifically relates to analyzers or sorters for exciting fluorescently labeled particles with a multimode diode laser and the optics for making high resolution determinations from the multimode diode laser beam excitation.
Type:
Grant
Filed:
May 11, 2012
Date of Patent:
September 13, 2016
Assignee:
XY, LLC
Inventors:
Johnathan Charles Sharpe, Donald Francis Perrault
Abstract: Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a 2.9 percent sodium citrate sheath solution for bovine species and a hepes bovine gamete media for equine species. Improved collection systems and techniques for the process are described so that commercial applications of sperms samples as well as the resulting animals may be achieved.
Type:
Grant
Filed:
February 11, 2013
Date of Patent:
August 23, 2016
Assignee:
XY, LLC
Inventors:
George E. Seidel, Lisa A. Herickhoff, John L. Schenk
Abstract: Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a 2.9 percent sodium citrate sheath solution for bovine species and a hepes bovine gamete media for equine species. Improved collection systems and techniques for the process are described so that commercial applications of sperms samples as well as the resulting animals may be achieved.
Type:
Grant
Filed:
February 11, 2013
Date of Patent:
June 14, 2016
Assignee:
XY, LLC
Inventors:
George E. Seidel, Lisa A. Herickhoff, John L. Schenk
Abstract: Isolated non-naturally occurring populations of spermatozoa (15) having high purity and technologies to differentiate spermatozoa (28) based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and apparatus such as beam shaping optics (30) and detectors (32).
Abstract: Embodiments relate to a nozzle coupled to a reflector which is oriented to reflect electromagnetic radiation at particles flowing through the nozzle and a method of illuminating a flow of particles with a nozzle coupled to a reflector.
Abstract: A flow cytometer apparatus and method for differentiating X-chromosome bearing sperm and Y-chromosome bearing sperm having differing amounts of a light emission material coupled to nuclear their DNA. The apparatus may include an irradiation source which generates an irradiation beam responsive to the light emission material coupled to stained sperm cells, optics to focus the irradiation beam to a beam pattern having a height about equal to the length of said sperm cells along the longitudinal axis to about three times the length of said sperm cells along the longitudinal axis, and a detector responsive to said light emitted from said light emission material in response to the irradiation beam.