Patents Assigned to Zedira GmbH
  • Inhibitors of blood coagulation factor XIII
    Patent number: 11472838
    Abstract: The invention relates to a compound of general formula (I) as novel inhibitor of blood coagulation factor XIII, methods for synthesis thereof and to use thereof for the prophylaxis or treatment of diseases associated with blood coagulation factor XIII.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: October 18, 2022
    Assignee: Zedira GmbH
    Inventors: Martin Hils, Ralf Pasternack, Christian Büchold
  • Inhibitors of transglutaminases
    Patent number: 11072634
    Abstract: The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: July 27, 2021
    Assignee: Zedira GmbH
    Inventors: Martin Hils, Ralf Pasternack, Christian Büchold
  • INHIBITORS OF TRANSGLUTAMINASES
    Publication number: 20190322700
    Abstract: The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases.
    Type: Application
    Filed: January 2, 2018
    Publication date: October 24, 2019
    Applicant: Zedira GmbH
    Inventors: Martin Hils, Ralf Pasternack, Christian Büchold
  • Derivatives of pyridinone as inhibitors for tissue transglutaminase
    Patent number: 9434763
    Abstract: The invention relates to pyridinone derivatives of general formula (I) as inhibitors of tissue transglutaminase, to methods for producing the pyridinone derivatives, to pharmaceutical compositions containing said pyridinone derivatives and to their use for the prophylaxis and treatment of diseases associated with tissue transglutaminase.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: September 6, 2016
    Assignee: ZEDIRA GMBH
    Inventors: Christian Buchold, Uwe Gerlach, Martin Hils, Ralf Pasternack, Johannes Weber
  • CRYSTAL STRUCTURE OF BLOOD COAGULATION FACTOR XIIIA
    Publication number: 20160137990
    Abstract: The present invention relates to crystal forms of blood coagulation factor XIIIa, crystal structure information obtained from them, methods of preparing such crystal forms, their use for the identification and/or design of inhibitors of blood coagulation factor XIIIa activity and methods for identifying, optimizing and designing compounds which should have the ability to interact with or inhibit blood coagulation factor XIIIa.
    Type: Application
    Filed: December 10, 2013
    Publication date: May 19, 2016
    Applicant: ZEDIRA GMBH
    Inventors: Martin Hils, Ralf Pasternack, Christian Buchold, Johannes Weber, Andreas Heine, Gerhard Klebe, Martin Stieler
  • Stabilized open form transglutaminase as a diagnostic indictor for autoimmune diseases
    Patent number: 8808980
    Abstract: The present invention relates to the diagnosis of disorders or dysfunctions characterized by autoimmune responses to the enzyme class of transglutaminases. The present invention provides a novel open structure of the transglutaminases in a stabilized form which renders new epitopes accessible for antibody-binding.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: August 19, 2014
    Assignee: Zedira GmbH
    Inventors: Martin Hils, Ralf Pasternack, Johannes Weber
  • Michael systems as transglutaminase inhibitors
    Patent number: 8471063
    Abstract: Described herein are peptide derivatives and peptidomimetics as inhibitors for transglutaminases, methods for their preparation, pharmaceutical compositions containing said compounds as well as uses of said transglutaminase inhibitors in particular for the treatment of coeliac disease and transglutaminase dependent diseases.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: June 25, 2013
    Assignee: Zedira GmbH
    Inventor: Kai Oertel