Patents Assigned to Yakurigaku Chuo Kenkyusho
  • Patent number: 5912152
    Abstract: A process for the preparation of ceramide by using erythrocytes as a starting material is disclosed herein. For the purpose of obtaining ceramide at a low cost and in a large amount, ceramide is prepared by means of hydrolysis or enzymolysis of sphingolipid existing in sphingomyelin. According to the preparation process of the present invention, ceramide useful as a moisturizer for human skin can be obtained at a low cost and in a large amount by relying upon erythrocytes as a starting material.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: June 15, 1999
    Assignee: Yakurigaku Chuo Kenkyusho
    Inventors: Susumu Hara, Hidehiko Takahashi, Yumiko Tomiya
  • Patent number: 5503831
    Abstract: A composition having lipase inhibiting activity is prepared by extracting defatted rice germ with water at room temperature. That composition, which is useful in preventing or treating obesity, can be incorporated into food products.
    Type: Grant
    Filed: May 25, 1994
    Date of Patent: April 2, 1996
    Assignee: Yakurigaku Chuo Kenkyusho
    Inventor: Hidehiko Takahashi
  • Patent number: 5334518
    Abstract: Disclosed is a novel process for the production of pyrocomenic acid [3-hydroxy-4(1H)-pyran-4-one and rubiginol [3,5-dihydroxy-4(1H)-pyran-4-one, which are starting materials for synthesis of maltols useful as food spices as well as additives for cosmetics.The chemical reactions possibly taking place in the fermentation and the heating post-treatment thereof in the present invention are shown as follows: ##STR1## The microorganisms usable in the above oxidation fermentation include Gluconobacter rubiginosus IFO 3244, Gluconobacter suboxydans IFO 3254, Gluconobacter melanogenus IFO 3293, Pseudomonas fluorescens IFO 3081, Erwinia carotovara IFO 3380 etc.
    Type: Grant
    Filed: November 3, 1992
    Date of Patent: August 2, 1994
    Assignee: Yakurigaku Chuo Kenkyusho
    Inventors: Hidehiko Takahashi, Katsumi Imada, Akira Motoshio
  • Patent number: 4978536
    Abstract: Disclosed is use of a synthetic aluminum silicate as antacid and anti-ulcer preparation, anti-obesity preparation and acne curing preparation. This aluminum silicate is obtained by reacting an aluminum compound and silicic acid or water glass at a weight ratio Al.sub.2 O.sub.3 : SiO.sub.2 of 4.5:1.0-6.0:1.0 in a strongly acidic aqueous solution having an initial pH of 1.0-3.0, then adding thereto a basic substance to reach excess in alkali and then neutralizing the reaction mixture to pH 5.0-7.0 with an acid.
    Type: Grant
    Filed: May 17, 1988
    Date of Patent: December 18, 1990
    Assignee: Yakurigaku Chuo Kenkyusho
    Inventor: Hidehiko Takahashi
  • Patent number: 4847075
    Abstract: An absorbent prepared by supporting an organic or inorganic reductive substance on hydrated aluminum silicate is useful as a pharmaceutical or as an absorbent for precious metal complexes such as gold complex, silver complex and the like.
    Type: Grant
    Filed: June 11, 1982
    Date of Patent: July 11, 1989
    Assignee: Yakurigaku Chuo Kenkyusho
    Inventor: Hidehiko Takahashi
  • Patent number: 4545982
    Abstract: Novel acyl compounds 3-acyloxy-4(H)-pyran-4-ones were obtained by reacting 3-hydroxy-4(H)-pyran-4-one with acyl halides. The acyl compounds and their starting compound exhibit a skin-lightening effect on the skin and are preferably used as an active constituent in skin-lightening cosmetic preparations or local demelanizing agents.
    Type: Grant
    Filed: March 17, 1982
    Date of Patent: October 8, 1985
    Assignee: Yakurigaku Chuo Kenkyusho
    Inventor: Hidehiko Takahashi
  • Patent number: 4361581
    Abstract: 4-Isopropyltropolone having the formula: ##STR1## and/or the fatty acid esters thereof having the formula: ##STR2## (wherein R is a hydrocarbon group having 1 to 18 carbon atoms) have the excellent skin-beautifying and anti-suntan effects and are usable as active ingredients for the skin-beautifying cosmetics. The fatty acid esters of 4-isopropyltropolone are novel substances.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: November 30, 1982
    Assignees: Yasuaki Fukuda, Yakurigaku Chuo Kenkyusho
    Inventor: Yasuaki Fukuda