Patents Assigned to Zeochem AG
  • Patent number: 9925522
    Abstract: A material for reverse phase chromatography comprises surface modifying apolar and charged groups bound to a solid support, said charged groups being present in amounts of about 0.25 to about 22% of the surface modifying groups, or in amounts of about 0.01 ?mol/m2 to 0.8 ?mol/m2 referred to the surface of the solid support for a material with a total amount of surface modifying groups of 3.6 ?mol/m2. Such material and suitable purification conditions for active pharmaceutical ingredients (APIs) like peptides can be evaluated by (a) determining the isoelectric point (pI) of the API of interest, (b) choosing a pH in a range where the solid phase material is stable, (c) determining the difference pI?pH and (d) if the difference pI?pH is positive, choosing an anion exchange (AIEX) material, or if the difference pI?pH is negative, choosing an cation exchange (CIEX) material.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: March 27, 2018
    Assignee: ZEOCHEM AG
    Inventors: Nicola Forrer, Mandy Erdmann, David Gétaz, Massimo Morbidelle, Susanna Bernardi, Rushd Khalaf
  • Publication number: 20150087816
    Abstract: A material for reverse phase chromatography comprises surface modifying apolar and charged groups bound to a solid support, said charged groups being present in amounts of about 0.25 to about 22% of the surface modifying groups, or in amounts of about 0.01 ?mol/m2 to 0.8 ?mol/m2 referred to the surface of the solid support for a material with a total amount of surface modifying groups of 3.6 ?mol/m2. Such material and suitable purification conditions for active pharmaceutical ingredients (APIs) like peptides can be evaluated by (a) determining the isoelectric point (pI) of the API of interest, (b) choosing a pH in a range where the solid phase material is stable, (c) determining the difference pI-pH and (d) if the difference pI-pH is positive, choosing an anion exchange (AIEX) material, or if the difference pI-pH is negative, choosing an cation exchange (CIEX) material.
    Type: Application
    Filed: March 21, 2013
    Publication date: March 26, 2015
    Applicant: ZEOCHEM AG
    Inventors: Nicola Forrer, Mandy Erdmann, David Gétaz, Massimo Morbidelle, Susanna Bernardi, Rushd Khalaf
  • Patent number: 7651550
    Abstract: A desorption process and a process for producing a catalytically deactivated formed zeolitic adsorbent, whereby both processes are suitable to improve the lifetime of a formed zeolitic adsorbent in the removal of sulfur compounds from sulfur contaminated gas and liquid feed streams. The adsorbent is in particular a synthetic 13X or LSX faujasite with a silica to alumina ratio from 1.9:1.0 to about 3.0:1.0. The cations of the faujasite include alkali and alkaline earth metals. The formed zeolite mixture is preferably catalytically deactivated due to a phosphate treatment. The desorption is carried out thermally, wherein the heat treatment is done at different temperature stages to avoid decomposition of the organic sulfur compounds.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: January 26, 2010
    Assignee: Zeochem AG
    Inventors: Peter Hawes, Andreas Scheuble, Beat Kleeb, Armin Pfenninger
  • Publication number: 20070193939
    Abstract: Abstract Described is a desorption process and a process for producing a catalytically deactivated formed zeolitic adsorbent, whereby both processes are suitable to improve the lifetime of a formed zeolithic adsorbant in the removal of sulfur compounds from sulfur contaminated gas and liquid feed streams. The adsorbent is in particular a synthetic 13X or LSX faujasite with a silica to alumina ratio from 1.9:1.0 to about 3.0:1.0. The cations of the faujasite include alkali and alkaline earth metals. The formed zeolite mixture is preferably catalytically deactivated due to a phosphate treatment. The desorption is carried out thermally, wherein the heat treatment is done at different temperature stages to avoid decomposition of the organic sulfur compounds.
    Type: Application
    Filed: June 6, 2003
    Publication date: August 23, 2007
    Applicant: ZEOCHEM AG
    Inventors: Peter Hawes, Andreas Scheuble, Beat Kleeb, Armin Pfenninger
  • Publication number: 20070062369
    Abstract: Disclosed is a synthetic zeolite by means of which gas streams containing steam and carbon dioxide as impurities can be purified. The zeolitic adsorbing agent is a 13X type or LSX type faujasite or a mixture of both types that are deformed with a binder, at least some parts of which are highly dispersed. Said novel adsorption system allows extraordinarily high adsorption capacities to be obtained while keeping the mass transfer zones short resulting in a longer service life of the adsorption systems before carbon dioxide is able to break through.
    Type: Application
    Filed: April 7, 2004
    Publication date: March 22, 2007
    Applicant: ZEOCHEM AG
    Inventors: Armin Pfenninger, Sonja Odolo-Hitz