Patents Assigned to Zoetis LLC
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Patent number: 11505548Abstract: Provided herein are Heterocyclic compounds of formula I: and pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein W, X, Y, R1, R2, and RN are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.Type: GrantFiled: April 24, 2020Date of Patent: November 22, 2022Assignees: CELGENE CORPORATION, ZOETIS LLCInventors: Natalie Hawryluk, Stacie S. Canan, Kevin R. Condroski, Graham Kyne, Matthew Bedore, Sanjay Menon
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Publication number: 20150190499Abstract: An influenza C virus has been isolated from a bovine species. Influenza C virus polynucleotides and polypeptides have also been identified. Immunogenic compositions are also described, as well as diagnostic kits and methods of detection.Type: ApplicationFiled: July 18, 2013Publication date: July 9, 2015Applicant: Zoetis LLCInventor: Siao-Kun W. Welch
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Publication number: 20150182619Abstract: This invention relates to a method of treating a dog for canine diseases comprising administering to the dog therapeutically effective amounts of a vaccine, wherein the vaccine comprises viral antigens, a bacterin, or both, and wherein the vaccine is administered subcutaneously or orally according to the schedules provided herein.Type: ApplicationFiled: May 20, 2014Publication date: July 2, 2015Applicant: Zoetis LLCInventors: Cassius McAllister Tucker, John David Haworth
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Patent number: 9061013Abstract: This invention recites isoxazoline substituted derivatives of Formula (1) stereoisomers thereof, geometric isomers thereof, veterinarily acceptable salts 5 thereof, compositions thereof, and their use as a parasiticide in animals. The variables A, W, R 1a, R 1b, R 1c, R 2, R 3, R 5, and n are as described herein.Type: GrantFiled: March 8, 2012Date of Patent: June 23, 2015Assignee: Zoetis LLCInventors: Valerie A. Vaillancourt, John A. Wendt, Graham M. Kyne, Sanjay Menon
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Patent number: 9038568Abstract: An advancement system for an in ovo injection apparatus is provided. Such an advancement system is configured to advance an egg carrier carrying a plurality of avian eggs to an injection assembly. The advancement system includes a guide assembly configured to receive the egg carrier and provide support thereto during advancement of the egg carrier. A manual advancement device slidingly engages the guide assembly such that the manual advancement device is movable along the guide assembly. The manual advancement device is capable of interacting with a trailing end of the egg carrier to advance the egg carrier to an injection position. At least one stop is positioned to interact with the manual advancement device during advancement of the egg carrier so as to prevent progression of the manual advancement device beneath the injection assembly, thereby locating the egg carrier at the injection position. An associated method is also provided.Type: GrantFiled: March 15, 2013Date of Patent: May 26, 2015Assignee: Zoetis LLCInventors: Joseph Federowicz, Louis Pallay
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Patent number: 8987283Abstract: Described herein is pyrrolo{2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and methods for the preparation of these compounds.Type: GrantFiled: January 30, 2012Date of Patent: March 24, 2015Assignee: Zoetis LLCInventors: Mark J. Mitton-Fry, Pamela J. Berlinski, Matthew J. Birchmeier, Jerry W. Bowman, Andrea Joy Gonzales, Steven Glenn Kamerling, Donald Wayne Mann
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Patent number: 8987320Abstract: The present invention relates to solid salt forms of the 3-pyrrole substituted 2-indolinone compound 5-[5-fluoro-2-oxo-1, 2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pirrolidin-1-yl-ethyl)-amide. It also relates to polymorphs of the phosphate salt of the amide. The invention further relates to the use of the salts and polymorphs in the treatment of protein kinase related disorders.Type: GrantFiled: February 6, 2012Date of Patent: March 24, 2015Assignee: Zoetis LLCInventors: Changquan C. Sun, Michael Hawley
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Patent number: 8969536Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.Type: GrantFiled: October 16, 2009Date of Patent: March 3, 2015Assignee: Zoetis LLCInventors: Gregory Paul Nitzel, Robert Gerard Ankenbauer, Jay Gregory Calvert, Donna Steuerwald Dunyak, Jacqueline Gayle Marx, Nancee Lois Olen, Douglas Steven Pearce, Mira Ivanova Stoeva, James Richard Thompson
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Patent number: 8962681Abstract: The present invention relates to a method of treating a parasitic infection in an animal, particularly a filarial endoparasitic infection, comprising administering an effective amount of a Formula (I) compound or a Formula (II) compound stereoisomer thereof, or veterinarily acceptable salt of said compound or stereoisomer thereof, or in combination with at least one additional veterinary agent, wherein: R1, R2, R3, R4, R5, R1a, R1b, R1c, R1d, R1e are as described herein.Type: GrantFiled: October 8, 2012Date of Patent: February 24, 2015Assignee: Zoetis LLCInventors: George Anthony Conder, Kevin Evans, Patrick F. M. Meeus, Debra Jean Woods
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Publication number: 20150050305Abstract: Immunogenic compositions directed against Hendra and/or Nipah viruses, and methods of its use, are provided. In addition, methods of distinguishing subjects vaccinated with the immunogenic compositions of the invention from those infected with Hendra and/or Nipah virus are provided.Type: ApplicationFiled: May 14, 2012Publication date: February 19, 2015Applicant: ZOETIS LLCInventors: Martin Elhay, Christopher C. Broder, Jin-an Huang
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Patent number: 8952149Abstract: Described herein are antibacterial compounds of formula I, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical composition.Type: GrantFiled: September 24, 2013Date of Patent: February 10, 2015Assignee: Zoetis LLCInventors: Michael Curtis, Timothy Allan Johnson, Manjinder S. Lall, Peter Laurence Toogood, Joseph S. Warmus
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Patent number: 8921535Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.Type: GrantFiled: April 16, 2010Date of Patent: December 30, 2014Assignee: Zoetis LLCInventors: Gregory Paul Nitzel, Robert Gerard Ankenbauer, Jay Gregory Calvert, Donna Steuerwald Dunyak, Jacqueline Gayle Marx, Nancee Lois Oien, Douglas Steven Pearce, Mira Ivanova Stoeva, James Richard Thompson
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Patent number: 8895025Abstract: The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.Type: GrantFiled: October 29, 2009Date of Patent: November 25, 2014Assignee: Zoetis LLCInventors: Jay Gregory Calvert, Michael G. Sheppard, Siao-Kun W. Welch, Raymond R. R. Rowland, Dal-Young Kim
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Publication number: 20140302488Abstract: The present invention relates to improved diagnostic methods and kits for differentiating between (a) animals administered a chimeric pestivirus, and (b) animals infected with a wild-type bovine viral diarrhea virus (BVDV) or immunized with a conventional BVDV vaccine.Type: ApplicationFiled: August 24, 2011Publication date: October 9, 2014Applicant: Zoetis LLCInventors: Robert G. Ankenbauer, Lynn D. Nelson, Nancee L. Oien, Siao-Kun W. Welch
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Patent number: 8846388Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.Type: GrantFiled: April 16, 2010Date of Patent: September 30, 2014Assignee: Zoetis LLCInventors: Gregory Paul Nitzel, Robert Gerard Ankenbauer, Jay Gregory Calvert, Donna Steuerwald Dunyak, Jacqueline Gayle Marx, Nancee Lois Oien, Douglas Steven Pearce, Mira Ivanova Stoeva, James Richard Thompson
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Publication number: 20140286980Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length TTV genomes that can replicate efficiently in host animals and tissue culture.Type: ApplicationFiled: May 24, 2012Publication date: September 25, 2014Applicant: ZOETIS LLCInventor: Jacqueline Gayle Marx
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Publication number: 20140271695Abstract: The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino acids. The present invention is useful, inter alia, as a prophylactic and/or therapeutic agent for the modification of fertility and behaviour patterns of animals, the achievement of livestock production gains such as increasing growth, decreasing feed conversion ratios or the control of unwanted organoleptic characteristics or the treatment of disorders of the reproductive organs.Type: ApplicationFiled: April 18, 2014Publication date: September 18, 2014Applicant: Zoetis LLCInventor: Michael Kerin McNamara
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Publication number: 20140242569Abstract: Methods for increasing breast muscle weight in poultry are disclosed herein. These methods can include delivery of compositions via in ovo administration. The methods disclosed herein also encompass the delivery of proteins. The methods disclosed herein are effective for increasing breast muscle weight in poultry, both in the embryo, and at slaughter age.Type: ApplicationFiled: February 19, 2014Publication date: August 28, 2014Applicant: Zoetis LLCInventor: Parag Chary
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Publication number: 20140234355Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.Type: ApplicationFiled: December 19, 2013Publication date: August 21, 2014Applicant: Zoetis LLCInventors: Gregory Paul NITZEL, Robert Gerard Ankenbauer, Jay Gregory Calvert, Donna Steuerwald Dunyak, Jacqueline Gayle Marx, Nancee Lois Oien, Douglas Steven Pearce, Mira Ivanova Stoeva, James Richard Thompson
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Patent number: 8790651Abstract: An isolated antibody that specifically binds to at least one of canine Interleukin-31 (IL-31) or feline IL-31 is provided. Such antibodies can be in the form of diagnostic and/or veterinary compositions useful for treating a pruritic and/or allergic condition in dogs or cats.Type: GrantFiled: June 28, 2012Date of Patent: July 29, 2014Assignee: Zoetis LLCInventors: Gary F. Bammert, Steven A. Dunham