Abstract: The use of proteins extracted with perchloric acid from animal organs, for the preparation of medicaments active against autoimmune diseases, in particular with activity against atheroscelerosis, arthritis, multiple sclerosis, and diabetes.

Abstract: A new protein obtained through recombinant DNA techniques which can be used in diagnostics and in therapy, in particular for treating tumors, a cDNA molecule encoding such a protein, a process for preparing it, and expression vectors and host cells which may be used in such a process.

Abstract: The use of proteins extracted with perchloric acid from animal organs for the preparation of medicaments active against autoimmune diseases, in particular with activity against atherosclerosis, arthritis, multiple sclerosis, and diabetes.

Abstract: Proteins extractable with perchloric acid from mammal liver, in particular from goat liver, are capable of lowering blood levels of Tumor Necrosis Factor (TNF) and can be used for the treatment of multiple sclerosis, rheumatoid arthritis, septic shock and other pathologies characterized by TNF hyperproduction.

Abstract: The present invention relates to the discovery that a protein, having a molecular weight of about 14 Kd, extracted with perchloric acid from animal organs such as goat liver, has anti-retroviral activity, and may be used in the treatment of Human Immunodeficiency Virus.

Abstract: A complete cDNA sequence (SEQ ID NO: 1) is described, which codes for a 14 kDa protein (SEQ ID NO: 2) obtainable from goat liver. This protein shows marked anti-neoplastic activity both in vitro and in vivo. The serum of animals immunized with this protein displays cytotoxic activity against human tumor cell lines. The cDNA sequence of the invention may be obtained by procedures involving, among other things, the use of degenerate oligonucleotides.

Abstract: Substances of polypeptide nature are obtainable by extraction with HClO.sub.4 and 3M KCl from animal tissue homogenates. The substances have the characteristics of (a) molecular weights ranging from 10,000 to 50,000 daltons (by polyacrylamide gel electrophoresis); (b) are capable of inducing the formation of antibodies which specifically bind in vivo or in vitro antigens which are present in human tumoral cells, when administered to different animal species; (c) are capable of decreasing or inhibiting pain; (d) induce an effect of cell lysis; and (e) inhibit or slow tumor growth, when administered to humans affected by malignant tumors of different kinds.

Abstract: The present invention relates to proteins that may be extracted from mammalian livers. The proteins of the invention have a molecular weight of 14 Kda as measured by SDS-PAGE electrophoresis and comprise the sequence identified in the application as Sequence No. 1. The proteins of the invention may be incorporated in pharmaceutical agents, used as diagnostic tools in oncology and used in the treatment of neoplastic diseases.